Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides

Yogesh Yadav, Deepti Sharma, Kumar Kaushik, Vineet Kumar, Amitabh Jha, Ashok K. Prasad, Christophe Len*, Sanjay V. Malhotra, Jesper Wengel, Virinder S. Parmar

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Abstrakt

The synthesis of novel pyrazolylnucleosides 3a–e, 4a–e, 5a–e, and 6a–e are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5a–e and 6a–e were screened for anticancer activities on sixty human tumor cell lines. The compound 6e showed good activity against 39 cancer cell lines. In particular, it showed significant inhibition against the lung cancer cell line Hop-92 (GI50 9.3 µM) and breast cancer cell line HS 578T (GI50 3.0 µM).

OriginalsprogEngelsk
Artikelnummer3922
TidsskriftMolecules
Vol/bind24
Udgave nummer21
Antal sider16
ISSN1420-3049
DOI
StatusUdgivet - 30. okt. 2019

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