Resumé

Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism. In pregnancy, testosterone levels may be higher in women with PCOS compared with controls. Aims: To compare total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) levels in third-Trimester pregnant women with PCOS and controls and to establish reference ranges for TT, FT, and SHBG in PCOS and controls. Methods: The study was part of the prospective study, Odense Child Cohort. PCOS was diagnosed by questionnaires and/or patient records. Fasting blood samples were collected at gestational week 28 and plasma TT was measured by liquid chromatography-Tandem mass spectrometry in women with PCOS (n = 145) and in women without PCOS (controls, n = 1341). Results: Levels of TT (mean, 2.4 vs 2.0 nmol/L) and FT (mean, 0.005 vs 0.004 nmol/L) were higher, whereas SHBG levels (mean, 447 vs 477 nmol/L)were lower inwomenwith PCOS vs controls (all P,0.001). Reference intervals for TT, FT, and SHBG in women with PCOS and controls were overlapping, and partitioning of reference intervals was an ambiguous decision. In multiple regression analyses, TT and FT levels were positively associated with PCOS status and BMI and inversely associated with age and parity. Offspring sex did not predict maternal TT and FT. Conclusions: TT and FT levels were higher in third-Trimester pregnant women with PCOS compared with controls. Separate reference interval for FT in women with PCOS should be considered.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind103
Udgave nummer10
Sider (fra-til)3819–3827
ISSN0021-972X
DOI
StatusUdgivet - 1. okt. 2018

Fingeraftryk

Polycystic Ovary Syndrome
Third Pregnancy Trimester
Testosterone
Sex Hormone-Binding Globulin
Pregnant Women
Hyperandrogenism
Liquid chromatography
Tandem Mass Spectrometry
Parity

Citer dette

@article{fa5b713f82934b06a92b8a64ae5eb767,
title = "Testosterone levels in third trimester in polycystic ovary syndrome: Odense Child Cohort",
abstract = "Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism. In pregnancy, testosterone levels may be higher in women with PCOS compared with controls. Aims: To compare total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) levels in third-Trimester pregnant women with PCOS and controls and to establish reference ranges for TT, FT, and SHBG in PCOS and controls. Methods: The study was part of the prospective study, Odense Child Cohort. PCOS was diagnosed by questionnaires and/or patient records. Fasting blood samples were collected at gestational week 28 and plasma TT was measured by liquid chromatography-Tandem mass spectrometry in women with PCOS (n = 145) and in women without PCOS (controls, n = 1341). Results: Levels of TT (mean, 2.4 vs 2.0 nmol/L) and FT (mean, 0.005 vs 0.004 nmol/L) were higher, whereas SHBG levels (mean, 447 vs 477 nmol/L)were lower inwomenwith PCOS vs controls (all P,0.001). Reference intervals for TT, FT, and SHBG in women with PCOS and controls were overlapping, and partitioning of reference intervals was an ambiguous decision. In multiple regression analyses, TT and FT levels were positively associated with PCOS status and BMI and inversely associated with age and parity. Offspring sex did not predict maternal TT and FT. Conclusions: TT and FT levels were higher in third-Trimester pregnant women with PCOS compared with controls. Separate reference interval for FT in women with PCOS should be considered.",
keywords = "Adult, Androgens/blood, Biomarkers/blood, Blood Chemical Analysis/standards, Case-Control Studies, Child, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Polycystic Ovary Syndrome/blood, Pregnancy, Pregnancy Trimester, Third, Prognosis, Reference Values, Sex Hormone-Binding Globulin/analysis, Testosterone/blood",
author = "Dorte Glintborg and Jensen, {Richard Christian} and Kristian Bentsen and Schmedes, {Anne V} and Ivan Brandslund and Kyhl, {Henriette Boye} and Niels Bilenberg and Andersen, {Marianne Skovsager}",
year = "2018",
month = "10",
day = "1",
doi = "10.1210/jc.2018-00889",
language = "English",
volume = "103",
pages = "3819–3827",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Heinemann",
number = "10",

}

Testosterone levels in third trimester in polycystic ovary syndrome : Odense Child Cohort. / Glintborg, Dorte; Jensen, Richard Christian; Bentsen, Kristian; Schmedes, Anne V; Brandslund, Ivan; Kyhl, Henriette Boye; Bilenberg, Niels; Andersen, Marianne Skovsager.

I: The Journal of clinical endocrinology and metabolism, Bind 103, Nr. 10, 01.10.2018, s. 3819–3827.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Testosterone levels in third trimester in polycystic ovary syndrome

T2 - Odense Child Cohort

AU - Glintborg, Dorte

AU - Jensen, Richard Christian

AU - Bentsen, Kristian

AU - Schmedes, Anne V

AU - Brandslund, Ivan

AU - Kyhl, Henriette Boye

AU - Bilenberg, Niels

AU - Andersen, Marianne Skovsager

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism. In pregnancy, testosterone levels may be higher in women with PCOS compared with controls. Aims: To compare total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) levels in third-Trimester pregnant women with PCOS and controls and to establish reference ranges for TT, FT, and SHBG in PCOS and controls. Methods: The study was part of the prospective study, Odense Child Cohort. PCOS was diagnosed by questionnaires and/or patient records. Fasting blood samples were collected at gestational week 28 and plasma TT was measured by liquid chromatography-Tandem mass spectrometry in women with PCOS (n = 145) and in women without PCOS (controls, n = 1341). Results: Levels of TT (mean, 2.4 vs 2.0 nmol/L) and FT (mean, 0.005 vs 0.004 nmol/L) were higher, whereas SHBG levels (mean, 447 vs 477 nmol/L)were lower inwomenwith PCOS vs controls (all P,0.001). Reference intervals for TT, FT, and SHBG in women with PCOS and controls were overlapping, and partitioning of reference intervals was an ambiguous decision. In multiple regression analyses, TT and FT levels were positively associated with PCOS status and BMI and inversely associated with age and parity. Offspring sex did not predict maternal TT and FT. Conclusions: TT and FT levels were higher in third-Trimester pregnant women with PCOS compared with controls. Separate reference interval for FT in women with PCOS should be considered.

AB - Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism. In pregnancy, testosterone levels may be higher in women with PCOS compared with controls. Aims: To compare total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) levels in third-Trimester pregnant women with PCOS and controls and to establish reference ranges for TT, FT, and SHBG in PCOS and controls. Methods: The study was part of the prospective study, Odense Child Cohort. PCOS was diagnosed by questionnaires and/or patient records. Fasting blood samples were collected at gestational week 28 and plasma TT was measured by liquid chromatography-Tandem mass spectrometry in women with PCOS (n = 145) and in women without PCOS (controls, n = 1341). Results: Levels of TT (mean, 2.4 vs 2.0 nmol/L) and FT (mean, 0.005 vs 0.004 nmol/L) were higher, whereas SHBG levels (mean, 447 vs 477 nmol/L)were lower inwomenwith PCOS vs controls (all P,0.001). Reference intervals for TT, FT, and SHBG in women with PCOS and controls were overlapping, and partitioning of reference intervals was an ambiguous decision. In multiple regression analyses, TT and FT levels were positively associated with PCOS status and BMI and inversely associated with age and parity. Offspring sex did not predict maternal TT and FT. Conclusions: TT and FT levels were higher in third-Trimester pregnant women with PCOS compared with controls. Separate reference interval for FT in women with PCOS should be considered.

KW - Adult

KW - Androgens/blood

KW - Biomarkers/blood

KW - Blood Chemical Analysis/standards

KW - Case-Control Studies

KW - Child

KW - Cohort Studies

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Polycystic Ovary Syndrome/blood

KW - Pregnancy

KW - Pregnancy Trimester, Third

KW - Prognosis

KW - Reference Values

KW - Sex Hormone-Binding Globulin/analysis

KW - Testosterone/blood

U2 - 10.1210/jc.2018-00889

DO - 10.1210/jc.2018-00889

M3 - Journal article

VL - 103

SP - 3819

EP - 3827

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -