Synergistic enhancement of chemokine generation and lung injury by C5a or the membrane attack complex of complement

B J Czermak, A B Lentsch, N M Bless, H Schmal, H P Friedl, P A Ward

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Complement plays an important role in many acute inflammatory responses. In the current studies it was demonstrated that, in the presence of either C5a or sublytic forms of the complement-derived membrane attack complex (MAC), rat alveolar macrophages costimulated with IgG immune complexes demonstrated synergistic production of C-X-C (macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant) and C-C (macrophage inflammatory protein-1alpha and monocyte chemoattractant-1) chemokines. In the absence of the costimulus, C5a or MAC did not induce chemokine generation. In in vivo studies, C5a and MAC alone caused limited or no intrapulmonary generation of chemokines, but in the presence of a costimulus (IgG immune complexes) C5a and MAC caused synergistic intrapulmonary generation of C-X-C and C-C chemokines but not of tumor necrosis factor alpha. Under these conditions increased neutrophil accumulation occurred, as did lung injury. These observations suggest that C5a and MAC function synergistically with a costimulus to enhance chemokine generation and the intensity of the lung inflammatory response.

OriginalsprogEngelsk
TidsskriftThe American Journal of Pathology
Vol/bind154
Udgave nummer5
Sider (fra-til)1513-24
Antal sider12
ISSN0002-9440
DOI
StatusUdgivet - maj 1999

Fingeraftryk Dyk ned i forskningsemnerne om 'Synergistic enhancement of chemokine generation and lung injury by C5a or the membrane attack complex of complement'. Sammen danner de et unikt fingeraftryk.

Citationsformater