Survival after blood transfusion

Mads Kamper-Jørgensen, Martin Ahlgren, Klaus Rostgaard, Mads Melbye, Gustaf Edgren, Olof Nyrén, Marie Reilly, Rut Norda, Kjell Titlestad, Elsa Tynell, Henrik Hjalgrim

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2008-Dec
OriginalsprogEngelsk
TidsskriftTransfusion
Vol/bind48
Udgave nummer12
Sider (fra-til)2577-84
Antal sider7
ISSN0041-1132
DOI
StatusUdgivet - 1. dec. 2008

Fingeraftryk

Population
Denmark
Internal Medicine
Cost-Benefit Analysis
Cohort Studies
Outcome Assessment (Health Care)

Citer dette

Kamper-Jørgensen, M., Ahlgren, M., Rostgaard, K., Melbye, M., Edgren, G., Nyrén, O., ... Hjalgrim, H. (2008). Survival after blood transfusion. Transfusion, 48(12), 2577-84. https://doi.org/10.1111/j.1537-2995.2008.01881.x
Kamper-Jørgensen, Mads ; Ahlgren, Martin ; Rostgaard, Klaus ; Melbye, Mads ; Edgren, Gustaf ; Nyrén, Olof ; Reilly, Marie ; Norda, Rut ; Titlestad, Kjell ; Tynell, Elsa ; Hjalgrim, Henrik. / Survival after blood transfusion. I: Transfusion. 2008 ; Bind 48, Nr. 12. s. 2577-84.
@article{80daeee0e22211dd990a000ea68e967b,
title = "Survival after blood transfusion",
abstract = "BACKGROUND: Long-term survival of transfusion recipients has rarely been studied. This study examines short- and long-term mortality among transfusion recipients and reports these as absolute rates and rates relative to the general population. STUDY DESIGN AND METHODS: Population-based cohort study of transfusion recipients in Denmark and Sweden followed for up to 20 years after their first blood transfusion. Main outcome measure was all-cause mortality. RESULTS: A total of 1,118,261 transfusion recipients were identified, of whom 62.0 percent were aged 65 years or older at the time of their first registered transfusion. Three months after the first transfusion, 84.3 percent of recipients were alive. One-, 5-, and 20-year posttransfusion survival was 73.7, 53.4, and 27.0 percent, respectively. Survival was slightly poorer in men than in women, decreased with increasing age, and was worst for recipients transfused at departments of internal medicine. The first 3 months after the first transfusion, the standardized mortality ratio (SMR) was 17.6 times higher in transfusion recipients than in the general population. One to 4 years after first transfusion, the SMR was 2.1 and even after 17 years the SMR remained significantly 1.3-fold increased. CONCLUSION: The survival and relative mortality patterns among blood transfusion recipients were characterized with unprecedented detail and precision. Our results are relevant to assessments of the consequences of possible transfusion-transmitted disease as well as for cost-benefit estimation of new blood safety interventions.",
keywords = "Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Blood Transfusion, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Middle Aged, Survival Rate, Time Factors",
author = "Mads Kamper-J{\o}rgensen and Martin Ahlgren and Klaus Rostgaard and Mads Melbye and Gustaf Edgren and Olof Nyr{\'e}n and Marie Reilly and Rut Norda and Kjell Titlestad and Elsa Tynell and Henrik Hjalgrim",
year = "2008",
month = "12",
day = "1",
doi = "10.1111/j.1537-2995.2008.01881.x",
language = "English",
volume = "48",
pages = "2577--84",
journal = "Transfusion",
issn = "0041-1132",
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}

Kamper-Jørgensen, M, Ahlgren, M, Rostgaard, K, Melbye, M, Edgren, G, Nyrén, O, Reilly, M, Norda, R, Titlestad, K, Tynell, E & Hjalgrim, H 2008, 'Survival after blood transfusion', Transfusion, bind 48, nr. 12, s. 2577-84. https://doi.org/10.1111/j.1537-2995.2008.01881.x

Survival after blood transfusion. / Kamper-Jørgensen, Mads; Ahlgren, Martin; Rostgaard, Klaus; Melbye, Mads; Edgren, Gustaf; Nyrén, Olof; Reilly, Marie; Norda, Rut; Titlestad, Kjell; Tynell, Elsa; Hjalgrim, Henrik.

I: Transfusion, Bind 48, Nr. 12, 01.12.2008, s. 2577-84.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Survival after blood transfusion

AU - Kamper-Jørgensen, Mads

AU - Ahlgren, Martin

AU - Rostgaard, Klaus

AU - Melbye, Mads

AU - Edgren, Gustaf

AU - Nyrén, Olof

AU - Reilly, Marie

AU - Norda, Rut

AU - Titlestad, Kjell

AU - Tynell, Elsa

AU - Hjalgrim, Henrik

PY - 2008/12/1

Y1 - 2008/12/1

N2 - BACKGROUND: Long-term survival of transfusion recipients has rarely been studied. This study examines short- and long-term mortality among transfusion recipients and reports these as absolute rates and rates relative to the general population. STUDY DESIGN AND METHODS: Population-based cohort study of transfusion recipients in Denmark and Sweden followed for up to 20 years after their first blood transfusion. Main outcome measure was all-cause mortality. RESULTS: A total of 1,118,261 transfusion recipients were identified, of whom 62.0 percent were aged 65 years or older at the time of their first registered transfusion. Three months after the first transfusion, 84.3 percent of recipients were alive. One-, 5-, and 20-year posttransfusion survival was 73.7, 53.4, and 27.0 percent, respectively. Survival was slightly poorer in men than in women, decreased with increasing age, and was worst for recipients transfused at departments of internal medicine. The first 3 months after the first transfusion, the standardized mortality ratio (SMR) was 17.6 times higher in transfusion recipients than in the general population. One to 4 years after first transfusion, the SMR was 2.1 and even after 17 years the SMR remained significantly 1.3-fold increased. CONCLUSION: The survival and relative mortality patterns among blood transfusion recipients were characterized with unprecedented detail and precision. Our results are relevant to assessments of the consequences of possible transfusion-transmitted disease as well as for cost-benefit estimation of new blood safety interventions.

AB - BACKGROUND: Long-term survival of transfusion recipients has rarely been studied. This study examines short- and long-term mortality among transfusion recipients and reports these as absolute rates and rates relative to the general population. STUDY DESIGN AND METHODS: Population-based cohort study of transfusion recipients in Denmark and Sweden followed for up to 20 years after their first blood transfusion. Main outcome measure was all-cause mortality. RESULTS: A total of 1,118,261 transfusion recipients were identified, of whom 62.0 percent were aged 65 years or older at the time of their first registered transfusion. Three months after the first transfusion, 84.3 percent of recipients were alive. One-, 5-, and 20-year posttransfusion survival was 73.7, 53.4, and 27.0 percent, respectively. Survival was slightly poorer in men than in women, decreased with increasing age, and was worst for recipients transfused at departments of internal medicine. The first 3 months after the first transfusion, the standardized mortality ratio (SMR) was 17.6 times higher in transfusion recipients than in the general population. One to 4 years after first transfusion, the SMR was 2.1 and even after 17 years the SMR remained significantly 1.3-fold increased. CONCLUSION: The survival and relative mortality patterns among blood transfusion recipients were characterized with unprecedented detail and precision. Our results are relevant to assessments of the consequences of possible transfusion-transmitted disease as well as for cost-benefit estimation of new blood safety interventions.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Blood Transfusion

KW - Child

KW - Child, Preschool

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Middle Aged

KW - Survival Rate

KW - Time Factors

U2 - 10.1111/j.1537-2995.2008.01881.x

DO - 10.1111/j.1537-2995.2008.01881.x

M3 - Journal article

C2 - 18673342

VL - 48

SP - 2577

EP - 2584

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 12

ER -

Kamper-Jørgensen M, Ahlgren M, Rostgaard K, Melbye M, Edgren G, Nyrén O et al. Survival after blood transfusion. Transfusion. 2008 dec 1;48(12):2577-84. https://doi.org/10.1111/j.1537-2995.2008.01881.x