Suppressed phagocyte function in conditioned athletes

Maria Hondras, N. Steinke, P. C. Brennan

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Most athletes believe that resistance to infection is improved by exercise; however, supporting evidence is conflicting. Phagocytosis was evaluated in whole blood and isolated polymorphonuclear neutrophils (PMNs) from conditioned athletes before and after exercise using chemiluminescence (CL) as an index of cell function. Each subject performed for 20 minutes on a treadmill at 75% of training heart rate as calculated by Karvonen's formula and monitored by a Nacro physiograph. Blood was collected 24 hr and 15 min before and 30 min and 24 hr after exercise. Whole blood and isolated PMNs were tested using a standardized, optimized, automated CL methodology. There was no significant difference in total white blood cell count nor in absolute granulocytes before and after exercise. The CL response of isolated PMNs 30 min and 24 hr after exercise did not differ from pre-exercise level. On a per cell basis, CL was significantly suppressed at 30 min in whole blood (p < 0.01) and at 24 hr (p < 0.05) after exercise. The normal CL response in isolated PMNs coupled with suppressed CL in whole blood suggest that some serum factor(s) induced by exercise suppresses phagocytic cell function.

OriginalsprogEngelsk
TidsskriftChiropractic Sports Medicine
Vol/bind2
Udgave nummer4
Sider (fra-til)111-114
Antal sider4
ISSN0889-6976
StatusUdgivet - 1. dec. 1988
Udgivet eksterntJa

Fingeraftryk

Phagocytes
Athletes
Exercise
Neutrophils
Serum

Citer dette

Hondras, M., Steinke, N., & Brennan, P. C. (1988). Suppressed phagocyte function in conditioned athletes. Chiropractic Sports Medicine, 2(4), 111-114.
Hondras, Maria ; Steinke, N. ; Brennan, P. C. / Suppressed phagocyte function in conditioned athletes. I: Chiropractic Sports Medicine. 1988 ; Bind 2, Nr. 4. s. 111-114.
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Hondras, M, Steinke, N & Brennan, PC 1988, 'Suppressed phagocyte function in conditioned athletes', Chiropractic Sports Medicine, bind 2, nr. 4, s. 111-114.

Suppressed phagocyte function in conditioned athletes. / Hondras, Maria ; Steinke, N.; Brennan, P. C.

I: Chiropractic Sports Medicine, Bind 2, Nr. 4, 01.12.1988, s. 111-114.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Suppressed phagocyte function in conditioned athletes

AU - Hondras, Maria

AU - Steinke, N.

AU - Brennan, P. C.

PY - 1988/12/1

Y1 - 1988/12/1

N2 - Most athletes believe that resistance to infection is improved by exercise; however, supporting evidence is conflicting. Phagocytosis was evaluated in whole blood and isolated polymorphonuclear neutrophils (PMNs) from conditioned athletes before and after exercise using chemiluminescence (CL) as an index of cell function. Each subject performed for 20 minutes on a treadmill at 75% of training heart rate as calculated by Karvonen's formula and monitored by a Nacro physiograph. Blood was collected 24 hr and 15 min before and 30 min and 24 hr after exercise. Whole blood and isolated PMNs were tested using a standardized, optimized, automated CL methodology. There was no significant difference in total white blood cell count nor in absolute granulocytes before and after exercise. The CL response of isolated PMNs 30 min and 24 hr after exercise did not differ from pre-exercise level. On a per cell basis, CL was significantly suppressed at 30 min in whole blood (p < 0.01) and at 24 hr (p < 0.05) after exercise. The normal CL response in isolated PMNs coupled with suppressed CL in whole blood suggest that some serum factor(s) induced by exercise suppresses phagocytic cell function.

AB - Most athletes believe that resistance to infection is improved by exercise; however, supporting evidence is conflicting. Phagocytosis was evaluated in whole blood and isolated polymorphonuclear neutrophils (PMNs) from conditioned athletes before and after exercise using chemiluminescence (CL) as an index of cell function. Each subject performed for 20 minutes on a treadmill at 75% of training heart rate as calculated by Karvonen's formula and monitored by a Nacro physiograph. Blood was collected 24 hr and 15 min before and 30 min and 24 hr after exercise. Whole blood and isolated PMNs were tested using a standardized, optimized, automated CL methodology. There was no significant difference in total white blood cell count nor in absolute granulocytes before and after exercise. The CL response of isolated PMNs 30 min and 24 hr after exercise did not differ from pre-exercise level. On a per cell basis, CL was significantly suppressed at 30 min in whole blood (p < 0.01) and at 24 hr (p < 0.05) after exercise. The normal CL response in isolated PMNs coupled with suppressed CL in whole blood suggest that some serum factor(s) induced by exercise suppresses phagocytic cell function.

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JO - Chiropractic Sports Medicine

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SN - 0889-6976

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Hondras M, Steinke N, Brennan PC. Suppressed phagocyte function in conditioned athletes. Chiropractic Sports Medicine. 1988 dec 1;2(4):111-114.