Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study

M C Adriaanse, J M Dekker, R. J. Heine, Frank J Snoek, A J Beekman, C D A Stehouwer, L M Bouter, G Nijpels, F Pouwer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: To study the prevalence and risk factors of depressive symptoms, comparing subjects with normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or Type 2 diabetes mellitus (DM2).

RESEARCH DESIGN AND METHODS: Cross-sectional data from a population-based cohort study conducted among 550 residents (276 men and 274 women) of the Hoorn region, the Netherlands. Levels of depressive symptoms were measured using the Centre for Epidemiologic Studies Depression Scale (CES-D score > or = 16). Glucose metabolism status was determined by means of fasting and post-load glucose levels.

RESULTS: The prevalence of depressive symptoms in men with NGM, IGM and DM2 was 7.7, 7.0 and 15.0% (P = 0.19) and for women 7.7, 23.1 and 19.7% (P < 0.01), respectively. Depression was significantly more common in women with IGM [odds ratio (OR) = 3.60, 95% confidence interval (CI) = 1.57 to 8.28] and women with DM2 (OR = 3.18, 95% CI = 1.31 to 7.74). In men, depression was not associated with IGM (OR = 0.90, 95% CI = 0.32 to 2.57) and non-significantly more common in DM2 (OR = 2.04, 95% CI = 0.75 to 5.49). Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms reduced the strength of these associations.

CONCLUSIONS: Depressive symptoms are more common in women with IGM, but not men. Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms partially attenuated these associations, suggesting that these variables could be intermediate factors.

OriginalsprogEngelsk
TidsskriftDiabetic Medicine Online
Vol/bind25
Udgave nummer7
Sider (fra-til)843-9
Antal sider7
ISSN1464-5491
DOI
StatusUdgivet - jul. 2008

Fingeraftryk

Type 2 Diabetes Mellitus
Depression
Odds Ratio
Confidence Intervals
Netherlands
Epidemiologic Studies
Fasting
Cohort Studies
Research Design
Cross-Sectional Studies
Population

Citer dette

Adriaanse, M C ; Dekker, J M ; Heine, R. J. ; Snoek, Frank J ; Beekman, A J ; Stehouwer, C D A ; Bouter, L M ; Nijpels, G ; Pouwer, F. / Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus : The Hoorn Study. I: Diabetic Medicine Online. 2008 ; Bind 25, Nr. 7. s. 843-9.
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title = "Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study",
abstract = "OBJECTIVE: To study the prevalence and risk factors of depressive symptoms, comparing subjects with normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or Type 2 diabetes mellitus (DM2).RESEARCH DESIGN AND METHODS: Cross-sectional data from a population-based cohort study conducted among 550 residents (276 men and 274 women) of the Hoorn region, the Netherlands. Levels of depressive symptoms were measured using the Centre for Epidemiologic Studies Depression Scale (CES-D score > or = 16). Glucose metabolism status was determined by means of fasting and post-load glucose levels.RESULTS: The prevalence of depressive symptoms in men with NGM, IGM and DM2 was 7.7, 7.0 and 15.0{\%} (P = 0.19) and for women 7.7, 23.1 and 19.7{\%} (P < 0.01), respectively. Depression was significantly more common in women with IGM [odds ratio (OR) = 3.60, 95{\%} confidence interval (CI) = 1.57 to 8.28] and women with DM2 (OR = 3.18, 95{\%} CI = 1.31 to 7.74). In men, depression was not associated with IGM (OR = 0.90, 95{\%} CI = 0.32 to 2.57) and non-significantly more common in DM2 (OR = 2.04, 95{\%} CI = 0.75 to 5.49). Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms reduced the strength of these associations.CONCLUSIONS: Depressive symptoms are more common in women with IGM, but not men. Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms partially attenuated these associations, suggesting that these variables could be intermediate factors.",
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Adriaanse, MC, Dekker, JM, Heine, RJ, Snoek, FJ, Beekman, AJ, Stehouwer, CDA, Bouter, LM, Nijpels, G & Pouwer, F 2008, 'Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus: The Hoorn Study', Diabetic Medicine Online, bind 25, nr. 7, s. 843-9. https://doi.org/10.1111/j.1464-5491.2008.02464.x

Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus : The Hoorn Study. / Adriaanse, M C; Dekker, J M; Heine, R. J.; Snoek, Frank J; Beekman, A J; Stehouwer, C D A; Bouter, L M; Nijpels, G; Pouwer, F.

I: Diabetic Medicine Online, Bind 25, Nr. 7, 07.2008, s. 843-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Symptoms of depression in people with impaired glucose metabolism or Type 2 diabetes mellitus

T2 - The Hoorn Study

AU - Adriaanse, M C

AU - Dekker, J M

AU - Heine, R. J.

AU - Snoek, Frank J

AU - Beekman, A J

AU - Stehouwer, C D A

AU - Bouter, L M

AU - Nijpels, G

AU - Pouwer, F

PY - 2008/7

Y1 - 2008/7

N2 - OBJECTIVE: To study the prevalence and risk factors of depressive symptoms, comparing subjects with normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or Type 2 diabetes mellitus (DM2).RESEARCH DESIGN AND METHODS: Cross-sectional data from a population-based cohort study conducted among 550 residents (276 men and 274 women) of the Hoorn region, the Netherlands. Levels of depressive symptoms were measured using the Centre for Epidemiologic Studies Depression Scale (CES-D score > or = 16). Glucose metabolism status was determined by means of fasting and post-load glucose levels.RESULTS: The prevalence of depressive symptoms in men with NGM, IGM and DM2 was 7.7, 7.0 and 15.0% (P = 0.19) and for women 7.7, 23.1 and 19.7% (P < 0.01), respectively. Depression was significantly more common in women with IGM [odds ratio (OR) = 3.60, 95% confidence interval (CI) = 1.57 to 8.28] and women with DM2 (OR = 3.18, 95% CI = 1.31 to 7.74). In men, depression was not associated with IGM (OR = 0.90, 95% CI = 0.32 to 2.57) and non-significantly more common in DM2 (OR = 2.04, 95% CI = 0.75 to 5.49). Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms reduced the strength of these associations.CONCLUSIONS: Depressive symptoms are more common in women with IGM, but not men. Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms partially attenuated these associations, suggesting that these variables could be intermediate factors.

AB - OBJECTIVE: To study the prevalence and risk factors of depressive symptoms, comparing subjects with normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or Type 2 diabetes mellitus (DM2).RESEARCH DESIGN AND METHODS: Cross-sectional data from a population-based cohort study conducted among 550 residents (276 men and 274 women) of the Hoorn region, the Netherlands. Levels of depressive symptoms were measured using the Centre for Epidemiologic Studies Depression Scale (CES-D score > or = 16). Glucose metabolism status was determined by means of fasting and post-load glucose levels.RESULTS: The prevalence of depressive symptoms in men with NGM, IGM and DM2 was 7.7, 7.0 and 15.0% (P = 0.19) and for women 7.7, 23.1 and 19.7% (P < 0.01), respectively. Depression was significantly more common in women with IGM [odds ratio (OR) = 3.60, 95% confidence interval (CI) = 1.57 to 8.28] and women with DM2 (OR = 3.18, 95% CI = 1.31 to 7.74). In men, depression was not associated with IGM (OR = 0.90, 95% CI = 0.32 to 2.57) and non-significantly more common in DM2 (OR = 2.04, 95% CI = 0.75 to 5.49). Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms reduced the strength of these associations.CONCLUSIONS: Depressive symptoms are more common in women with IGM, but not men. Adjustment for cardiovascular risk factors, cardiovascular disease and diabetes symptoms partially attenuated these associations, suggesting that these variables could be intermediate factors.

KW - Aged

KW - Blood Glucose

KW - Cross-Sectional Studies

KW - Depressive Disorder

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Glucose Intolerance

KW - Humans

KW - Male

KW - Middle Aged

KW - Netherlands

KW - Prevalence

KW - Risk Factors

KW - Sex Distribution

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1464-5491.2008.02464.x

DO - 10.1111/j.1464-5491.2008.02464.x

M3 - Journal article

C2 - 18513303

VL - 25

SP - 843

EP - 849

JO - Diabetic Medicine Online

JF - Diabetic Medicine Online

SN - 1464-5491

IS - 7

ER -