Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations

N E Skakkebaek, Ewa Rajpert-De Meyts, N Jørgensen, Katharina Maria Main, Henrik Leffers, A-M Andersson, A Juul, Tina Kold Jensen, J Toppari

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias/disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that trends in TGCC rates of a population may be 'whistle blowers' of other reproductive health problems. As cancer registries are often of excellent quality - in contrast to registries for congenital abnormalities - health authorities should consider an increase in TGCC as a warning that other reproductive health problems may also be rising.
OriginalsprogEngelsk
TidsskriftInternational Journal of Andrology
Vol/bind30
Udgave nummer4
Sider (fra-til)198-204; discussion 204-5
ISSN0105-6263
DOI
StatusUdgivet - 2007

Fingeraftryk

Whistleblowing
Germ Cell and Embryonal Neoplasms
Population
Hypospadias
Cryptorchidism
Reproductive Health
Registries
Scandinavian and Nordic Countries
Disorders of Sex Development
Male Infertility
Research

Citer dette

Skakkebaek, N. E., Rajpert-De Meyts, E., Jørgensen, N., Main, K. M., Leffers, H., Andersson, A-M., ... Toppari, J. (2007). Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. International Journal of Andrology, 30(4), 198-204; discussion 204-5. https://doi.org/10.1111/j.1365-2605.2007.00776.x
Skakkebaek, N E ; Rajpert-De Meyts, Ewa ; Jørgensen, N ; Main, Katharina Maria ; Leffers, Henrik ; Andersson, A-M ; Juul, A ; Jensen, Tina Kold ; Toppari, J. / Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. I: International Journal of Andrology. 2007 ; Bind 30, Nr. 4. s. 198-204; discussion 204-5.
@article{8ba776f3d81c425daa313c6a26641b5f,
title = "Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations",
abstract = "Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias/disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that trends in TGCC rates of a population may be 'whistle blowers' of other reproductive health problems. As cancer registries are often of excellent quality - in contrast to registries for congenital abnormalities - health authorities should consider an increase in TGCC as a warning that other reproductive health problems may also be rising.",
keywords = "Chromosomes, Human, X, Chromosomes, Human, Y, Fetal Development, Humans, Infertility, Male, Karyotyping, Male, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Testis, World Health",
author = "Skakkebaek, {N E} and {Rajpert-De Meyts}, Ewa and N J{\o}rgensen and Main, {Katharina Maria} and Henrik Leffers and A-M Andersson and A Juul and Jensen, {Tina Kold} and J Toppari",
year = "2007",
doi = "10.1111/j.1365-2605.2007.00776.x",
language = "English",
volume = "30",
pages = "198--204; discussion 204--5",
journal = "International Journal of Andrology",
issn = "0105-6263",
publisher = "Wiley-Blackwell",
number = "4",

}

Skakkebaek, NE, Rajpert-De Meyts, E, Jørgensen, N, Main, KM, Leffers, H, Andersson, A-M, Juul, A, Jensen, TK & Toppari, J 2007, 'Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations', International Journal of Andrology, bind 30, nr. 4, s. 198-204; discussion 204-5. https://doi.org/10.1111/j.1365-2605.2007.00776.x

Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. / Skakkebaek, N E; Rajpert-De Meyts, Ewa; Jørgensen, N; Main, Katharina Maria; Leffers, Henrik; Andersson, A-M; Juul, A; Jensen, Tina Kold; Toppari, J.

I: International Journal of Andrology, Bind 30, Nr. 4, 2007, s. 198-204; discussion 204-5.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations

AU - Skakkebaek, N E

AU - Rajpert-De Meyts, Ewa

AU - Jørgensen, N

AU - Main, Katharina Maria

AU - Leffers, Henrik

AU - Andersson, A-M

AU - Juul, A

AU - Jensen, Tina Kold

AU - Toppari, J

PY - 2007

Y1 - 2007

N2 - Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias/disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that trends in TGCC rates of a population may be 'whistle blowers' of other reproductive health problems. As cancer registries are often of excellent quality - in contrast to registries for congenital abnormalities - health authorities should consider an increase in TGCC as a warning that other reproductive health problems may also be rising.

AB - Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias/disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that trends in TGCC rates of a population may be 'whistle blowers' of other reproductive health problems. As cancer registries are often of excellent quality - in contrast to registries for congenital abnormalities - health authorities should consider an increase in TGCC as a warning that other reproductive health problems may also be rising.

KW - Chromosomes, Human, X

KW - Chromosomes, Human, Y

KW - Fetal Development

KW - Humans

KW - Infertility, Male

KW - Karyotyping

KW - Male

KW - Neoplasms, Germ Cell and Embryonal

KW - Testicular Neoplasms

KW - Testis

KW - World Health

U2 - 10.1111/j.1365-2605.2007.00776.x

DO - 10.1111/j.1365-2605.2007.00776.x

M3 - Journal article

VL - 30

SP - 198-204; discussion 204-5

JO - International Journal of Andrology

JF - International Journal of Andrology

SN - 0105-6263

IS - 4

ER -

Skakkebaek NE, Rajpert-De Meyts E, Jørgensen N, Main KM, Leffers H, Andersson A-M et al. Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. International Journal of Andrology. 2007;30(4):198-204; discussion 204-5. https://doi.org/10.1111/j.1365-2605.2007.00776.x