@article{43103240cf0311deb0fe000ea68e967b,
title = "Th1 and Th2 help for B cells: Differential capacity for induction of autonomous responsiveness to IL-2",
abstract = "Sustained interaction with Th1 cells has been shown to induce IL-2 responsiveness by murine B cells. This is equivalently dependent on CD40, CD54/ICAM-1 and MHC II ligation, and co-cross-linking of CD54 and MHC II in the presence of IL-5 up-regulates a functional IL-2R on B cells. We now show that IL-5 (125 U/ml) synergizes with Th1 cells to induce B cell responses to IL-2, that are maintained following T-cell removal, e.g. autonomous. Th1 help in the absence of IL-5 resulted in weak or undetectable responses following T cell removal. The mechanism of IL-5 synergy involved persistence of IL-2R beta expression following T cell removal, as opposed to enhancement of IL-2R induction or function. The level of contact-induced IL-2R expression on B cells was not itself modified by IL-5. The effects of IL-5 did not overcome the requirement for T contact signals and treatment of B cells with soluble anti-Ig did not circumvent the need for IL-5 for autonomous IL-2 responses. Consistent with the above, interaction with an IL-5-producing Th2 clone induced strong autonomous B cell responses to IL-2. Qualitative differences of Th2 help over that of Th1 may thus be attributable to their differential ability to induce autonomous B cell responsiveness to cytokines. This may be representative of events in which maintenance of cell cycle is important, as is the case in germinal centers.",
keywords = "Animals, B-Lymphocytes, Cells, Cultured, Drug Synergism, Female, Interleukin-2, Interleukin-5, Lymph Nodes, Lymphocyte Activation, Lymphocyte Cooperation, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Antigen, B-Cell, Receptors, Interleukin-2, Th1 Cells, Th2 Cells",
author = "J Poudrier and T Owens",
year = "1995",
month = jun,
day = "1",
language = "English",
volume = "7",
pages = "1021--7",
journal = "International Immunology",
issn = "1460-2377",
publisher = "Oxford University Press",
number = "6",
}