Structural insights, biocatalytic characteristics, and application prospects of lignin-modifying enzymes for sustainable biotechnology

Anil Kumar Singh, Hafiz M.N. Iqbal, Nunzio Cardullo, Vera Muccilli, Jesús Fernández-Lucas, Jens Ejbye Schmidt, Teofil Jesionowski, Muhammad Bilal*

*Kontaktforfatter

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Abstract

Lignin modifying enzymes (LMEs) have gained widespread recognition in depolymerization of lignin polymers by oxidative cleavage. LMEs are a robust class of biocatalysts that include lignin peroxidase (LiP), manganese peroxidase (MnP), versatile peroxidase (VP), laccase (LAC), and dye-decolorizing peroxidase (DyP). Members of the LMEs family act on phenolic, non-phenolic substrates and have been widely researched for valorization of lignin, oxidative cleavage of xenobiotics and phenolics. LMEs implementation in the biotechnological and industrial sectors has sparked significant attention, although its potential future applications remain underexploited. To understand the mechanism of LMEs in sustainable pollution mitigation, several studies have been undertaken to assess the feasibility of LMEs in correlating to diverse pollutants for binding and intermolecular interactions at the molecular level. However, further investigation is required to fully comprehend the underlying mechanism. In this review we presented the key structural and functional features of LMEs, including the computational aspects, as well as the advanced applications in biotechnology and industrial research. Furthermore, concluding remarks and a look ahead, the use of LMEs coupled with computational framework, built upon artificial intelligence (AI) and machine learning (ML), has been emphasized as a recent milestone in environmental research.

OriginalsprogEngelsk
Artikelnummer124968
TidsskriftInternational Journal of Biological Macromolecules
Vol/bind242
Udgave nummerPt 3
Antal sider28
ISSN0141-8130
DOI
StatusUdgivet - 1. jul. 2023

Bibliografisk note

Funding Information:
AKS would thank the Council of Scientific & Industrial Research (CSIR), India, Academy of Scientific and Innovative Research (AcSIR)-An Institute of National Importance, and CSIR -Indian Institute of Toxicology Research Lucknow, India. The research leading to these results has received funding from the Norwegian Financial Mechanism 2014–2021 under the Project number 2020/37/K/ST8/03805 .

Funding Information:
AKS would thank the Council of Scientific & Industrial Research (CSIR), India, Academy of Scientific and Innovative Research (AcSIR)-An Institute of National Importance, and CSIR-Indian Institute of Toxicology Research Lucknow, India. The research leading to these results has received funding from the Norwegian Financial Mechanism 2014–2021 under the Project number 2020/37/K/ST8/03805.

Publisher Copyright:
© 2023 The Author(s)

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