@article{7195c9d48408462e92260ad5fdddb15c,
title = "Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition",
abstract = "In this study, we investigated the efficacy of an LNA (locked nucleic acid)-modified DNA aptamer named RNV66 targeting VEGF against various breast cancer cell lines. Our results demonstrate that RNV66 efficiently inhibits breast cancer cell proliferation both in vitro and in vivo. Introduction of LNA nucleotides were crucial for higher efficacy. Furthermore, the binding interaction of RNV66 with VEGF was investigated using molecular dynamic simulations leading to the first computational model of the LNA aptamer–VEGF complex blocking its interaction with VEGF-receptor.",
keywords = "Animals, Antineoplastic Agents/chemistry, Aptamers, Nucleotide/chemistry, Breast Neoplasms/drug therapy, Cell Line, Tumor, Cell Movement/drug effects, Cell Proliferation/drug effects, Female, Guanine, Human Umbilical Vein Endothelial Cells/drug effects, Humans, Mice, Nude, Molecular Docking Simulation, Molecular Dynamics Simulation, Oligonucleotides/chemistry, Tumor Burden/drug effects, Vascular Endothelial Growth Factor A/metabolism",
author = "Edwards, {Stacey L} and Vasanthanathan Poongavanam and {R Kanwar}, Jagat and Kislay Roy and {M. Hillman}, Kristine and Neerati Prasad and Rikke Leth-Larsen and Michael Petersen and Maja Marusic and Janez Plavec and Jesper Wengel and Veedu, {Rakesh N.}",
year = "2015",
month = may,
day = "7",
doi = "10.1039/c5cc02756j",
language = "English",
volume = "51",
pages = "9499--9502",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "46",
}