Ten-year stability and variability, drinking patterns, and impairment in community youth with diagnostic orphan status of alcohol dependence

Maike Grabitz, Silke Behrendt*, Jens Klotsche, Gerhard Buehringer, Roselind Lieb, Hans Ullrich Wittchen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: Some adolescents and young adults who do not fulfill criteria for DSM-IV alcohol abuse (AA) report symptoms of DSM-IV alcohol dependence (AD) below the diagnostic threshold (diagnostic orphans, DOs; 1 or 2 symptoms). Contemporarily, little is known on the long-term stability, risk of progression to AD, impairment, and drinking patterns possibly associated with this status in the first decades of life. Aim: (1) To identify prevalence rates of the DO status from adolescence to early adulthood. To investigate (2) stability and variability of the DO status over time and (3) associations between DO status, drinking patterns and impairment in comparison to subjects with AA, with AD, or without any symptoms. Method: N = 2039 community subjects (aged 14-24. years at baseline) were assessed at baseline and at about four and ten years after baseline. DSM-IV AUD diagnoses were obtained with the DIA-X/M-CIDI. Results: About 11-12% of the sample was classified as DOs at all waves. Over a period of ten years, 18% of DOs were stable in their diagnosis and additional 10% progressed to AD. DOs were comparable to subjects with AA in drinking patterns, impairment and stability of diagnostic status. DOs progressed to AD significantly more often than AA. AD was associated with highest levels in all outcomes of interest. Conclusions: The DO status in adolescence and early adulthood is associated with considerable stability, risk of progression and problematic alcohol intake. In consequence, it can be meaningful for the timely identification of early stages of clinically relevant alcohol problems. For subjects with DO status early specific interventions are required.

OriginalsprogEngelsk
TidsskriftAddictive Behaviors
Vol/bind37
Udgave nummer4
Sider (fra-til)399-406
Antal sider8
ISSN0306-4603
DOI
StatusUdgivet - 1. apr. 2012

Fingeraftryk

Alcoholism
Drinking
Alcohols
Diagnostic and Statistical Manual of Mental Disorders
Alcohol Drinking
Young Adult

Citer dette

Grabitz, Maike ; Behrendt, Silke ; Klotsche, Jens ; Buehringer, Gerhard ; Lieb, Roselind ; Wittchen, Hans Ullrich. / Ten-year stability and variability, drinking patterns, and impairment in community youth with diagnostic orphan status of alcohol dependence. I: Addictive Behaviors. 2012 ; Bind 37, Nr. 4. s. 399-406.
@article{76baff6370c443f7b6aeccb2364d1fcf,
title = "Ten-year stability and variability, drinking patterns, and impairment in community youth with diagnostic orphan status of alcohol dependence",
abstract = "Objective: Some adolescents and young adults who do not fulfill criteria for DSM-IV alcohol abuse (AA) report symptoms of DSM-IV alcohol dependence (AD) below the diagnostic threshold (diagnostic orphans, DOs; 1 or 2 symptoms). Contemporarily, little is known on the long-term stability, risk of progression to AD, impairment, and drinking patterns possibly associated with this status in the first decades of life. Aim: (1) To identify prevalence rates of the DO status from adolescence to early adulthood. To investigate (2) stability and variability of the DO status over time and (3) associations between DO status, drinking patterns and impairment in comparison to subjects with AA, with AD, or without any symptoms. Method: N = 2039 community subjects (aged 14-24. years at baseline) were assessed at baseline and at about four and ten years after baseline. DSM-IV AUD diagnoses were obtained with the DIA-X/M-CIDI. Results: About 11-12{\%} of the sample was classified as DOs at all waves. Over a period of ten years, 18{\%} of DOs were stable in their diagnosis and additional 10{\%} progressed to AD. DOs were comparable to subjects with AA in drinking patterns, impairment and stability of diagnostic status. DOs progressed to AD significantly more often than AA. AD was associated with highest levels in all outcomes of interest. Conclusions: The DO status in adolescence and early adulthood is associated with considerable stability, risk of progression and problematic alcohol intake. In consequence, it can be meaningful for the timely identification of early stages of clinically relevant alcohol problems. For subjects with DO status early specific interventions are required.",
keywords = "Adolescents, Alcohol dependence, Diagnostic categories, Diagnostic orphans, Drinking",
author = "Maike Grabitz and Silke Behrendt and Jens Klotsche and Gerhard Buehringer and Roselind Lieb and Wittchen, {Hans Ullrich}",
year = "2012",
month = "4",
day = "1",
doi = "10.1016/j.addbeh.2011.11.031",
language = "English",
volume = "37",
pages = "399--406",
journal = "Addictive Behaviors",
issn = "0306-4603",
publisher = "Pergamon Press",
number = "4",

}

Ten-year stability and variability, drinking patterns, and impairment in community youth with diagnostic orphan status of alcohol dependence. / Grabitz, Maike; Behrendt, Silke; Klotsche, Jens; Buehringer, Gerhard; Lieb, Roselind; Wittchen, Hans Ullrich.

I: Addictive Behaviors, Bind 37, Nr. 4, 01.04.2012, s. 399-406.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Ten-year stability and variability, drinking patterns, and impairment in community youth with diagnostic orphan status of alcohol dependence

AU - Grabitz, Maike

AU - Behrendt, Silke

AU - Klotsche, Jens

AU - Buehringer, Gerhard

AU - Lieb, Roselind

AU - Wittchen, Hans Ullrich

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: Some adolescents and young adults who do not fulfill criteria for DSM-IV alcohol abuse (AA) report symptoms of DSM-IV alcohol dependence (AD) below the diagnostic threshold (diagnostic orphans, DOs; 1 or 2 symptoms). Contemporarily, little is known on the long-term stability, risk of progression to AD, impairment, and drinking patterns possibly associated with this status in the first decades of life. Aim: (1) To identify prevalence rates of the DO status from adolescence to early adulthood. To investigate (2) stability and variability of the DO status over time and (3) associations between DO status, drinking patterns and impairment in comparison to subjects with AA, with AD, or without any symptoms. Method: N = 2039 community subjects (aged 14-24. years at baseline) were assessed at baseline and at about four and ten years after baseline. DSM-IV AUD diagnoses were obtained with the DIA-X/M-CIDI. Results: About 11-12% of the sample was classified as DOs at all waves. Over a period of ten years, 18% of DOs were stable in their diagnosis and additional 10% progressed to AD. DOs were comparable to subjects with AA in drinking patterns, impairment and stability of diagnostic status. DOs progressed to AD significantly more often than AA. AD was associated with highest levels in all outcomes of interest. Conclusions: The DO status in adolescence and early adulthood is associated with considerable stability, risk of progression and problematic alcohol intake. In consequence, it can be meaningful for the timely identification of early stages of clinically relevant alcohol problems. For subjects with DO status early specific interventions are required.

AB - Objective: Some adolescents and young adults who do not fulfill criteria for DSM-IV alcohol abuse (AA) report symptoms of DSM-IV alcohol dependence (AD) below the diagnostic threshold (diagnostic orphans, DOs; 1 or 2 symptoms). Contemporarily, little is known on the long-term stability, risk of progression to AD, impairment, and drinking patterns possibly associated with this status in the first decades of life. Aim: (1) To identify prevalence rates of the DO status from adolescence to early adulthood. To investigate (2) stability and variability of the DO status over time and (3) associations between DO status, drinking patterns and impairment in comparison to subjects with AA, with AD, or without any symptoms. Method: N = 2039 community subjects (aged 14-24. years at baseline) were assessed at baseline and at about four and ten years after baseline. DSM-IV AUD diagnoses were obtained with the DIA-X/M-CIDI. Results: About 11-12% of the sample was classified as DOs at all waves. Over a period of ten years, 18% of DOs were stable in their diagnosis and additional 10% progressed to AD. DOs were comparable to subjects with AA in drinking patterns, impairment and stability of diagnostic status. DOs progressed to AD significantly more often than AA. AD was associated with highest levels in all outcomes of interest. Conclusions: The DO status in adolescence and early adulthood is associated with considerable stability, risk of progression and problematic alcohol intake. In consequence, it can be meaningful for the timely identification of early stages of clinically relevant alcohol problems. For subjects with DO status early specific interventions are required.

KW - Adolescents

KW - Alcohol dependence

KW - Diagnostic categories

KW - Diagnostic orphans

KW - Drinking

UR - http://www.scopus.com/inward/record.url?scp=84857062902&partnerID=8YFLogxK

U2 - 10.1016/j.addbeh.2011.11.031

DO - 10.1016/j.addbeh.2011.11.031

M3 - Journal article

C2 - 22233883

AN - SCOPUS:84857062902

VL - 37

SP - 399

EP - 406

JO - Addictive Behaviors

JF - Addictive Behaviors

SN - 0306-4603

IS - 4

ER -