Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)

Katrien Wijndaele*, Thomas White, Lars Bo Andersen, Anna Bugge, Elin Kolle, Kate Northstone, Niels Wedderkopp, Mathias Ried-Larsen, Susi Kriemler, Angie S Page, Jardena J Puder, John J Reilly, Luis B Sardinha, Esther M F van Sluijs, Stephen J Sharp, Søren Brage, Ulf Ekelund, International Children’s Accelerometry Database (ICAD) Collaborators, L B Andersen (Medlem af forfattergruppering), A J Atkin (Medlem af forfattergruppering)G Cardon, R Davey, Ulf Ekelund, D W Esliger, P Hallal, B H Hansen, K F Janz, S Kriemler, N Møller, K Northstone, A Page, R Pate, J J Puder, J J Reilly, J Salmon, L B Sardinha, L B Sherar, A Timperio, E M F van Sluijs

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

38 Downloads (Pure)

Abstrakt

BACKGROUND: Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children.

METHODS: Cross-sectional data from 14 studies (7 countries) in the International Children's Accelerometry Database (ICAD, 1998-2009) was included. Accelerometry in 19,502 participants aged 3-18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed.

RESULTS: Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (- 0.44 (- 0.62; - 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (- 3.07 (- 4.47; - 1.68) cm), systolic blood pressure (- 1.53 (- 2.42; - 0.65) mmHg) and clustered cardio-metabolic risk (- 0.18 (- 0.3; - 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: - 0.81 (- 1.38; - 0.24) mmHg).

CONCLUSIONS: Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.

OriginalsprogEngelsk
Artikelnummer96
TidsskriftInternational Journal of Behavioral Nutrition and Physical Activity
Vol/bind16
Udgave nummer1
Antal sider10
ISSN1479-5868
DOI
StatusUdgivet - 31. okt. 2019

Fingeraftryk

Dyk ned i forskningsemnerne om 'Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD)'. Sammen danner de et unikt fingeraftryk.

Citationsformater