The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample

Ann-Louise Esserlind, A. F. Christensen, S Steinberg, N. Grarup, O. Pedersen, Torben Hansen, T Werge, T. F. Hansen, L L N Husemoen, A. Linneberg, E. Budtz-Jorgensen, Maria L. Westergaard, Hreinn Stefansson, J. Olesen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits. © 2016 International Headache Society.
OriginalsprogEngelsk
TidsskriftCephalalgia
Vol/bind36
Udgave nummer7
Sider (fra-til)615-623
ISSN0333-1024
DOI
StatusUdgivet - 2016

Citer dette

Esserlind, A-L., Christensen, A. F., Steinberg, S., Grarup, N., Pedersen, O., Hansen, T., ... Olesen, J. (2016). The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample. Cephalalgia, 36(7), 615-623. https://doi.org/10.1177/0333102415570492
Esserlind, Ann-Louise ; Christensen, A. F. ; Steinberg, S ; Grarup, N. ; Pedersen, O. ; Hansen, Torben ; Werge, T ; Hansen, T. F. ; Husemoen, L L N ; Linneberg, A. ; Budtz-Jorgensen, E. ; Westergaard, Maria L. ; Stefansson, Hreinn ; Olesen, J. / The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample. I: Cephalalgia. 2016 ; Bind 36, Nr. 7. s. 615-623.
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title = "The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample",
abstract = "Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits. {\circledC} 2016 International Headache Society.",
author = "Ann-Louise Esserlind and Christensen, {A. F.} and S Steinberg and N. Grarup and O. Pedersen and Torben Hansen and T Werge and Hansen, {T. F.} and Husemoen, {L L N} and A. Linneberg and E. Budtz-Jorgensen and Westergaard, {Maria L.} and Hreinn Stefansson and J. Olesen",
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Esserlind, A-L, Christensen, AF, Steinberg, S, Grarup, N, Pedersen, O, Hansen, T, Werge, T, Hansen, TF, Husemoen, LLN, Linneberg, A, Budtz-Jorgensen, E, Westergaard, ML, Stefansson, H & Olesen, J 2016, 'The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample', Cephalalgia, bind 36, nr. 7, s. 615-623. https://doi.org/10.1177/0333102415570492

The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample. / Esserlind, Ann-Louise; Christensen, A. F.; Steinberg, S; Grarup, N.; Pedersen, O.; Hansen, Torben; Werge, T; Hansen, T. F.; Husemoen, L L N; Linneberg, A.; Budtz-Jorgensen, E.; Westergaard, Maria L.; Stefansson, Hreinn; Olesen, J.

I: Cephalalgia, Bind 36, Nr. 7, 2016, s. 615-623.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample

AU - Esserlind, Ann-Louise

AU - Christensen, A. F.

AU - Steinberg, S

AU - Grarup, N.

AU - Pedersen, O.

AU - Hansen, Torben

AU - Werge, T

AU - Hansen, T. F.

AU - Husemoen, L L N

AU - Linneberg, A.

AU - Budtz-Jorgensen, E.

AU - Westergaard, Maria L.

AU - Stefansson, Hreinn

AU - Olesen, J.

PY - 2016

Y1 - 2016

N2 - Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits. © 2016 International Headache Society.

AB - Introduction The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population. Methods Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model. Results We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks. Conclusion Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits. © 2016 International Headache Society.

U2 - 10.1177/0333102415570492

DO - 10.1177/0333102415570492

M3 - Journal article

C2 - 25667298

VL - 36

SP - 615

EP - 623

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 7

ER -