Objective. This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6*4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations. Study Design. A total of 111 patients with OLP were categorized according to normal, low, or high CYP1A2 activity and CYP2D6*4 genotype. Lifestyle parameters influencing the CYP1A2 activity and symptoms and manifestations of OLP were recorded. Results. Of the 111 patients, 21% had low, 65% normal, and 14% high CYP1A2 activity. The high-CYP1A2-activity group was more exposed to CYP1A2 inducers than the low-CYP1A2-activity group. In the normal-CYP1A2-activity group, more patients had a CYP2D6*4 genotype (58%) (P = .02), and they presented more symptoms (P = .003) and gingival lesions (P = .03). More patients in the low-CYP1A2-activity group and without CYP2D6*4 genotype presented red lesions (P = .04). Conclusions. We suggest CYP2D6*4 genotype as a disease-susceptible genotype and low or high CYP1A2 activity levels as indicators of environmental influence in OLP subgroups.
|Tidsskrift||Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology|
|Status||Udgivet - 2014|
Bibliografisk noteISI Document Delivery No.: AQ0VW Times Cited: 0 Cited Reference Count: 35 Kragelund, C. Jensen, S. B. Scient, C. Hansen Cand Broesen, K. Torpet, L. A. Reibel, J. Novo Nordisk Foundation (Apotekerfonden); Danish Medical Research Council; Danish Dental Association (F.U.T./Calcin Fonden); Forskningsfond The authors thank Novo Nordisk Foundation (Apotekerfonden af 1991), the Danish Medical Research Council, the Danish Dental Association (F.U.T./Calcin Fonden), and the Forskningsfond for financial support. 0 ELSEVIER SCIENCE INC NEW YORK OR SURG OR MED OR PA
- CHRONIC HEPATITIS-C AUTOIMMUNE HEPATITIS CLINICAL-FEATURES DRUG ERUPTIONS LIVER FIBROSIS DISEASE AUTOANTIBODIES POLYMORPHISM ASSOCIATION PROGRESSION
Kragelund, C., Jensen, S. B., Scient, C. H. C., Brøsen, K., Torpet, L. A., & Reibel, J. (2014). Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 118(4), 469-474. https://doi.org/10.1016/j.oooo.2014.06.008