Surfactant protein D augments bacterial association but attenuates major histocompatibility complex class II presentation of bacterial antigens

Søren Hansen, Bernice Lo, Kathy Evans, Pavlos Neophytou, Uffe Holmskov, Jo Rae Wright

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
Udgivelsesdato: Jan
OriginalsprogEngelsk
TidsskriftAmerican Journal of Respiratory Cell and Molecular Biology
Vol/bind36
Udgave nummer1
Sider (fra-til)94-102
Antal sider8
ISSN1044-1549
DOI
StatusUdgivet - 1. jan. 2006

Fingeraftryk

Pulmonary Surfactant-Associated Protein D
Bacterial Antigens
Alzheimer Disease
Lipids
Lectins
Regression analysis
Logistics
Hazards
Homeostasis
Logistic Models
Smoking
Odds Ratio
Regression Analysis

Citer dette

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title = "Surfactant protein D augments bacterial association but attenuates major histocompatibility complex class II presentation of bacterial antigens",
abstract = "Development of dementia, including Alzheimer's disease (AD), is associated with lipid dysregulation and inflammation. As the host defense lectin surfactant protein D (SP-D) has multiple effects in lipid homeostasis and inflammation, the correlation between SP-D concentrations and development of dementia was investigated. A total of 418 non-demented persons were included in the study and cognitively re-examined after 3 years, while survival was followed for 11 years. Serum SP-D concentrations were measured at baseline. Logistic regression analysis controlling for age, gender, smoking status, and CRP showed that Odds Ratio for developing dementia was 2.62 (1.12-6.15) with an SP-D concentration in the highest quartile compared to the other quartiles. The risk of AD was 2.55 (0.95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality.",
keywords = "Animals, Antigen Presentation, Antigens, Bacterial, Antigens, CD11, Bone Marrow Cells, Cells, Cultured, Dendritic Cells, Escherichia coli, Genes, MHC Class II, Lung, Mice, Mice, Inbred C57BL, Ovalbumin, Pulmonary Surfactant-Associated Protein D, Recombinant Proteins",
author = "S{\o}ren Hansen and Bernice Lo and Kathy Evans and Pavlos Neophytou and Uffe Holmskov and Wright, {Jo Rae}",
year = "2006",
month = "1",
day = "1",
doi = "10.1165/rcmb.2006-0195OC",
language = "English",
volume = "36",
pages = "94--102",
journal = "American Journal of Respiratory Cell and Molecular Biology",
issn = "1044-1549",
publisher = "American Thoracic Society",
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Surfactant protein D augments bacterial association but attenuates major histocompatibility complex class II presentation of bacterial antigens. / Hansen, Søren; Lo, Bernice; Evans, Kathy; Neophytou, Pavlos; Holmskov, Uffe; Wright, Jo Rae.

I: American Journal of Respiratory Cell and Molecular Biology, Bind 36, Nr. 1, 01.01.2006, s. 94-102.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Surfactant protein D augments bacterial association but attenuates major histocompatibility complex class II presentation of bacterial antigens

AU - Hansen, Søren

AU - Lo, Bernice

AU - Evans, Kathy

AU - Neophytou, Pavlos

AU - Holmskov, Uffe

AU - Wright, Jo Rae

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Development of dementia, including Alzheimer's disease (AD), is associated with lipid dysregulation and inflammation. As the host defense lectin surfactant protein D (SP-D) has multiple effects in lipid homeostasis and inflammation, the correlation between SP-D concentrations and development of dementia was investigated. A total of 418 non-demented persons were included in the study and cognitively re-examined after 3 years, while survival was followed for 11 years. Serum SP-D concentrations were measured at baseline. Logistic regression analysis controlling for age, gender, smoking status, and CRP showed that Odds Ratio for developing dementia was 2.62 (1.12-6.15) with an SP-D concentration in the highest quartile compared to the other quartiles. The risk of AD was 2.55 (0.95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality.

AB - Development of dementia, including Alzheimer's disease (AD), is associated with lipid dysregulation and inflammation. As the host defense lectin surfactant protein D (SP-D) has multiple effects in lipid homeostasis and inflammation, the correlation between SP-D concentrations and development of dementia was investigated. A total of 418 non-demented persons were included in the study and cognitively re-examined after 3 years, while survival was followed for 11 years. Serum SP-D concentrations were measured at baseline. Logistic regression analysis controlling for age, gender, smoking status, and CRP showed that Odds Ratio for developing dementia was 2.62 (1.12-6.15) with an SP-D concentration in the highest quartile compared to the other quartiles. The risk of AD was 2.55 (0.95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality.

KW - Animals

KW - Antigen Presentation

KW - Antigens, Bacterial

KW - Antigens, CD11

KW - Bone Marrow Cells

KW - Cells, Cultured

KW - Dendritic Cells

KW - Escherichia coli

KW - Genes, MHC Class II

KW - Lung

KW - Mice

KW - Mice, Inbred C57BL

KW - Ovalbumin

KW - Pulmonary Surfactant-Associated Protein D

KW - Recombinant Proteins

U2 - 10.1165/rcmb.2006-0195OC

DO - 10.1165/rcmb.2006-0195OC

M3 - Journal article

C2 - 16902193

VL - 36

SP - 94

EP - 102

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

SN - 1044-1549

IS - 1

ER -