Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype

C. Kragelund, S. B. Jensen, C. H. C. Scient, Kim Brøsen, L. A. Torpet, J. Reibel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Objective. This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6*4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations. Study Design. A total of 111 patients with OLP were categorized according to normal, low, or high CYP1A2 activity and CYP2D6*4 genotype. Lifestyle parameters influencing the CYP1A2 activity and symptoms and manifestations of OLP were recorded. Results. Of the 111 patients, 21% had low, 65% normal, and 14% high CYP1A2 activity. The high-CYP1A2-activity group was more exposed to CYP1A2 inducers than the low-CYP1A2-activity group. In the normal-CYP1A2-activity group, more patients had a CYP2D6*4 genotype (58%) (P = .02), and they presented more symptoms (P = .003) and gingival lesions (P = .03). More patients in the low-CYP1A2-activity group and without CYP2D6*4 genotype presented red lesions (P = .04). Conclusions. We suggest CYP2D6*4 genotype as a disease-susceptible genotype and low or high CYP1A2 activity levels as indicators of environmental influence in OLP subgroups.
OriginalsprogEngelsk
TidsskriftOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Vol/bind118
Udgave nummer4
Sider (fra-til)469-474
ISSN2212-4403
DOI
StatusUdgivet - 2014

Bibliografisk note

ISI Document Delivery No.: AQ0VW Times Cited: 0 Cited Reference Count: 35 Kragelund, C. Jensen, S. B. Scient, C. Hansen Cand Broesen, K. Torpet, L. A. Reibel, J. Novo Nordisk Foundation (Apotekerfonden); Danish Medical Research Council; Danish Dental Association (F.U.T./Calcin Fonden); Forskningsfond The authors thank Novo Nordisk Foundation (Apotekerfonden af 1991), the Danish Medical Research Council, the Danish Dental Association (F.U.T./Calcin Fonden), and the Forskningsfond for financial support. 0 ELSEVIER SCIENCE INC NEW YORK OR SURG OR MED OR PA

Emneord

  • CHRONIC HEPATITIS-C AUTOIMMUNE HEPATITIS CLINICAL-FEATURES DRUG ERUPTIONS LIVER FIBROSIS DISEASE AUTOANTIBODIES POLYMORPHISM ASSOCIATION PROGRESSION

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