Synthesis and anti-angiogenic effect of conjugates between serum albumin and non-steroidal anti-inflammatory drugs

Birgitte Kjær, Casper Struve, Tina Friis, Anne-Marie Engel, Natascha Helena Beyer, Peter Højrup, Gunnar Houen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit tumor growth and angiogenesis. Covalent linkage of naproxen to human serum albumin (HSA) has been shown to target it efficiently to the liver and this may potentially be exploited for liver-selective inhibition of angiogenesis. With the aim of investigating the anti-angiogenic efficiency of NSAID-HSA conjugates in vitro, three NSAIDs, aspirin, ibuprofen, and naproxen were conjugated to HSA using different concentrations of their N-hydroxysuccinimide esters. Conjugation ratios from 10 to 50 were achieved and the conjugates retained a growth inhibitory effect on endothelial cells at or above the level of the non-conjugated NSAIDs in an in vitro angiogenesis assay.
OriginalsprogEngelsk
TidsskriftProtein and Peptide Letters
Vol/bind17
Udgave nummer1
Sider (fra-til)121-130
Antal sider10
ISSN0929-8665
DOI
StatusUdgivet - 1. jan. 2010

Fingeraftryk

Dyk ned i forskningsemnerne om 'Synthesis and anti-angiogenic effect of conjugates between serum albumin and non-steroidal anti-inflammatory drugs'. Sammen danner de et unikt fingeraftryk.

Citationsformater