Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults

W. H. Lo-Ciganic, S. Perera, S. L. Gray, R. M. Boudreau, J. C. Zgibor, E. S. Strotmeyer, J. M. Donohue, C. H. Bunker, A. B. Newman, E. M. Simonsick, D. C. Bauer, S. Satterfield, P. Caserotti, T. Harris, R. I. Shorr, J. T. Hanlon

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

ObjectivesTo examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DesignLongitudinal cohort study. SettingHealth, Aging and Body Composition (Health ABC) Study. ParticipantsTwo thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MeasurementsThe independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. ResultsStatin use increased from 16.2% in 1998-99 to 25.6% in 2002-03. The overall proportions of those with decline in gait speed of 0.1m/s or more increased from 22.2% in 1998 to 23.9% in 2003. Statin use was not associated with decline in gait speed of 0.1m/s or more (adjusted odds ratio (AOR)=0.90, 95% confidence interval (CI)=0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22% lower risk of decline in gait speed than nonusers (AOR=0.78, 95% CI=0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. ConclusionThese results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.
OriginalsprogEngelsk
TidsskriftJournal of the American Geriatrics Society
Vol/bind63
Udgave nummer1
Sider (fra-til)124-129
ISSN0002-8614
DOI
StatusUdgivet - 2015

Bibliografisk note

National Institute on Aging [R01-AG 027017, P30-AG024827, T32-AG021885, K07-AG033174, R01-AG034056, R01-AG028050, N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106]; National Institute of Nursing Research grants [R01-NR010135, R01-NR012459]; Agency for Healthcare Research and Quality grants [R01-HS017695, R01-HS018721]; Intramural Research Program of the National Institutes of Health, National Institute on Aging 0 25537649

Emneord

  • hydroxymethylglutaryl-CoA reductase inhibitors statins gait speed physical function aged PERIPHERAL ARTERIAL-DISEASE COA REDUCTASE INHIBITORS PHYSICAL PERFORMANCE HEALTH ATORVASTATIN CHOLESTEROL PREDICTOR SYMPTOMS THERAPY PEOPLE

Citer dette

Lo-Ciganic, W. H., Perera, S., Gray, S. L., Boudreau, R. M., Zgibor, J. C., Strotmeyer, E. S., ... Hanlon, J. T. (2015). Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults. Journal of the American Geriatrics Society, 63(1), 124-129. https://doi.org/10.1111/jgs.13134
Lo-Ciganic, W. H. ; Perera, S. ; Gray, S. L. ; Boudreau, R. M. ; Zgibor, J. C. ; Strotmeyer, E. S. ; Donohue, J. M. ; Bunker, C. H. ; Newman, A. B. ; Simonsick, E. M. ; Bauer, D. C. ; Satterfield, S. ; Caserotti, P. ; Harris, T. ; Shorr, R. I. ; Hanlon, J. T. / Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults. I: Journal of the American Geriatrics Society. 2015 ; Bind 63, Nr. 1. s. 124-129.
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title = "Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults",
abstract = "ObjectivesTo examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DesignLongitudinal cohort study. SettingHealth, Aging and Body Composition (Health ABC) Study. ParticipantsTwo thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MeasurementsThe independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. ResultsStatin use increased from 16.2{\%} in 1998-99 to 25.6{\%} in 2002-03. The overall proportions of those with decline in gait speed of 0.1m/s or more increased from 22.2{\%} in 1998 to 23.9{\%} in 2003. Statin use was not associated with decline in gait speed of 0.1m/s or more (adjusted odds ratio (AOR)=0.90, 95{\%} confidence interval (CI)=0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22{\%} lower risk of decline in gait speed than nonusers (AOR=0.78, 95{\%} CI=0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. ConclusionThese results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.",
keywords = "hydroxymethylglutaryl-CoA reductase inhibitors statins gait speed physical function aged PERIPHERAL ARTERIAL-DISEASE COA REDUCTASE INHIBITORS PHYSICAL PERFORMANCE HEALTH ATORVASTATIN CHOLESTEROL PREDICTOR SYMPTOMS THERAPY PEOPLE",
author = "Lo-Ciganic, {W. H.} and S. Perera and Gray, {S. L.} and Boudreau, {R. M.} and Zgibor, {J. C.} and Strotmeyer, {E. S.} and Donohue, {J. M.} and Bunker, {C. H.} and Newman, {A. B.} and Simonsick, {E. M.} and Bauer, {D. C.} and S. Satterfield and P. Caserotti and T. Harris and Shorr, {R. I.} and Hanlon, {J. T.}",
note = "National Institute on Aging [R01-AG 027017, P30-AG024827, T32-AG021885, K07-AG033174, R01-AG034056, R01-AG028050, N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106]; National Institute of Nursing Research grants [R01-NR010135, R01-NR012459]; Agency for Healthcare Research and Quality grants [R01-HS017695, R01-HS018721]; Intramural Research Program of the National Institutes of Health, National Institute on Aging 0 25537649",
year = "2015",
doi = "10.1111/jgs.13134",
language = "English",
volume = "63",
pages = "124--129",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
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number = "1",

}

Lo-Ciganic, WH, Perera, S, Gray, SL, Boudreau, RM, Zgibor, JC, Strotmeyer, ES, Donohue, JM, Bunker, CH, Newman, AB, Simonsick, EM, Bauer, DC, Satterfield, S, Caserotti, P, Harris, T, Shorr, RI & Hanlon, JT 2015, 'Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults', Journal of the American Geriatrics Society, bind 63, nr. 1, s. 124-129. https://doi.org/10.1111/jgs.13134

Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults. / Lo-Ciganic, W. H.; Perera, S.; Gray, S. L.; Boudreau, R. M.; Zgibor, J. C.; Strotmeyer, E. S.; Donohue, J. M.; Bunker, C. H.; Newman, A. B.; Simonsick, E. M.; Bauer, D. C.; Satterfield, S.; Caserotti, P.; Harris, T.; Shorr, R. I.; Hanlon, J. T.

I: Journal of the American Geriatrics Society, Bind 63, Nr. 1, 2015, s. 124-129.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults

AU - Lo-Ciganic, W. H.

AU - Perera, S.

AU - Gray, S. L.

AU - Boudreau, R. M.

AU - Zgibor, J. C.

AU - Strotmeyer, E. S.

AU - Donohue, J. M.

AU - Bunker, C. H.

AU - Newman, A. B.

AU - Simonsick, E. M.

AU - Bauer, D. C.

AU - Satterfield, S.

AU - Caserotti, P.

AU - Harris, T.

AU - Shorr, R. I.

AU - Hanlon, J. T.

N1 - National Institute on Aging [R01-AG 027017, P30-AG024827, T32-AG021885, K07-AG033174, R01-AG034056, R01-AG028050, N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106]; National Institute of Nursing Research grants [R01-NR010135, R01-NR012459]; Agency for Healthcare Research and Quality grants [R01-HS017695, R01-HS018721]; Intramural Research Program of the National Institutes of Health, National Institute on Aging 0 25537649

PY - 2015

Y1 - 2015

N2 - ObjectivesTo examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DesignLongitudinal cohort study. SettingHealth, Aging and Body Composition (Health ABC) Study. ParticipantsTwo thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MeasurementsThe independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. ResultsStatin use increased from 16.2% in 1998-99 to 25.6% in 2002-03. The overall proportions of those with decline in gait speed of 0.1m/s or more increased from 22.2% in 1998 to 23.9% in 2003. Statin use was not associated with decline in gait speed of 0.1m/s or more (adjusted odds ratio (AOR)=0.90, 95% confidence interval (CI)=0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22% lower risk of decline in gait speed than nonusers (AOR=0.78, 95% CI=0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. ConclusionThese results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.

AB - ObjectivesTo examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults. DesignLongitudinal cohort study. SettingHealth, Aging and Body Composition (Health ABC) Study. ParticipantsTwo thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MeasurementsThe independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care. ResultsStatin use increased from 16.2% in 1998-99 to 25.6% in 2002-03. The overall proportions of those with decline in gait speed of 0.1m/s or more increased from 22.2% in 1998 to 23.9% in 2003. Statin use was not associated with decline in gait speed of 0.1m/s or more (adjusted odds ratio (AOR)=0.90, 95% confidence interval (CI)=0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22% lower risk of decline in gait speed than nonusers (AOR=0.78, 95% CI=0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up. ConclusionThese results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.

KW - hydroxymethylglutaryl-CoA reductase inhibitors statins gait speed physical function aged PERIPHERAL ARTERIAL-DISEASE COA REDUCTASE INHIBITORS PHYSICAL PERFORMANCE HEALTH ATORVASTATIN CHOLESTEROL PREDICTOR SYMPTOMS THERAPY PEOPLE

U2 - 10.1111/jgs.13134

DO - 10.1111/jgs.13134

M3 - Journal article

C2 - 25537649

VL - 63

SP - 124

EP - 129

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 1

ER -

Lo-Ciganic WH, Perera S, Gray SL, Boudreau RM, Zgibor JC, Strotmeyer ES et al. Statin Use and Decline in Gait Speed in Community-Dwelling Older Adults. Journal of the American Geriatrics Society. 2015;63(1):124-129. https://doi.org/10.1111/jgs.13134