The "adjuvant effect" of the polymorphic B-G antigens of the chicken major histocompatibility complex analyzed using purified molecules incorporated in liposomes.

J Salomonsen, H Eriksson, K Skjødt, T Lundgreen, M Simonsen, J Kaufman

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The polymorphic B-G region of the chicken major histocompatibility complex has previously been shown to mediate an "adjuvant effect" on the humoral response to other erythrocyte alloantigens. We demonstrate here that B-G molecules purified with monoclonal antibodies exert this adjuvant effect on the production of alloantibodies to chicken class I (B-F) molecules, when the two are in the same liposome. The adjuvant effect may in part be mediated by antibodies, since the antibody response to B-G molecules occurs much faster than the response to B-F molecules, and conditions in which antibodies to B-G are present increase the speed of the response to B-F molecules. We also found that the presence of B-G molecules in separate liposomes results in a lack of response to B-F molecules. In the light of this and other data, we consider the possible roles for the polymorphic B-G molecules, particularly for the generation of B cell diversity, in the immune systems of birds and other animals.
Udgivelsesdato: 1991-Mar
OriginalsprogEngelsk
TidsskriftEuropean Journal of Immunology
Vol/bind21
Udgave nummer3
Sider (fra-til)649-58
Antal sider9
ISSN0014-2980
StatusUdgivet - 1. mar. 1991

Citer dette

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title = "The {"}adjuvant effect{"} of the polymorphic B-G antigens of the chicken major histocompatibility complex analyzed using purified molecules incorporated in liposomes.",
abstract = "The polymorphic B-G region of the chicken major histocompatibility complex has previously been shown to mediate an {"}adjuvant effect{"} on the humoral response to other erythrocyte alloantigens. We demonstrate here that B-G molecules purified with monoclonal antibodies exert this adjuvant effect on the production of alloantibodies to chicken class I (B-F) molecules, when the two are in the same liposome. The adjuvant effect may in part be mediated by antibodies, since the antibody response to B-G molecules occurs much faster than the response to B-F molecules, and conditions in which antibodies to B-G are present increase the speed of the response to B-F molecules. We also found that the presence of B-G molecules in separate liposomes results in a lack of response to B-F molecules. In the light of this and other data, we consider the possible roles for the polymorphic B-G molecules, particularly for the generation of B cell diversity, in the immune systems of birds and other animals. Udgivelsesdato: 1991-Mar",
keywords = "Adjuvants, Immunologic, Animals, Antibody Formation, B-Lymphocytes, Chickens, Dose-Response Relationship, Immunologic, Erythrocyte Membrane, Histocompatibility Antigens Class I, Isoantibodies, Isoantigens, Liposomes, Major Histocompatibility Complex, Polymorphism, Genetic",
author = "J Salomonsen and H Eriksson and K Skj{\o}dt and T Lundgreen and M Simonsen and J Kaufman",
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The "adjuvant effect" of the polymorphic B-G antigens of the chicken major histocompatibility complex analyzed using purified molecules incorporated in liposomes. / Salomonsen, J; Eriksson, H; Skjødt, K; Lundgreen, T; Simonsen, M; Kaufman, J.

I: European Journal of Immunology, Bind 21, Nr. 3, 01.03.1991, s. 649-58.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The "adjuvant effect" of the polymorphic B-G antigens of the chicken major histocompatibility complex analyzed using purified molecules incorporated in liposomes.

AU - Salomonsen, J

AU - Eriksson, H

AU - Skjødt, K

AU - Lundgreen, T

AU - Simonsen, M

AU - Kaufman, J

PY - 1991/3/1

Y1 - 1991/3/1

N2 - The polymorphic B-G region of the chicken major histocompatibility complex has previously been shown to mediate an "adjuvant effect" on the humoral response to other erythrocyte alloantigens. We demonstrate here that B-G molecules purified with monoclonal antibodies exert this adjuvant effect on the production of alloantibodies to chicken class I (B-F) molecules, when the two are in the same liposome. The adjuvant effect may in part be mediated by antibodies, since the antibody response to B-G molecules occurs much faster than the response to B-F molecules, and conditions in which antibodies to B-G are present increase the speed of the response to B-F molecules. We also found that the presence of B-G molecules in separate liposomes results in a lack of response to B-F molecules. In the light of this and other data, we consider the possible roles for the polymorphic B-G molecules, particularly for the generation of B cell diversity, in the immune systems of birds and other animals. Udgivelsesdato: 1991-Mar

AB - The polymorphic B-G region of the chicken major histocompatibility complex has previously been shown to mediate an "adjuvant effect" on the humoral response to other erythrocyte alloantigens. We demonstrate here that B-G molecules purified with monoclonal antibodies exert this adjuvant effect on the production of alloantibodies to chicken class I (B-F) molecules, when the two are in the same liposome. The adjuvant effect may in part be mediated by antibodies, since the antibody response to B-G molecules occurs much faster than the response to B-F molecules, and conditions in which antibodies to B-G are present increase the speed of the response to B-F molecules. We also found that the presence of B-G molecules in separate liposomes results in a lack of response to B-F molecules. In the light of this and other data, we consider the possible roles for the polymorphic B-G molecules, particularly for the generation of B cell diversity, in the immune systems of birds and other animals. Udgivelsesdato: 1991-Mar

KW - Adjuvants, Immunologic

KW - Animals

KW - Antibody Formation

KW - B-Lymphocytes

KW - Chickens

KW - Dose-Response Relationship, Immunologic

KW - Erythrocyte Membrane

KW - Histocompatibility Antigens Class I

KW - Isoantibodies

KW - Isoantigens

KW - Liposomes

KW - Major Histocompatibility Complex

KW - Polymorphism, Genetic

M3 - Journal article

VL - 21

SP - 649

EP - 658

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 3

ER -