Targeting EMT in Cancer with Repurposed Metabolic Inhibitors

Vignesh Ramesh, Thomas Brabletz, Paolo Ceppi*

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Abstrakt

Epithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer, metastasis formation and chemoresistance, and therefore represents an attractive target in oncology. However, direct targeting of EMT effector molecules is, in most cases, pharmacologically challenging. Since emerging research has highlighted the distinct metabolic circuits involved in EMT, we propose the use of metabolism-specific inhibitors, FDA approved or under clinical trials, as a drug repurposing approach to target EMT in cancer. Metabolism-inhibiting drugs could be coupled with standard chemo- or immunotherapy to combat EMT-driven resistant and aggressive cancers.

OriginalsprogEngelsk
TidsskriftTrends in Cancer
ISSN2405-8033
DOI
StatusE-pub ahead of print - 15. jul. 2020

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