Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains

Jens D. Mikkelsen*, Sif Kaad, Sanjay S. Aripaka, Bente Finsen

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Histological and biochemical analyses in postmortem tissues have demonstrated neurodegenerative changes in the cerebral cortex in patients with Alzheimer's disease (AD), and it has been suggested that this represents a loss of synapses. PET imaging of the (pre)synaptic vesicular glycoprotein 2A (SV2A) has demonstrated a reduction in synapse density in AD in the hippocampus but not consistently in the neocortex. This investigation examines the level of [3H]UCB-J binding in postmortem cortical tissue from patients with AD and matched healthy controls using autoradiography. Among the neocortical areas examined, the binding was significantly lower only in the middle frontal gyrus in AD compared to matched controls. No differences were observed in the parietal, temporal, or occipital cortex. The binding levels in the frontal cortex in the AD cohort displayed large variability among subjects, and this revealed a highly significant negative association with the age of the patient. These results demonstrate low UCB-J binding in the frontal cortex of patients with AD, and this biomarker correlates negatively with age, which may further indicate that SV2A could be an important biomarker in AD patients.

OriginalsprogEngelsk
TidsskriftNeurobiology of Aging
Vol/bind129
Sider (fra-til)50-57
ISSN0197-4580
DOI
StatusUdgivet - sep. 2023

Bibliografisk note

Funding Information:
The authors like to thank the Netherlands Brain Bank for providing us with the tissue used in the present study.

Publisher Copyright:
© 2023 Elsevier Inc.

Fingeraftryk

Dyk ned i forskningsemnerne om 'Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains'. Sammen danner de et unikt fingeraftryk.

Citationsformater