Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes: X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent

Dimitris Matiadis, Dimitrios Tsironis, Valentina Stefanou, Alysha G Elliott, Konstantinos Kordatos, Georgia Zahariou, Nikolaos Ioannidis, Vickie McKee, Angeliki Panagiotopoulou, Olga Igglessi-Markopoulou, John Markopoulos

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Abstrakt

This study aims at the further expansion of knowledge on the antimicrobial activities of the tetramic acid moiety and the effect of metal complexation. Complexes of the N-acetyl-3-acetyl-5-benzylidenetetramic acid with Mn, Co, Ni, Cu, Zn and Cd were synthesized and screened against 5 key ESKAPE pathogens (Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) and 2 fungi (Cryptococcus neoformans and Candida albicans). The cadmium complex was found to effectively inhibit the fungus Cryptococcus neoformans with minimum inhibitory concentration (MIC) of 8 μg/mL, with no human cell toxicity and hemolytic activity within the tested concentration range. The biologically active tetramic acid‑cadmium complex was structurally characterized by single-crystal X-ray analysis. Furthermore, the thermal stability of the ligand and the complexes was investigated along with NMR and EPR studies of the Cd(II) and Co(II) complexes respectively.

OriginalsprogEngelsk
TidsskriftJournal of Inorganic Biochemistry
Vol/bind194
Udgave nummerMay
Sider (fra-til)65-73
ISSN0162-0134
DOI
StatusUdgivet - maj 2019

Bibliografisk note

Copyright © 2019 Elsevier Inc. All rights reserved.

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