Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

Henrik M. Pfundheller; Pia N. Jørgensen; Ulrik S. Sørensen; Sunil K. Sharma; Marie Grimstrup; Claudia Ströch; Poul Nielsen; Garimella Viswanadham; Carl Erik Olsen; Jesper Wengel

doi:10.1039/A708801I

Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

Henrik M. Pfundheller, Pia N. Jørgensen, Ulrik S. Sørensen, Sunil K. Sharma, Marie Grimstrup, Claudia Ströch, Poul Nielsen, Garimella Viswanadham, Carl Erik Olsen, Jesper Wengel

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The methyl glycoside derivatives 4, 6, 10 and 32 have been used as precursors for the synthesis of novel 3′-C-alkyl-modified α- and β-2′-deoxynucleosides. Using an alternative linear strategy, 3′-C-methyl- and 3′-C-azidomethyl-modified thymidines 16 and 17 have been synthesized. Hybridization experiments with oligodeoxynucleotides containing 3′-C-(3-hydroxypropyl)thymidine monomers are reported.

Originalsprog	Engelsk
Tidsskrift	Journal of the Chemical Society, Perkin Transactions 1
Vol/bind	1998
Udgave nummer	8
Sider (fra-til)	1409-1422
ISSN	1472-7781
DOI	https://doi.org/10.1039/A708801I
Status	Udgivet - 1998

Dokumenter og links

10.1039/A708801I

http://pubs.rsc.org/en/content/articlelanding/1998/p1/a708801i#!divAbstract

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Pfundheller, H. M., Jørgensen, P. N., Sørensen, U. S., Sharma, S. K., Grimstrup, M., Ströch, C., Nielsen, P., Viswanadham, G., Olsen, C. E., & Wengel, J. (1998). Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides. Journal of the Chemical Society, Perkin Transactions 1, 1998(8), 1409-1422. https://doi.org/10.1039/A708801I

@article{00dbf340e45511dca57f000ea68e967b,

title = "Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides",

abstract = "The methyl glycoside derivatives 4, 6, 10 and 32 have been used as precursors for the synthesis of novel 3′-C-alkyl-modified α- and β-2′-deoxynucleosides. Using an alternative linear strategy, 3′-C-methyl- and 3′-C-azidomethyl-modified thymidines 16 and 17 have been synthesized. Hybridization experiments with oligodeoxynucleotides containing 3′-C-(3-hydroxypropyl)thymidine monomers are reported.",

author = "Pfundheller, {Henrik M.} and J{\o}rgensen, {Pia N.} and S{\o}rensen, {Ulrik S.} and Sharma, {Sunil K.} and Marie Grimstrup and Claudia Str{\"o}ch and Poul Nielsen and Garimella Viswanadham and Olsen, {Carl Erik} and Jesper Wengel",

year = "1998",

doi = "10.1039/A708801I",

language = "English",

volume = "1998",

pages = "1409--1422",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

issn = "1472-7781",

publisher = "Chemical Society",

number = "8",

}

Pfundheller, HM, Jørgensen, PN, Sørensen, US, Sharma, SK, Grimstrup, M, Ströch, C, Nielsen, P, Viswanadham, G, Olsen, CE & Wengel, J 1998, 'Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides', Journal of the Chemical Society, Perkin Transactions 1, bind 1998, nr. 8, s. 1409-1422. https://doi.org/10.1039/A708801I

Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides. / Pfundheller, Henrik M.; Jørgensen, Pia N.; Sørensen, Ulrik S. et al.
I: Journal of the Chemical Society, Perkin Transactions 1, Bind 1998, Nr. 8, 1998, s. 1409-1422.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

AU - Pfundheller, Henrik M.

AU - Jørgensen, Pia N.

AU - Sørensen, Ulrik S.

AU - Sharma, Sunil K.

AU - Grimstrup, Marie

AU - Ströch, Claudia

AU - Nielsen, Poul

AU - Viswanadham, Garimella

AU - Olsen, Carl Erik

AU - Wengel, Jesper

PY - 1998

Y1 - 1998

N2 - The methyl glycoside derivatives 4, 6, 10 and 32 have been used as precursors for the synthesis of novel 3′-C-alkyl-modified α- and β-2′-deoxynucleosides. Using an alternative linear strategy, 3′-C-methyl- and 3′-C-azidomethyl-modified thymidines 16 and 17 have been synthesized. Hybridization experiments with oligodeoxynucleotides containing 3′-C-(3-hydroxypropyl)thymidine monomers are reported.

AB - The methyl glycoside derivatives 4, 6, 10 and 32 have been used as precursors for the synthesis of novel 3′-C-alkyl-modified α- and β-2′-deoxynucleosides. Using an alternative linear strategy, 3′-C-methyl- and 3′-C-azidomethyl-modified thymidines 16 and 17 have been synthesized. Hybridization experiments with oligodeoxynucleotides containing 3′-C-(3-hydroxypropyl)thymidine monomers are reported.

U2 - 10.1039/A708801I

DO - 10.1039/A708801I

M3 - Journal article

SN - 1472-7781

VL - 1998

SP - 1409

EP - 1422

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 8

ER -

Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

Abstract

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater