The Angiotensin AT2 Receptor

From Enigma to Therapeutic Target

Thomas Unger*, Ulrike M. Steckelings, Victor J. Dzau

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Resumé

Since its discovery, 25 years ago, the angiotensin AT<inf>2</inf> receptor (AT<inf>2</inf>R) has puzzled the scientific community because of its distinct -localization, regulation, signaling pathways, and biological effects separating it clearly from the classical features of the renin-angiotensin system (RAS) mediated by the angiotensin AT<inf>1</inf> receptor. Intensive research over the years has revealed major characteristics of the AT<inf>2</inf>R as a modulatory player involved in antiproliferation, anti-inflammation, natriuresis, neuroregeneration, and apoptosis, that is, -biological programs that can counterbalance pathological processes and enable recovery from disease. The AT<inf>2</inf>R has thus mutated from an "-enigmatic" receptor to a significant member of the "protective arm" of the RAS. The recent development of novel, small molecule- and peptide-derived AT<inf>2</inf>R agonists offers a therapeutic potential in humans with a variety of clinical indications.

OriginalsprogEngelsk
TitelThe Protective Arm of the Renin Angiotensin System (RAS) : Functional Aspects and Therapeutic Implications
RedaktørerThomas Unger, Ulrike M. Steckelings, Robson A. Santos
ForlagAcademic Press
Publikationsdato22. apr. 2015
Udgave1.
Sider1-9
Kapitel1
ISBN (Trykt)9780128013649
ISBN (Elektronisk)9780128014851
DOI
StatusUdgivet - 22. apr. 2015

Fingeraftryk

Renin-Angiotensin System
Angiotensin Type 2 Receptor
Angiotensin Type 1 Receptor
Natriuresis
Apoptosis
Peptides
Research

Emneord

  • Angiotensin AT<inf>2</inf> receptor
  • AT<inf>2</inf>R features
  • AT<inf>2</inf>R functions
  • AT<inf>2</inf>R research history
  • Neuroprotection
  • Renin-angiotensin system

Citer dette

Unger, T., Steckelings, U. M., & Dzau, V. J. (2015). The Angiotensin AT2 Receptor: From Enigma to Therapeutic Target. I T. Unger, U. M. Steckelings, & R. A. Santos (red.), The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications (1. udg., s. 1-9). Academic Press. https://doi.org/10.1016/B978-0-12-801364-9.00001-8
Unger, Thomas ; Steckelings, Ulrike M. ; Dzau, Victor J. / The Angiotensin AT2 Receptor : From Enigma to Therapeutic Target. The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. red. / Thomas Unger ; Ulrike M. Steckelings ; Robson A. Santos. 1. udg. Academic Press, 2015. s. 1-9
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Unger, T, Steckelings, UM & Dzau, VJ 2015, The Angiotensin AT2 Receptor: From Enigma to Therapeutic Target. i T Unger, UM Steckelings & RA Santos (red), The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. 1. udg, Academic Press, s. 1-9. https://doi.org/10.1016/B978-0-12-801364-9.00001-8

The Angiotensin AT2 Receptor : From Enigma to Therapeutic Target. / Unger, Thomas; Steckelings, Ulrike M.; Dzau, Victor J.

The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. red. / Thomas Unger; Ulrike M. Steckelings; Robson A. Santos. 1. udg. Academic Press, 2015. s. 1-9.

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

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N2 - Since its discovery, 25 years ago, the angiotensin AT2 receptor (AT2R) has puzzled the scientific community because of its distinct -localization, regulation, signaling pathways, and biological effects separating it clearly from the classical features of the renin-angiotensin system (RAS) mediated by the angiotensin AT1 receptor. Intensive research over the years has revealed major characteristics of the AT2R as a modulatory player involved in antiproliferation, anti-inflammation, natriuresis, neuroregeneration, and apoptosis, that is, -biological programs that can counterbalance pathological processes and enable recovery from disease. The AT2R has thus mutated from an "-enigmatic" receptor to a significant member of the "protective arm" of the RAS. The recent development of novel, small molecule- and peptide-derived AT2R agonists offers a therapeutic potential in humans with a variety of clinical indications.

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Unger T, Steckelings UM, Dzau VJ. The Angiotensin AT2 Receptor: From Enigma to Therapeutic Target. I Unger T, Steckelings UM, Santos RA, red., The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications. 1. udg. Academic Press. 2015. s. 1-9 https://doi.org/10.1016/B978-0-12-801364-9.00001-8