Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease

Sofie Lock Johansson; J. Vestbo; G. L. Sorensen

doi:10.1186/s12931-014-0147-5

Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease

Kardiovaskulær & Renalforskning

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be fully described by the severity of airway obstruction. The limitations of spirometry and clinical history have prompted researchers to investigate a multitude of surrogate biomarkers of disease for the assessment of patients, prediction of risk, and guidance of treatment. The aim of this review is to provide a comprehensive summary of observations for a selection of recently investigated pulmonary inflammatory biomarkers (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive protein (CRP) and fibrinogen) with COPD. The relevance of these biomarkers for COPD is discussed in terms of their biological plausibility, their independent association to disease and hard clinical outcomes, their modification by interventions, and whether changes in clinical outcomes are reflected by changes in the biomarker.

Originalsprog	Engelsk
Artikelnummer	147
Tidsskrift	Respiratory Research
Vol/bind	15
Sider (fra-til)	10
ISSN	1465-993X
DOI	https://doi.org/10.1186/s12931-014-0147-5
Status	Udgivet - 25. nov. 2014

Bibliografisk note

ISI Document Delivery No.: AY2PY Times Cited: 0 Cited Reference Count: 127 Lock-Johansson, Sofie Vestbo, Jorgen Sorensen, Grith Lykke Region of Southern Denmark, Odense University Hospital Research Council; Danish Strategic Research Council, Centre of COPD research [09-066945]; Danish Lung Association Funding was obtained from the Region of Southern Denmark, Odense University Hospital Research Council, the Danish Strategic Research Council, Centre of COPD research (www.cekol.dk) (09-066945), the Danish Lung Association. 0 BIOMED CENTRAL LTD LONDON RESP RES

Emneord

COPD Biomarker SP-D CC-16 PARC/CCL-18 CRP Fibrinogen SYSTEMIC INFLAMMATION CARDIOVASCULAR-DISEASE PLASMA-FIBRINOGEN SERUM-LEVELS ACUTE EXACERBATIONS BLOOD BIOMARKERS BRONCHOALVEOLAR LAVAGE ALVEOLAR MACROPHAGES CIGARETTE-SMOKING FUNCTION DECLINE

Dokumenter og links

10.1186/s12931-014-0147-5

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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abstract = "Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be fully described by the severity of airway obstruction. The limitations of spirometry and clinical history have prompted researchers to investigate a multitude of surrogate biomarkers of disease for the assessment of patients, prediction of risk, and guidance of treatment. The aim of this review is to provide a comprehensive summary of observations for a selection of recently investigated pulmonary inflammatory biomarkers (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive protein (CRP) and fibrinogen) with COPD. The relevance of these biomarkers for COPD is discussed in terms of their biological plausibility, their independent association to disease and hard clinical outcomes, their modification by interventions, and whether changes in clinical outcomes are reflected by changes in the biomarker.",

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note = "ISI Document Delivery No.: AY2PY Times Cited: 0 Cited Reference Count: 127 Lock-Johansson, Sofie Vestbo, Jorgen Sorensen, Grith Lykke Region of Southern Denmark, Odense University Hospital Research Council; Danish Strategic Research Council, Centre of COPD research [09-066945]; Danish Lung Association Funding was obtained from the Region of Southern Denmark, Odense University Hospital Research Council, the Danish Strategic Research Council, Centre of COPD research (www.cekol.dk) (09-066945), the Danish Lung Association. 0 BIOMED CENTRAL LTD LONDON RESP RES",

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Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease. / Johansson, Sofie Lock; Vestbo, J.; Sorensen, G. L.
I: Respiratory Research, Bind 15, 147, 25.11.2014, s. 10.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease

AU - Johansson, Sofie Lock

AU - Vestbo, J.

AU - Sorensen, G. L.

N1 - ISI Document Delivery No.: AY2PY Times Cited: 0 Cited Reference Count: 127 Lock-Johansson, Sofie Vestbo, Jorgen Sorensen, Grith Lykke Region of Southern Denmark, Odense University Hospital Research Council; Danish Strategic Research Council, Centre of COPD research [09-066945]; Danish Lung Association Funding was obtained from the Region of Southern Denmark, Odense University Hospital Research Council, the Danish Strategic Research Council, Centre of COPD research (www.cekol.dk) (09-066945), the Danish Lung Association. 0 BIOMED CENTRAL LTD LONDON RESP RES

PY - 2014/11/25

Y1 - 2014/11/25

N2 - Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be fully described by the severity of airway obstruction. The limitations of spirometry and clinical history have prompted researchers to investigate a multitude of surrogate biomarkers of disease for the assessment of patients, prediction of risk, and guidance of treatment. The aim of this review is to provide a comprehensive summary of observations for a selection of recently investigated pulmonary inflammatory biomarkers (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive protein (CRP) and fibrinogen) with COPD. The relevance of these biomarkers for COPD is discussed in terms of their biological plausibility, their independent association to disease and hard clinical outcomes, their modification by interventions, and whether changes in clinical outcomes are reflected by changes in the biomarker.

AB - Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be fully described by the severity of airway obstruction. The limitations of spirometry and clinical history have prompted researchers to investigate a multitude of surrogate biomarkers of disease for the assessment of patients, prediction of risk, and guidance of treatment. The aim of this review is to provide a comprehensive summary of observations for a selection of recently investigated pulmonary inflammatory biomarkers (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive protein (CRP) and fibrinogen) with COPD. The relevance of these biomarkers for COPD is discussed in terms of their biological plausibility, their independent association to disease and hard clinical outcomes, their modification by interventions, and whether changes in clinical outcomes are reflected by changes in the biomarker.

KW - COPD Biomarker SP-D CC-16 PARC/CCL-18 CRP Fibrinogen SYSTEMIC INFLAMMATION CARDIOVASCULAR-DISEASE PLASMA-FIBRINOGEN SERUM-LEVELS ACUTE EXACERBATIONS BLOOD BIOMARKERS BRONCHOALVEOLAR LAVAGE ALVEOLAR MACROPHAGES CIGARETTE-SMOKING FUNCTION DECLINE

KW - Biomarker

KW - CC-16

KW - COPD

KW - CRP

KW - Fibrinogen

KW - PARC/CCL-18

KW - SP-D

U2 - 10.1186/s12931-014-0147-5

DO - 10.1186/s12931-014-0147-5

M3 - Journal article

C2 - 25425298

SN - 1465-993X

VL - 15

SP - 10

JO - Respiratory Research

JF - Respiratory Research

M1 - 147

ER -