Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study

Aukje L Kreuger, Klaus Rostgaard, Rutger A Middelburg, Jean-Louis H Kerkhoffs, Gustav Edgren, Christian Erikstrup, Ole B Pedersen, Kjell Titlestad, Kaspar R Nielsen, Sisse R Ostrowski, Marianne Voldstedlund, Johanna G van der Bom, Henrik Ullum, Henrik Hjalgrim

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Concern of transfusion-transmitted bacterial infections has been the major hurdle to extend shelf life of platelet (PLT) concentrates. We aimed to investigate the association between storage time and risk of positive blood cultures at different times after transfusion.

STUDY DESIGN AND METHODS: We performed a nationwide cohort study among PLT transfusion recipients in Denmark between 2010 and 2012, as recorded in the Scandinavian Donations and Transfusions (SCANDAT2) database. Linking with a nationwide database on blood cultures (MiBa), we compared the incidence of a positive blood culture among recipients of PLTs stored 6 to 7 days (old) to those receiving fresh PLTs (1-5 days), using Poisson regression models. We considered cumulative exposures in windows of 1, 3, 5, and 7 days.

RESULTS: A total of 9776 patients received 66,101 PLT transfusions. The incidence rate ratio (IRR) of a positive blood culture the day after transfusion of at least one old PLT concentrate was 0.77 (95% confidence interval [CI], 0.54-1.09) compared to transfusion of fresh PLT concentrates. The incidence rate of a positive blood culture was lower the day after receiving one old compared to one fresh PLT concentrate (IRR, 0.57; 95% CI, 0.37-0.87). Three, 5, or 7 days after transfusion, storage time was not associated with the risk of a positive blood culture.

CONCLUSION: Storage of buffy coat-derived PLT concentrates in PAS-C up to 7 days seems safe regarding the risk of a positive blood culture. If anything, transfusion of a single old PLT concentrate may decrease this risk the following day.

OriginalsprogEngelsk
TidsskriftTransfusion
Vol/bind58
Udgave nummer1
Sider (fra-til)16–24
ISSN0041-1132
DOI
StatusUdgivet - jan. 2018

Fingeraftryk

Cohort Studies
Platelet Transfusion
Incidence
Databases
Confidence Intervals
Denmark
Blood Culture

Citer dette

Kreuger, A. L., Rostgaard, K., Middelburg, R. A., Kerkhoffs, J-L. H., Edgren, G., Erikstrup, C., ... Hjalgrim, H. (2018). Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study. Transfusion, 58(1), 16–24. https://doi.org/10.1111/trf.14401
Kreuger, Aukje L ; Rostgaard, Klaus ; Middelburg, Rutger A ; Kerkhoffs, Jean-Louis H ; Edgren, Gustav ; Erikstrup, Christian ; Pedersen, Ole B ; Titlestad, Kjell ; Nielsen, Kaspar R ; Ostrowski, Sisse R ; Voldstedlund, Marianne ; van der Bom, Johanna G ; Ullum, Henrik ; Hjalgrim, Henrik. / Storage time of platelet concentrates and risk of a positive blood culture : a nationwide cohort study. I: Transfusion. 2018 ; Bind 58, Nr. 1. s. 16–24.
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title = "Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study",
abstract = "BACKGROUND: Concern of transfusion-transmitted bacterial infections has been the major hurdle to extend shelf life of platelet (PLT) concentrates. We aimed to investigate the association between storage time and risk of positive blood cultures at different times after transfusion.STUDY DESIGN AND METHODS: We performed a nationwide cohort study among PLT transfusion recipients in Denmark between 2010 and 2012, as recorded in the Scandinavian Donations and Transfusions (SCANDAT2) database. Linking with a nationwide database on blood cultures (MiBa), we compared the incidence of a positive blood culture among recipients of PLTs stored 6 to 7 days (old) to those receiving fresh PLTs (1-5 days), using Poisson regression models. We considered cumulative exposures in windows of 1, 3, 5, and 7 days.RESULTS: A total of 9776 patients received 66,101 PLT transfusions. The incidence rate ratio (IRR) of a positive blood culture the day after transfusion of at least one old PLT concentrate was 0.77 (95{\%} confidence interval [CI], 0.54-1.09) compared to transfusion of fresh PLT concentrates. The incidence rate of a positive blood culture was lower the day after receiving one old compared to one fresh PLT concentrate (IRR, 0.57; 95{\%} CI, 0.37-0.87). Three, 5, or 7 days after transfusion, storage time was not associated with the risk of a positive blood culture.CONCLUSION: Storage of buffy coat-derived PLT concentrates in PAS-C up to 7 days seems safe regarding the risk of a positive blood culture. If anything, transfusion of a single old PLT concentrate may decrease this risk the following day.",
keywords = "Adolescent, Adult, Aged, 80 and over, Bacteremia/epidemiology, Blood Platelets, Blood Preservation/methods, Cohort Studies, Denmark/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Platelet Transfusion/adverse effects, Time Factors, Young Adult",
author = "Kreuger, {Aukje L} and Klaus Rostgaard and Middelburg, {Rutger A} and Kerkhoffs, {Jean-Louis H} and Gustav Edgren and Christian Erikstrup and Pedersen, {Ole B} and Kjell Titlestad and Nielsen, {Kaspar R} and Ostrowski, {Sisse R} and Marianne Voldstedlund and {van der Bom}, {Johanna G} and Henrik Ullum and Henrik Hjalgrim",
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volume = "58",
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Kreuger, AL, Rostgaard, K, Middelburg, RA, Kerkhoffs, J-LH, Edgren, G, Erikstrup, C, Pedersen, OB, Titlestad, K, Nielsen, KR, Ostrowski, SR, Voldstedlund, M, van der Bom, JG, Ullum, H & Hjalgrim, H 2018, 'Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study', Transfusion, bind 58, nr. 1, s. 16–24. https://doi.org/10.1111/trf.14401

Storage time of platelet concentrates and risk of a positive blood culture : a nationwide cohort study. / Kreuger, Aukje L; Rostgaard, Klaus; Middelburg, Rutger A; Kerkhoffs, Jean-Louis H; Edgren, Gustav; Erikstrup, Christian; Pedersen, Ole B; Titlestad, Kjell; Nielsen, Kaspar R; Ostrowski, Sisse R; Voldstedlund, Marianne; van der Bom, Johanna G; Ullum, Henrik; Hjalgrim, Henrik.

I: Transfusion, Bind 58, Nr. 1, 01.2018, s. 16–24.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Storage time of platelet concentrates and risk of a positive blood culture

T2 - a nationwide cohort study

AU - Kreuger, Aukje L

AU - Rostgaard, Klaus

AU - Middelburg, Rutger A

AU - Kerkhoffs, Jean-Louis H

AU - Edgren, Gustav

AU - Erikstrup, Christian

AU - Pedersen, Ole B

AU - Titlestad, Kjell

AU - Nielsen, Kaspar R

AU - Ostrowski, Sisse R

AU - Voldstedlund, Marianne

AU - van der Bom, Johanna G

AU - Ullum, Henrik

AU - Hjalgrim, Henrik

N1 - © 2017 AABB.

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: Concern of transfusion-transmitted bacterial infections has been the major hurdle to extend shelf life of platelet (PLT) concentrates. We aimed to investigate the association between storage time and risk of positive blood cultures at different times after transfusion.STUDY DESIGN AND METHODS: We performed a nationwide cohort study among PLT transfusion recipients in Denmark between 2010 and 2012, as recorded in the Scandinavian Donations and Transfusions (SCANDAT2) database. Linking with a nationwide database on blood cultures (MiBa), we compared the incidence of a positive blood culture among recipients of PLTs stored 6 to 7 days (old) to those receiving fresh PLTs (1-5 days), using Poisson regression models. We considered cumulative exposures in windows of 1, 3, 5, and 7 days.RESULTS: A total of 9776 patients received 66,101 PLT transfusions. The incidence rate ratio (IRR) of a positive blood culture the day after transfusion of at least one old PLT concentrate was 0.77 (95% confidence interval [CI], 0.54-1.09) compared to transfusion of fresh PLT concentrates. The incidence rate of a positive blood culture was lower the day after receiving one old compared to one fresh PLT concentrate (IRR, 0.57; 95% CI, 0.37-0.87). Three, 5, or 7 days after transfusion, storage time was not associated with the risk of a positive blood culture.CONCLUSION: Storage of buffy coat-derived PLT concentrates in PAS-C up to 7 days seems safe regarding the risk of a positive blood culture. If anything, transfusion of a single old PLT concentrate may decrease this risk the following day.

AB - BACKGROUND: Concern of transfusion-transmitted bacterial infections has been the major hurdle to extend shelf life of platelet (PLT) concentrates. We aimed to investigate the association between storage time and risk of positive blood cultures at different times after transfusion.STUDY DESIGN AND METHODS: We performed a nationwide cohort study among PLT transfusion recipients in Denmark between 2010 and 2012, as recorded in the Scandinavian Donations and Transfusions (SCANDAT2) database. Linking with a nationwide database on blood cultures (MiBa), we compared the incidence of a positive blood culture among recipients of PLTs stored 6 to 7 days (old) to those receiving fresh PLTs (1-5 days), using Poisson regression models. We considered cumulative exposures in windows of 1, 3, 5, and 7 days.RESULTS: A total of 9776 patients received 66,101 PLT transfusions. The incidence rate ratio (IRR) of a positive blood culture the day after transfusion of at least one old PLT concentrate was 0.77 (95% confidence interval [CI], 0.54-1.09) compared to transfusion of fresh PLT concentrates. The incidence rate of a positive blood culture was lower the day after receiving one old compared to one fresh PLT concentrate (IRR, 0.57; 95% CI, 0.37-0.87). Three, 5, or 7 days after transfusion, storage time was not associated with the risk of a positive blood culture.CONCLUSION: Storage of buffy coat-derived PLT concentrates in PAS-C up to 7 days seems safe regarding the risk of a positive blood culture. If anything, transfusion of a single old PLT concentrate may decrease this risk the following day.

KW - Adolescent

KW - Adult

KW - Aged, 80 and over

KW - Bacteremia/epidemiology

KW - Blood Platelets

KW - Blood Preservation/methods

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Platelet Transfusion/adverse effects

KW - Time Factors

KW - Young Adult

U2 - 10.1111/trf.14401

DO - 10.1111/trf.14401

M3 - Journal article

C2 - 29168187

VL - 58

SP - 16

EP - 24

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 1

ER -

Kreuger AL, Rostgaard K, Middelburg RA, Kerkhoffs J-LH, Edgren G, Erikstrup C et al. Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study. Transfusion. 2018 jan;58(1):16–24. https://doi.org/10.1111/trf.14401