Surface-functionalized mesoporous nanoparticles as heterogeneous supports to transfer bifunctional catalysts into organic solvents for tandem catalysis

Ningning Zhang, René Hübner, Yangxin Wang, En Zhang, Yujian Zhou, Shengyi Dong, Changzhu Wu

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

The combination of chemo- and biocatalysts offers a powerful platform to address synthetic challenges in chemistry, particularly in synthetic cascades. However, transferring both catalysts into organic solvents remains technically difficult because of the enzyme inactivation and catalyst precipitation. Herein, we designed a facile approach using functionalized mesoporous silica nanoparticles (MSN) to transfer chemo- and biocatalysts into a variety of organic solvents. As a proof-of-concept, two distinct catalysts, palladium nanoparticles (Pd NPs) and Candida antarctica lipase B (CalB), were stepwise loaded into separate locations of the mesoporous structure, which not only provided catalysts with heterogeneous supports for the recycling but also avoided their mutual inactivation. Moreover, mesoporous particles were hydrophobized by surface alkylation, resulting in a tailor-made particle hydrophobicity, which allowed bifunctional catalysts to be dispersed in eight organic solvents. Eventually, these attractive material properties provided the MSN-based bifunctional catalysts with remarkable catalytic performance for cascade reaction synthesizing benzyl hexanoate in toluene. With a broader perspective, the success of this study opens new avenues in the field of multifunctional catalysts where a plethora of other chemo- and biocatalysts can be incorporated into surface-functionalized materials ranging from soft matters to porous networks for synthetic purposes in organic solvents.
OriginalsprogEngelsk
TidsskriftACS Applied Nano Materials
Vol/bind1
Udgave nummer11
Sider (fra-til)6378–6386
ISSN2574-0970
DOI
StatusUdgivet - 2018

Fingeraftryk

Catalyst supports
Organic solvents
Catalysis
Nanoparticles
Catalysts
Enzymes
Silicon Dioxide
Alkylation
Toluene
Palladium
Hydrophobicity
Recycling
Materials properties

Citer dette

Zhang, Ningning ; Hübner, René ; Wang, Yangxin ; Zhang, En ; Zhou, Yujian ; Dong, Shengyi ; Wu, Changzhu. / Surface-functionalized mesoporous nanoparticles as heterogeneous supports to transfer bifunctional catalysts into organic solvents for tandem catalysis. I: ACS Applied Nano Materials. 2018 ; Bind 1, Nr. 11. s. 6378–6386.
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title = "Surface-functionalized mesoporous nanoparticles as heterogeneous supports to transfer bifunctional catalysts into organic solvents for tandem catalysis",
abstract = "The combination of chemo- and biocatalysts offers a powerful platform to address synthetic challenges in chemistry, particularly in synthetic cascades. However, transferring both catalysts into organic solvents remains technically difficult because of the enzyme inactivation and catalyst precipitation. Herein, we designed a facile approach using functionalized mesoporous silica nanoparticles (MSN) to transfer chemo- and biocatalysts into a variety of organic solvents. As a proof-of-concept, two distinct catalysts, palladium nanoparticles (Pd NPs) and Candida antarctica lipase B (CalB), were stepwise loaded into separate locations of the mesoporous structure, which not only provided catalysts with heterogeneous supports for the recycling but also avoided their mutual inactivation. Moreover, mesoporous particles were hydrophobized by surface alkylation, resulting in a tailor-made particle hydrophobicity, which allowed bifunctional catalysts to be dispersed in eight organic solvents. Eventually, these attractive material properties provided the MSN-based bifunctional catalysts with remarkable catalytic performance for cascade reaction synthesizing benzyl hexanoate in toluene. With a broader perspective, the success of this study opens new avenues in the field of multifunctional catalysts where a plethora of other chemo- and biocatalysts can be incorporated into surface-functionalized materials ranging from soft matters to porous networks for synthetic purposes in organic solvents.",
author = "Ningning Zhang and Ren{\'e} H{\"u}bner and Yangxin Wang and En Zhang and Yujian Zhou and Shengyi Dong and Changzhu Wu",
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Surface-functionalized mesoporous nanoparticles as heterogeneous supports to transfer bifunctional catalysts into organic solvents for tandem catalysis. / Zhang, Ningning; Hübner, René; Wang, Yangxin; Zhang, En; Zhou, Yujian; Dong, Shengyi ; Wu, Changzhu.

I: ACS Applied Nano Materials, Bind 1, Nr. 11, 2018, s. 6378–6386.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Surface-functionalized mesoporous nanoparticles as heterogeneous supports to transfer bifunctional catalysts into organic solvents for tandem catalysis

AU - Zhang, Ningning

AU - Hübner, René

AU - Wang, Yangxin

AU - Zhang, En

AU - Zhou, Yujian

AU - Dong, Shengyi

AU - Wu, Changzhu

PY - 2018

Y1 - 2018

N2 - The combination of chemo- and biocatalysts offers a powerful platform to address synthetic challenges in chemistry, particularly in synthetic cascades. However, transferring both catalysts into organic solvents remains technically difficult because of the enzyme inactivation and catalyst precipitation. Herein, we designed a facile approach using functionalized mesoporous silica nanoparticles (MSN) to transfer chemo- and biocatalysts into a variety of organic solvents. As a proof-of-concept, two distinct catalysts, palladium nanoparticles (Pd NPs) and Candida antarctica lipase B (CalB), were stepwise loaded into separate locations of the mesoporous structure, which not only provided catalysts with heterogeneous supports for the recycling but also avoided their mutual inactivation. Moreover, mesoporous particles were hydrophobized by surface alkylation, resulting in a tailor-made particle hydrophobicity, which allowed bifunctional catalysts to be dispersed in eight organic solvents. Eventually, these attractive material properties provided the MSN-based bifunctional catalysts with remarkable catalytic performance for cascade reaction synthesizing benzyl hexanoate in toluene. With a broader perspective, the success of this study opens new avenues in the field of multifunctional catalysts where a plethora of other chemo- and biocatalysts can be incorporated into surface-functionalized materials ranging from soft matters to porous networks for synthetic purposes in organic solvents.

AB - The combination of chemo- and biocatalysts offers a powerful platform to address synthetic challenges in chemistry, particularly in synthetic cascades. However, transferring both catalysts into organic solvents remains technically difficult because of the enzyme inactivation and catalyst precipitation. Herein, we designed a facile approach using functionalized mesoporous silica nanoparticles (MSN) to transfer chemo- and biocatalysts into a variety of organic solvents. As a proof-of-concept, two distinct catalysts, palladium nanoparticles (Pd NPs) and Candida antarctica lipase B (CalB), were stepwise loaded into separate locations of the mesoporous structure, which not only provided catalysts with heterogeneous supports for the recycling but also avoided their mutual inactivation. Moreover, mesoporous particles were hydrophobized by surface alkylation, resulting in a tailor-made particle hydrophobicity, which allowed bifunctional catalysts to be dispersed in eight organic solvents. Eventually, these attractive material properties provided the MSN-based bifunctional catalysts with remarkable catalytic performance for cascade reaction synthesizing benzyl hexanoate in toluene. With a broader perspective, the success of this study opens new avenues in the field of multifunctional catalysts where a plethora of other chemo- and biocatalysts can be incorporated into surface-functionalized materials ranging from soft matters to porous networks for synthetic purposes in organic solvents.

U2 - 10.1021/acsanm.8b01572

DO - 10.1021/acsanm.8b01572

M3 - Journal article

VL - 1

SP - 6378

EP - 6386

JO - ACS Applied Nano Materials

JF - ACS Applied Nano Materials

SN - 2574-0970

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