Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles

Filippo Caschera, Jorge Bernardino de la Serna, Philipp M. G. Löffler, Thomas Elmelund Rasmussen, Martin Hanczyc, Luis Bagatolli, Pierre-Alain Monnard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The self-assembly of cationic and anionic amphiphile mixtures into vesicles in aqueous media was studied using two different systems: i) decanoic acid and trimethyldecylammonium bromide ii) hexadecanedioic acid (a simple bola-amphiphile) and trimethyldecylammonium bromide. The resulting vesicles with varying amphiphile ratios were characterized using parameters, such as critical vesicle concentration, pH sensitivity and encapsulation efficiency. We also produced and observed giant vesicles from these mixtures using the electroformation method and confocal microscopy. The mixed catanionic vesicles were shown to be more stable than those formed by pure fatty acids. Those containing bola-amphiphile even showed encapsulation of a small hydrophilic solute (8-hydroxypyrene-1,3,6-trisulfonic-acid) suggesting a denser packing of the amphiphiles. Compression and kinetics analysis of monolayers composed of these amphiphiles mixtures at the air/water interface suggest that the stabilization of the structures can be attributed to two main interactions between headgroups, predominantly the formation of hydrogen bonds between protonated and deprotonated acids and then the additional electrostatic interactions between ammonium and acid headgroups.
OriginalsprogEngelsk
TidsskriftLangmuir
Vol/bind27
Udgave nummer23
Sider (fra-til)14078-14090
ISSN0743-7463
StatusUdgivet - 2011

Fingeraftryk

Amphiphiles
dicarboxylic acids
fatty acids
Fatty acids
Fatty Acids
acids
Acids
bromides
Bromides
Encapsulation
Confocal microscopy
self assembly
Coulomb interactions
Ammonium Compounds
solutes
Self assembly
stabilization
interactions
Monolayers
electrostatics

Citer dette

Caschera, F., Bernardino de la Serna, J., Löffler, P. M. G., Rasmussen, T. E., Hanczyc, M., Bagatolli, L., & Monnard, P-A. (2011). Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles. Langmuir, 27(23), 14078-14090.
Caschera, Filippo ; Bernardino de la Serna, Jorge ; Löffler, Philipp M. G. ; Rasmussen, Thomas Elmelund ; Hanczyc, Martin ; Bagatolli, Luis ; Monnard, Pierre-Alain. / Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles. I: Langmuir. 2011 ; Bind 27, Nr. 23. s. 14078-14090.
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title = "Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles",
abstract = "The self-assembly of cationic and anionic amphiphile mixtures into vesicles in aqueous media was studied using two different systems: i) decanoic acid and trimethyldecylammonium bromide ii) hexadecanedioic acid (a simple bola-amphiphile) and trimethyldecylammonium bromide. The resulting vesicles with varying amphiphile ratios were characterized using parameters, such as critical vesicle concentration, pH sensitivity and encapsulation efficiency. We also produced and observed giant vesicles from these mixtures using the electroformation method and confocal microscopy. The mixed catanionic vesicles were shown to be more stable than those formed by pure fatty acids. Those containing bola-amphiphile even showed encapsulation of a small hydrophilic solute (8-hydroxypyrene-1,3,6-trisulfonic-acid) suggesting a denser packing of the amphiphiles. Compression and kinetics analysis of monolayers composed of these amphiphiles mixtures at the air/water interface suggest that the stabilization of the structures can be attributed to two main interactions between headgroups, predominantly the formation of hydrogen bonds between protonated and deprotonated acids and then the additional electrostatic interactions between ammonium and acid headgroups.",
author = "Filippo Caschera and {Bernardino de la Serna}, Jorge and L{\"o}ffler, {Philipp M. G.} and Rasmussen, {Thomas Elmelund} and Martin Hanczyc and Luis Bagatolli and Pierre-Alain Monnard",
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Caschera, F, Bernardino de la Serna, J, Löffler, PMG, Rasmussen, TE, Hanczyc, M, Bagatolli, L & Monnard, P-A 2011, 'Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles', Langmuir, bind 27, nr. 23, s. 14078-14090.

Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles. / Caschera, Filippo; Bernardino de la Serna, Jorge; Löffler, Philipp M. G.; Rasmussen, Thomas Elmelund; Hanczyc, Martin; Bagatolli, Luis; Monnard, Pierre-Alain.

I: Langmuir, Bind 27, Nr. 23, 2011, s. 14078-14090.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles

AU - Caschera, Filippo

AU - Bernardino de la Serna, Jorge

AU - Löffler, Philipp M. G.

AU - Rasmussen, Thomas Elmelund

AU - Hanczyc, Martin

AU - Bagatolli, Luis

AU - Monnard, Pierre-Alain

PY - 2011

Y1 - 2011

N2 - The self-assembly of cationic and anionic amphiphile mixtures into vesicles in aqueous media was studied using two different systems: i) decanoic acid and trimethyldecylammonium bromide ii) hexadecanedioic acid (a simple bola-amphiphile) and trimethyldecylammonium bromide. The resulting vesicles with varying amphiphile ratios were characterized using parameters, such as critical vesicle concentration, pH sensitivity and encapsulation efficiency. We also produced and observed giant vesicles from these mixtures using the electroformation method and confocal microscopy. The mixed catanionic vesicles were shown to be more stable than those formed by pure fatty acids. Those containing bola-amphiphile even showed encapsulation of a small hydrophilic solute (8-hydroxypyrene-1,3,6-trisulfonic-acid) suggesting a denser packing of the amphiphiles. Compression and kinetics analysis of monolayers composed of these amphiphiles mixtures at the air/water interface suggest that the stabilization of the structures can be attributed to two main interactions between headgroups, predominantly the formation of hydrogen bonds between protonated and deprotonated acids and then the additional electrostatic interactions between ammonium and acid headgroups.

AB - The self-assembly of cationic and anionic amphiphile mixtures into vesicles in aqueous media was studied using two different systems: i) decanoic acid and trimethyldecylammonium bromide ii) hexadecanedioic acid (a simple bola-amphiphile) and trimethyldecylammonium bromide. The resulting vesicles with varying amphiphile ratios were characterized using parameters, such as critical vesicle concentration, pH sensitivity and encapsulation efficiency. We also produced and observed giant vesicles from these mixtures using the electroformation method and confocal microscopy. The mixed catanionic vesicles were shown to be more stable than those formed by pure fatty acids. Those containing bola-amphiphile even showed encapsulation of a small hydrophilic solute (8-hydroxypyrene-1,3,6-trisulfonic-acid) suggesting a denser packing of the amphiphiles. Compression and kinetics analysis of monolayers composed of these amphiphiles mixtures at the air/water interface suggest that the stabilization of the structures can be attributed to two main interactions between headgroups, predominantly the formation of hydrogen bonds between protonated and deprotonated acids and then the additional electrostatic interactions between ammonium and acid headgroups.

M3 - Journal article

VL - 27

SP - 14078

EP - 14090

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 23

ER -

Caschera F, Bernardino de la Serna J, Löffler PMG, Rasmussen TE, Hanczyc M, Bagatolli L et al. Stable Vesicles Composed of Mono- or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles. Langmuir. 2011;27(23):14078-14090.