Strontium functionalized scaffold for bone tissue engineering

Rahul D Prabha, Bindu P Nair, Nicholas Ditzel, Jorgen Kjems, Prabha D Nair, Moustapha Kassem

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)-laponite-strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

OriginalsprogEngelsk
TidsskriftMaterials Science and Engineering C: Biomimetic Materials, Sensors and Systems
Vol/bind94
Sider (fra-til)509-515
ISSN0928-4931
DOI
StatusUdgivet - 1. jan. 2019

Fingeraftryk

strontium ranelate
Tissue Engineering
Stromal Cells
Growth
Dentistry
Osteogenesis
Pharmaceutical Preparations
Orthopedics
polycaprolactone
In Vitro Techniques
laponite

Bibliografisk note

Copyright © 2018. Published by Elsevier B.V.

Citer dette

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title = "Strontium functionalized scaffold for bone tissue engineering",
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Strontium functionalized scaffold for bone tissue engineering. / Prabha, Rahul D; Nair, Bindu P; Ditzel, Nicholas; Kjems, Jorgen; Nair, Prabha D; Kassem, Moustapha.

I: Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems, Bind 94, 01.01.2019, s. 509-515.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Strontium functionalized scaffold for bone tissue engineering

AU - Prabha, Rahul D

AU - Nair, Bindu P

AU - Ditzel, Nicholas

AU - Kjems, Jorgen

AU - Nair, Prabha D

AU - Kassem, Moustapha

N1 - Copyright © 2018. Published by Elsevier B.V.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)-laponite-strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

AB - Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)-laponite-strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

KW - Bone

KW - Drug delivery

KW - Laponite

KW - Stem cells

KW - Strontium

U2 - 10.1016/j.msec.2018.09.054

DO - 10.1016/j.msec.2018.09.054

M3 - Journal article

C2 - 30423735

VL - 94

SP - 509

EP - 515

JO - Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems

JF - Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems

SN - 0928-4931

ER -