Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

Henrik M. Pfundheller, Pia N. Jørgensen, Ulrik S. Sørensen, Sunil K. Sharma, Marie Grimstrup, Claudia Ströch, Poul Nielsen, Garimella Viswanadham, Carl Erik Olsen, Jesper Wengel

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Abstract

    The methyl glycoside derivatives 4, 6, 10 and 32 have been used as precursors for the synthesis of novel 3′-C-alkyl-modified α- and β-2′-deoxynucleosides. Using an alternative linear strategy, 3′-C-methyl- and 3′-C-azidomethyl-modified thymidines 16 and 17 have been synthesized. Hybridization experiments with oligodeoxynucleotides containing 3′-C-(3-hydroxypropyl)thymidine monomers are reported.

    OriginalsprogEngelsk
    TidsskriftJournal of the Chemical Society, Perkin Transactions 1
    Vol/bind1998
    Udgave nummer8
    Sider (fra-til)1409-1422
    ISSN1472-7781
    DOI
    StatusUdgivet - 1998

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides'. Sammen danner de et unikt fingeraftryk.

    Citationsformater