TY - JOUR
T1 - Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019
AU - Hammerum, Anette M.
AU - Justesen, Ulrik S.
AU - Pinholt, Mette
AU - Roer, Louise
AU - Kaya, Hülya
AU - Worning, Peder
AU - Nygaard, Sanne
AU - Kemp, Michael
AU - Clausen, Marianne Engell
AU - Nielsen, Karen Leth
AU - Samulioniené, Jurgita
AU - Kjærsgaard, Mona
AU - Østergaard, Claus
AU - Coia, John
AU - Søndergaard, Turid Snekloth
AU - Gaini, Shahin
AU - Schønning, Kristian
AU - Westh, Henrik
AU - Hasman, Henrik
AU - Holzknecht, Barbara Juliane
PY - 2019/8/22
Y1 - 2019/8/22
N2 - We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.
AB - We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.
KW - Enterococci
KW - MLST
KW - vanA
KW - vanB
KW - VRE
KW - VVE
KW - Prevalence
KW - Humans
KW - Multilocus Sequence Typing
KW - Anti-Bacterial Agents/pharmacology
KW - Electrophoresis, Gel, Pulsed-Field
KW - Sequence Analysis, DNA
KW - Gram-Positive Bacterial Infections/epidemiology
KW - Enterococcus faecium/drug effects
KW - Microbial Sensitivity Tests
KW - Denmark/epidemiology
KW - Bacterial Proteins/genetics
KW - Polymerase Chain Reaction
KW - Vancomycin/pharmacology
KW - Carbon-Oxygen Ligases
KW - DNA, Bacterial/genetics
KW - Sentinel Surveillance
KW - Vancomycin-Resistant Enterococci/drug effects
U2 - 10.2807/1560-7917.ES.2019.24.34.1900503
DO - 10.2807/1560-7917.ES.2019.24.34.1900503
M3 - Journal article
C2 - 31456560
AN - SCOPUS:85071651705
VL - 24
JO - Eurosurveillance
JF - Eurosurveillance
SN - 1025-496X
IS - 34
M1 - 1900503
ER -