Statistical analysis of DNT detection using chemically functionalized microcantilever arrays

F. G. Bosco, M. Bache, E. T. Hwu, C. H. Chen, S. S. Andersen, K. A. Nielsen, S. S. Keller, J. O. Jeppesen, I. S. Hwang, A. Boisen

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Resumé

The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTIT-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior. (C) 2012 Elsevier B.V. All rights reserved.
OriginalsprogEngelsk
TidsskriftSensors and Actuators B: Chemical
Vol/bind171
Sider (fra-til)1054-1059
Antal sider6
ISSN0925-4005
DOI
StatusUdgivet - 2012

Citer dette

Bosco, F. G., Bache, M., Hwu, E. T., Chen, C. H., Andersen, S. S., Nielsen, K. A., ... Boisen, A. (2012). Statistical analysis of DNT detection using chemically functionalized microcantilever arrays. Sensors and Actuators B: Chemical, 171, 1054-1059. https://doi.org/10.1016/j.snb.2012.06.033
Bosco, F. G. ; Bache, M. ; Hwu, E. T. ; Chen, C. H. ; Andersen, S. S. ; Nielsen, K. A. ; Keller, S. S. ; Jeppesen, J. O. ; Hwang, I. S. ; Boisen, A. / Statistical analysis of DNT detection using chemically functionalized microcantilever arrays. I: Sensors and Actuators B: Chemical. 2012 ; Bind 171. s. 1054-1059.
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abstract = "The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTIT-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior. (C) 2012 Elsevier B.V. All rights reserved.",
author = "Bosco, {F. G.} and M. Bache and Hwu, {E. T.} and Chen, {C. H.} and Andersen, {S. S.} and Nielsen, {K. A.} and Keller, {S. S.} and Jeppesen, {J. O.} and Hwang, {I. S.} and A. Boisen",
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Bosco, FG, Bache, M, Hwu, ET, Chen, CH, Andersen, SS, Nielsen, KA, Keller, SS, Jeppesen, JO, Hwang, IS & Boisen, A 2012, 'Statistical analysis of DNT detection using chemically functionalized microcantilever arrays', Sensors and Actuators B: Chemical, bind 171, s. 1054-1059. https://doi.org/10.1016/j.snb.2012.06.033

Statistical analysis of DNT detection using chemically functionalized microcantilever arrays. / Bosco, F. G.; Bache, M.; Hwu, E. T.; Chen, C. H.; Andersen, S. S.; Nielsen, K. A.; Keller, S. S.; Jeppesen, J. O.; Hwang, I. S.; Boisen, A.

I: Sensors and Actuators B: Chemical, Bind 171, 2012, s. 1054-1059.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Statistical analysis of DNT detection using chemically functionalized microcantilever arrays

AU - Bosco, F. G.

AU - Bache, M.

AU - Hwu, E. T.

AU - Chen, C. H.

AU - Andersen, S. S.

AU - Nielsen, K. A.

AU - Keller, S. S.

AU - Jeppesen, J. O.

AU - Hwang, I. S.

AU - Boisen, A.

PY - 2012

Y1 - 2012

N2 - The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTIT-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior. (C) 2012 Elsevier B.V. All rights reserved.

AB - The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTIT-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior. (C) 2012 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.snb.2012.06.033

DO - 10.1016/j.snb.2012.06.033

M3 - Journal article

VL - 171

SP - 1054

EP - 1059

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

SN - 0925-4005

ER -