Sudden unexpected death caused by stroke

A nationwide study among children and young adults in Denmark

Frederik Nybye Ågesen*, Bjarke Risgaard, Sára Zachariasardóttir, Reza Jabbari, Thomas Hadberg Lynge, Ole Ingemann-Hansen, Gyda Lolk Ottesen, Jørgen Lange Thomsen, Stig Haunsø, Derk Wolfgang Krieger, Bo Gregers Winkel, Jacob Tfelt-Hansen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

Background: Stroke is the fifth leading cause of death in young individuals globally. Data on the burden of sudden death by stroke are sparse in the young. Aims: The aim of this study was to report mortality rates, cause of death, stroke subtype, and symptoms in children and young adults who suffered sudden death by stroke. Methods: We conducted a retrospective, nationwide study including all deaths within Danish borders between 2000–2009 and 2007–2009 in persons aged 1–35 years and 36–49 years, respectively. Two physicians identified all sudden death cases through review of all death certificates. All available autopsy reports and records from hospitals and general practitioners were retrieved and a neurologist identified all sudden death by stroke cases. Results: Of the 14,567 deaths in the 10-year period, there were 1,698 sudden death cases, of which 52 (3%) were sudden death by stroke. There was a male predominance (56%) and the median age was 33 years. The incidence of sudden death by stroke in individuals aged 1–49 years was 0.19 deaths per 100,000 person-years. Stroke was hemorrhagic in 94% of cases, whereof subarachnoid hemorrhage was the cause of death in 63% of cases. Seventeen (33%) cases contacted the healthcare system because of neurological symptoms, whereof one was suspected of having a stroke (6%). Conclusions: Sudden death by stroke in children and young adults occurs primarily due to hemorrhagic stroke. We report a high frequency of neurological symptoms prior to sudden death by stroke. Increased awareness among healthcare professionals towards stroke symptoms in children and young adults may lead to earlier detection of stroke, and thereby potentially lowering the incidence of sudden death by stroke.

OriginalsprogEngelsk
TidsskriftInternational Journal of Stroke
Vol/bind13
Udgave nummer3
Sider (fra-til)285-291
ISSN1747-4930
DOI
StatusUdgivet - apr. 2018

Fingeraftryk

Denmark
Sudden Death
Young Adult
Cause of Death
Delivery of Health Care
Death Certificates
Hospital Records
Incidence
General Practitioners

Citer dette

Ågesen, F. N., Risgaard, B., Zachariasardóttir, S., Jabbari, R., Lynge, T. H., Ingemann-Hansen, O., ... Tfelt-Hansen, J. (2018). Sudden unexpected death caused by stroke: A nationwide study among children and young adults in Denmark. International Journal of Stroke, 13(3), 285-291. https://doi.org/10.1177/1747493017724625
Ågesen, Frederik Nybye ; Risgaard, Bjarke ; Zachariasardóttir, Sára ; Jabbari, Reza ; Lynge, Thomas Hadberg ; Ingemann-Hansen, Ole ; Ottesen, Gyda Lolk ; Thomsen, Jørgen Lange ; Haunsø, Stig ; Krieger, Derk Wolfgang ; Winkel, Bo Gregers ; Tfelt-Hansen, Jacob. / Sudden unexpected death caused by stroke : A nationwide study among children and young adults in Denmark. I: International Journal of Stroke. 2018 ; Bind 13, Nr. 3. s. 285-291.
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abstract = "Background: Stroke is the fifth leading cause of death in young individuals globally. Data on the burden of sudden death by stroke are sparse in the young. Aims: The aim of this study was to report mortality rates, cause of death, stroke subtype, and symptoms in children and young adults who suffered sudden death by stroke. Methods: We conducted a retrospective, nationwide study including all deaths within Danish borders between 2000–2009 and 2007–2009 in persons aged 1–35 years and 36–49 years, respectively. Two physicians identified all sudden death cases through review of all death certificates. All available autopsy reports and records from hospitals and general practitioners were retrieved and a neurologist identified all sudden death by stroke cases. Results: Of the 14,567 deaths in the 10-year period, there were 1,698 sudden death cases, of which 52 (3{\%}) were sudden death by stroke. There was a male predominance (56{\%}) and the median age was 33 years. The incidence of sudden death by stroke in individuals aged 1–49 years was 0.19 deaths per 100,000 person-years. Stroke was hemorrhagic in 94{\%} of cases, whereof subarachnoid hemorrhage was the cause of death in 63{\%} of cases. Seventeen (33{\%}) cases contacted the healthcare system because of neurological symptoms, whereof one was suspected of having a stroke (6{\%}). Conclusions: Sudden death by stroke in children and young adults occurs primarily due to hemorrhagic stroke. We report a high frequency of neurological symptoms prior to sudden death by stroke. Increased awareness among healthcare professionals towards stroke symptoms in children and young adults may lead to earlier detection of stroke, and thereby potentially lowering the incidence of sudden death by stroke.",
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author = "{\AA}gesen, {Frederik Nybye} and Bjarke Risgaard and S{\'a}ra Zachariasard{\'o}ttir and Reza Jabbari and Lynge, {Thomas Hadberg} and Ole Ingemann-Hansen and Ottesen, {Gyda Lolk} and Thomsen, {J{\o}rgen Lange} and Stig Hauns{\o} and Krieger, {Derk Wolfgang} and Winkel, {Bo Gregers} and Jacob Tfelt-Hansen",
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Ågesen, FN, Risgaard, B, Zachariasardóttir, S, Jabbari, R, Lynge, TH, Ingemann-Hansen, O, Ottesen, GL, Thomsen, JL, Haunsø, S, Krieger, DW, Winkel, BG & Tfelt-Hansen, J 2018, 'Sudden unexpected death caused by stroke: A nationwide study among children and young adults in Denmark', International Journal of Stroke, bind 13, nr. 3, s. 285-291. https://doi.org/10.1177/1747493017724625

Sudden unexpected death caused by stroke : A nationwide study among children and young adults in Denmark. / Ågesen, Frederik Nybye; Risgaard, Bjarke; Zachariasardóttir, Sára; Jabbari, Reza; Lynge, Thomas Hadberg; Ingemann-Hansen, Ole; Ottesen, Gyda Lolk; Thomsen, Jørgen Lange; Haunsø, Stig; Krieger, Derk Wolfgang; Winkel, Bo Gregers; Tfelt-Hansen, Jacob.

I: International Journal of Stroke, Bind 13, Nr. 3, 04.2018, s. 285-291.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Sudden unexpected death caused by stroke

T2 - A nationwide study among children and young adults in Denmark

AU - Ågesen, Frederik Nybye

AU - Risgaard, Bjarke

AU - Zachariasardóttir, Sára

AU - Jabbari, Reza

AU - Lynge, Thomas Hadberg

AU - Ingemann-Hansen, Ole

AU - Ottesen, Gyda Lolk

AU - Thomsen, Jørgen Lange

AU - Haunsø, Stig

AU - Krieger, Derk Wolfgang

AU - Winkel, Bo Gregers

AU - Tfelt-Hansen, Jacob

PY - 2018/4

Y1 - 2018/4

N2 - Background: Stroke is the fifth leading cause of death in young individuals globally. Data on the burden of sudden death by stroke are sparse in the young. Aims: The aim of this study was to report mortality rates, cause of death, stroke subtype, and symptoms in children and young adults who suffered sudden death by stroke. Methods: We conducted a retrospective, nationwide study including all deaths within Danish borders between 2000–2009 and 2007–2009 in persons aged 1–35 years and 36–49 years, respectively. Two physicians identified all sudden death cases through review of all death certificates. All available autopsy reports and records from hospitals and general practitioners were retrieved and a neurologist identified all sudden death by stroke cases. Results: Of the 14,567 deaths in the 10-year period, there were 1,698 sudden death cases, of which 52 (3%) were sudden death by stroke. There was a male predominance (56%) and the median age was 33 years. The incidence of sudden death by stroke in individuals aged 1–49 years was 0.19 deaths per 100,000 person-years. Stroke was hemorrhagic in 94% of cases, whereof subarachnoid hemorrhage was the cause of death in 63% of cases. Seventeen (33%) cases contacted the healthcare system because of neurological symptoms, whereof one was suspected of having a stroke (6%). Conclusions: Sudden death by stroke in children and young adults occurs primarily due to hemorrhagic stroke. We report a high frequency of neurological symptoms prior to sudden death by stroke. Increased awareness among healthcare professionals towards stroke symptoms in children and young adults may lead to earlier detection of stroke, and thereby potentially lowering the incidence of sudden death by stroke.

AB - Background: Stroke is the fifth leading cause of death in young individuals globally. Data on the burden of sudden death by stroke are sparse in the young. Aims: The aim of this study was to report mortality rates, cause of death, stroke subtype, and symptoms in children and young adults who suffered sudden death by stroke. Methods: We conducted a retrospective, nationwide study including all deaths within Danish borders between 2000–2009 and 2007–2009 in persons aged 1–35 years and 36–49 years, respectively. Two physicians identified all sudden death cases through review of all death certificates. All available autopsy reports and records from hospitals and general practitioners were retrieved and a neurologist identified all sudden death by stroke cases. Results: Of the 14,567 deaths in the 10-year period, there were 1,698 sudden death cases, of which 52 (3%) were sudden death by stroke. There was a male predominance (56%) and the median age was 33 years. The incidence of sudden death by stroke in individuals aged 1–49 years was 0.19 deaths per 100,000 person-years. Stroke was hemorrhagic in 94% of cases, whereof subarachnoid hemorrhage was the cause of death in 63% of cases. Seventeen (33%) cases contacted the healthcare system because of neurological symptoms, whereof one was suspected of having a stroke (6%). Conclusions: Sudden death by stroke in children and young adults occurs primarily due to hemorrhagic stroke. We report a high frequency of neurological symptoms prior to sudden death by stroke. Increased awareness among healthcare professionals towards stroke symptoms in children and young adults may lead to earlier detection of stroke, and thereby potentially lowering the incidence of sudden death by stroke.

KW - Autopsy

KW - cause of death

KW - incidence

KW - stroke

KW - sudden death

KW - young adults

KW - Age Factors

KW - Humans

KW - Middle Aged

KW - Child, Preschool

KW - Infant

KW - Male

KW - Incidence

KW - Death, Sudden/epidemiology

KW - Young Adult

KW - Denmark/epidemiology

KW - Adolescent

KW - Survival Analysis

KW - Adult

KW - Female

KW - Stroke/epidemiology

KW - Retrospective Studies

KW - Child

U2 - 10.1177/1747493017724625

DO - 10.1177/1747493017724625

M3 - Journal article

VL - 13

SP - 285

EP - 291

JO - International Journal of Stroke

JF - International Journal of Stroke

SN - 1747-4930

IS - 3

ER -

Ågesen FN, Risgaard B, Zachariasardóttir S, Jabbari R, Lynge TH, Ingemann-Hansen O et al. Sudden unexpected death caused by stroke: A nationwide study among children and young adults in Denmark. International Journal of Stroke. 2018 apr;13(3):285-291. https://doi.org/10.1177/1747493017724625