The 5'-3' Distance of RNA Secondary Structures

Hillary S W Han, Christian Reidys

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Abstract Recently, Yoffe and colleagues observed that the average distances between 5'-3' ends of RNA molecules are very small and largely independent of sequence length. This observation is based on numerical computations as well as theoretical arguments maximizing certain entropy functionals. In this article, we compute the exact distribution of 5'-3' distances of RNA secondary structures for any finite n. Furthermore, we compute the limit distribution and show that for n = 30 the exact distribution and the limit distribution are very close. Our results show that the distances of random RNA secondary structures are distinctively lower than those of minimum free energy structures of random RNA sequences.
OriginalsprogEngelsk
TidsskriftJournal of Computational Biology
Vol/bind19
Udgave nummer7
Sider (fra-til)867-878
ISSN1066-5277
DOI
StatusUdgivet - 2012

Fingeraftryk

RNA Secondary Structure
Exact Distribution
Limit Distribution
RNA
Average Distance
Numerical Computation
Free Energy
Entropy
Molecules
Free energy
Observation

Citer dette

Han, Hillary S W ; Reidys, Christian. / The 5'-3' Distance of RNA Secondary Structures. I: Journal of Computational Biology. 2012 ; Bind 19, Nr. 7. s. 867-878.
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The 5'-3' Distance of RNA Secondary Structures. / Han, Hillary S W; Reidys, Christian.

I: Journal of Computational Biology, Bind 19, Nr. 7, 2012, s. 867-878.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Reidys, Christian

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