Ten-year clinical outcome of patients treated with a drugeluting stent in the proximal left anterior descending artery segment compared with patients stented in other non-left main coronary segments

Lars Kjøller-Hansen*, Niels Bligaard, Henning Kelbæk, Evald H. Christiansen, Leif Thuesen, Peter R. Hansen, Thomas Engstrøm, Anders Junker, Ulrik Abildgaard, Jens F. Lassen, Jan S. Jensen, Jørgen L. Jeppesen, Anders M. Galløe

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Abstrakt

Aims: The aim of the study was to determine whether patients treated with drug-eluting stents in the proximal left anterior descending artery (LAD) carried a different long-term prognosis from patients treated in other coronary artery segments. Methods and results: Ten-year clinical outcome expressed as all-cause mortality and major adverse cardiac events (MACE: Cardiac death, acute myocardial infarction, or target vessel revascularisation) was determined for 1,479 patients with a single non-left main coronary stenosis treated with a first-generation drug-eluting stent in the SORT OUT II trial. The outcome of patients treated with stents in the proximal LAD (n=365) was compared with that of patients treated in a non-proximal LAD segment (n=1,114). Follow-up was 99.3% complete. All-cause mortality was 24.9% in the proximal LAD group vs. 26.3% in the non-proximal LAD group (p=0.60). MACE occurred less frequently in the proximal LAD group, 24.6% vs. 31.0% with a hazard ratio of 0.77 (95% confidence interval [CI]: 0.61-0.97, p=0.024). After multivariate analysis which included baseline characteristics that were unevenly distributed between the groups, the hazard ratio for MACE was 0.82 (95% CI: 0.65-1.03, p=0.09). Conclusions: Patients treated with a drug-eluting stent in the proximal LAD have similar, if not better, long-term clinical outcome compared with patients stented in other coronary artery segments.

OriginalsprogEngelsk
TidsskriftEuroIntervention
Vol/bind14
Udgave nummer7
Sider (fra-til)764-771
ISSN1774-024X
DOI
StatusUdgivet - 20. sep. 2018

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