The contribution of parental alcohol use disorders and other psychiatric illness to the risk of alcohol use disorders in the offspring

Holger J Sørensen, Ann M Manzardo, Joachim Knop, Elizabeth C Penick, Wendy Madarasz, Elizabeth J Nickel, Ulrik Becker, Erik L Mortensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Few population-based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).

METHODS: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.

RESULTS: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.

CONCLUSIONS: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.

OriginalsprogEngelsk
TidsskriftAlcoholism: Clinical and Experimental Research
Vol/bind35
Udgave nummer7
Sider (fra-til)1315-20
Antal sider6
ISSN0145-6008
DOI
StatusUdgivet - jul. 2011

Fingeraftryk

Alcohols
Alcoholism
Mothers
Psychiatry
Nuclear Family
Odds Ratio
Cohort Studies
Parents
Health

Citer dette

Sørensen, Holger J ; Manzardo, Ann M ; Knop, Joachim ; Penick, Elizabeth C ; Madarasz, Wendy ; Nickel, Elizabeth J ; Becker, Ulrik ; Mortensen, Erik L. / The contribution of parental alcohol use disorders and other psychiatric illness to the risk of alcohol use disorders in the offspring. I: Alcoholism: Clinical and Experimental Research. 2011 ; Bind 35, Nr. 7. s. 1315-20.
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title = "The contribution of parental alcohol use disorders and other psychiatric illness to the risk of alcohol use disorders in the offspring",
abstract = "BACKGROUND: Few population-based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).METHODS: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.RESULTS: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95{\%} CI 1.42 to 2.71 and 1.99; 95{\%} CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95{\%} CI 1.15 to 1.86 and 1.26; 95{\%} CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.CONCLUSIONS: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.",
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note = "Copyright {\circledC} 2011 by the Research Society on Alcoholism.",
year = "2011",
month = "7",
doi = "10.1111/j.1530-0277.2011.01467.x",
language = "English",
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The contribution of parental alcohol use disorders and other psychiatric illness to the risk of alcohol use disorders in the offspring. / Sørensen, Holger J; Manzardo, Ann M; Knop, Joachim; Penick, Elizabeth C; Madarasz, Wendy; Nickel, Elizabeth J; Becker, Ulrik; Mortensen, Erik L.

I: Alcoholism: Clinical and Experimental Research, Bind 35, Nr. 7, 07.2011, s. 1315-20.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The contribution of parental alcohol use disorders and other psychiatric illness to the risk of alcohol use disorders in the offspring

AU - Sørensen, Holger J

AU - Manzardo, Ann M

AU - Knop, Joachim

AU - Penick, Elizabeth C

AU - Madarasz, Wendy

AU - Nickel, Elizabeth J

AU - Becker, Ulrik

AU - Mortensen, Erik L

N1 - Copyright © 2011 by the Research Society on Alcoholism.

PY - 2011/7

Y1 - 2011/7

N2 - BACKGROUND: Few population-based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).METHODS: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.RESULTS: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.CONCLUSIONS: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.

AB - BACKGROUND: Few population-based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).METHODS: Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.RESULTS: Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.CONCLUSIONS: Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.

KW - Alcohol-Related Disorders

KW - Child

KW - Child of Impaired Parents

KW - Cohort Studies

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Mental Disorders

KW - Parents

KW - Prospective Studies

KW - Registries

KW - Risk Factors

KW - Sex Factors

U2 - 10.1111/j.1530-0277.2011.01467.x

DO - 10.1111/j.1530-0277.2011.01467.x

M3 - Journal article

VL - 35

SP - 1315

EP - 1320

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 7

ER -