Treatment with tibolone partially protects 3-D microarchitecture of lumbar Vertebral Bone Tissues and Prevents Ovariectomy-induced Reduction in Mechanical Properties: Ding M, Dalstra M, Weinans H, Ederveen AG, I Hvid

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Abstrakt

Treatment with Tibolone partially Protects 3-D Microarchitecture of Lumbar Vertebral
Bone Tissues and Prevents Ovariectomy-induced Reduction in Mechanical Properties

Tibolone (Org OD14) is a tissue selective steroid with estrogenic effects on the brain, bone and
vagina, without stimulating the breast and endometrium. A previous study has shown that longterm
treatment with tibolone prevents ovariectomy (OVX) induced bone loss in rats. The aim of
this study was to investigate the effects of tibolone on three-dimensional (3-D) microarchitecture
and mechanical properties of rat lumbar vertebra. We hypothesized that tibolone might have
significant effects on 3-D microarchitecture of vertebra, thus to preserve OVX-induced reduction
in mechanical properties.
One hundred and sixty-six female 10-month-old rats were randomly allocated into one of the 13
groups. These groups included a baseline control group at experiment start-up and three groups
(SHAM, OVX and OVX+tibolone) at each termination point – 4, 14, 34, or 54 weeks. The
treated groups received tibolone 2 mg/kg/day, orally. After sacrifice, rat third lumbar vertebrae
were removed and micro-CT scanned. Microarchitectural properties of the cancellous and
cortical bones were quantified and the mechanical properties of the lumbar cancellous and
cortical bones were determined separately.
Our data demonstrated that OVX lead to pronounced reduction in mechanical properties and
bone mass. Treatment with tibolone increased mechanical properties and improved 3-D
microarchitecture of both cancellous and cortical bone as compared to placebo treatment. Longterm
treatment with tibolone for 54 weeks prevented OVX-induced reduction in the mechanical
properties of both cancellous and cortical bone. Tibolone was shown to have relatively stronger
microarchitectural compensation effect on trabecular bone than on cortical bone. Tibolone
treatment did not prevent OVX-induced microarchitectural deterioration over the entire
experimental period; there was only a statistically significant difference in microarchitectural
parameters between OVX and tibolone groups after 34 weeks of tibolone treatment. This
partially improved microarchitecture resulted in full recovery of mechanical properties to normal
level, suggesting increased bone quality after long-term tibolone treatment. We concluded that
long-term tibolone treatment completely preserved bone’s mechanical properties and partially
protects OVX-induced microarchitectural deterioration.
OriginalsprogEngelsk
Publikationsdato2004
Antal sider1
StatusUdgivet - 2004
BegivenhedAnnual meeting of The American Society for Bone and Mineral Research (ASBMR) 2004 - Seattle, Washington, USA
Varighed: 1. okt. 20045. okt. 2004
Konferencens nummer: 26th

Konference

KonferenceAnnual meeting of The American Society for Bone and Mineral Research (ASBMR) 2004
Nummer26th
LandUSA
BySeattle, Washington
Periode01/10/200405/10/2004

Bibliografisk note

Sider: 237

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