Strontium functionalized scaffold for bone tissue engineering

Rahul D Prabha; Bindu P Nair; Nicholas Ditzel; Jorgen Kjems; Prabha D Nair; Moustapha Kassem

doi:10.1016/j.msec.2018.09.054

Strontium functionalized scaffold for bone tissue engineering

Rahul D Prabha, Bindu P Nair, Nicholas Ditzel, Jorgen Kjems, Prabha D Nair, Moustapha Kassem

Division of Tissue Engineering & Regeneration Technologies, Sree Chitra Tirunal Institute
Aarhus Universitet
Department of Orthodontics and Dentofacial Orthopaedics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682041, India

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)-laponite-strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

Originalsprog	Engelsk
Tidsskrift	Materials Science and Engineering C
Vol/bind	94
Sider (fra-til)	509-515
ISSN	0928-4931
DOI	https://doi.org/10.1016/j.msec.2018.09.054
Status	Udgivet - 1. jan. 2019

Bibliografisk note

Dokumenter og links

10.1016/j.msec.2018.09.054

Strontium functionalized scaffold for bone tissue engineeringAccepteret manuskript, 12,8 MBLicens: CC BY-NC-ND

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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title = "Strontium functionalized scaffold for bone tissue engineering",

abstract = "Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)-laponite-strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.",

keywords = "Bone, Drug delivery, Laponite, Stem cells, Strontium",

author = "Prabha, {Rahul D} and Nair, {Bindu P} and Nicholas Ditzel and Jorgen Kjems and Nair, {Prabha D} and Moustapha Kassem",

note = "Copyright {\textcopyright} 2018. Published by Elsevier B.V.",

year = "2019",

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doi = "10.1016/j.msec.2018.09.054",

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T1 - Strontium functionalized scaffold for bone tissue engineering

AU - Prabha, Rahul D

AU - Nair, Bindu P

AU - Ditzel, Nicholas

AU - Kjems, Jorgen

AU - Nair, Prabha D

AU - Kassem, Moustapha

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)-laponite-strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

AB - Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)-laponite-strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

KW - Bone

KW - Drug delivery

KW - Laponite

KW - Stem cells

KW - Strontium

U2 - 10.1016/j.msec.2018.09.054

DO - 10.1016/j.msec.2018.09.054

M3 - Journal article

C2 - 30423735

SN - 0928-4931

VL - 94

SP - 509

EP - 515

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

ER -

Strontium functionalized scaffold for bone tissue engineering

Abstract

Bibliografisk note

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater