Status og perspektiver for behandling af de kroniske myeloproliferative neoplasier

Lukas Frans Ocias, Morten Orebo Holmström, Caroline Hasselbalch Riley, Christen Lykkegaard Andersen, Dorthe Rønnov-Jessen, Jørn Starklint, Mikael Frederiksen, Morten Saabye Steffensen, Ole Weis Bjerrum, Sarah Farmer, Hans Torben Mourits-Andersen, Hans Carl Hasselbalch, Thomas Stauffer Larsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Polycythaemia vera, essential thrombocytosis and primary myelofibrosis are closely related, clonal myeloproliferative neoplasms. Our knowledge of the underlying molecular mechanisms driving these diseases has increased dramatically during the latest ten years. Traditionally, treatment of these malignancies has focused on lowering their inherent thromboembolic risk but with the discovery of the JAK2-V617F mutation and most recently the calreticulin mutations new therapeutic options such as interferon-alpha, JAK2-inhibitors and statins are being contemplated. This article reviews these new treatment options.

Bidragets oversatte titelStatus and perspectives on chronic myeloproliferative neoplasm treatment
OriginalsprogDansk
ArtikelnummerV12140652
TidsskriftUgeskrift for Laeger
Vol/bind177
Udgave nummer26
Sider (fra-til)2-6
ISSN0041-5782
StatusUdgivet - 2015

Emneord

  • Algorithms
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
  • Interferon-alpha/therapeutic use
  • Janus Kinase 2/antagonists & inhibitors
  • Myeloproliferative Disorders/drug therapy
  • Polycythemia Vera/drug therapy
  • Primary Myelofibrosis/drug therapy
  • Thrombocytosis/drug therapy

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