Squamous Cell Carcinoma of the Nasal Vestibule

J D Horsmans, C Godballe, K E Jørgensen, L Bastholt, E Løntoft

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

From 1978 to 1992, 66 patients (32 women and 34 men) were treated for carcinoma of the nasal vestibule at Odense University Hospital. The treatment was radiotherapy (41 patients), surgery (13 patients) or a combination of the two modalities (12 patients). Twenty-one patients (32%) developed recurrence. Of these, 17 (81%) were diagnosed within the first two years of follow up. The recurrence rate was found to be correlated to the anatomic site of the tumour-origin; septal site of origin meant higher risk of recurrence. Five-year disease specific and crude survival of all patients were 87.0% and 58.5%, respectively. Several variables (sex, age, anatomic site of origin, Wang-classification, tumour volume and regional lymphnode metastases at time of diagnosis) were evaluated as possible prognostic indicators. In univariate analysis, regional lymph node metastases at the time of diagnosis and anatomic site of origin of the tumour showed a significant influence on survival. In multivariate analysis, septal origin of primary tumour was a significant, independent predictive factor of recurrence and the presence of lymph node metastases at the time of diagnosis showed to be a highly significant prognosticator of both disease specific and crude survival (p < 0.0001). We conclude that patients with primary lymph node metastases and septal location of primary tumour need intensive primary treatment and close follow up.

OriginalsprogEngelsk
TidsskriftRhinology
Vol/bind37
Udgave nummer3
Sider (fra-til)117-121
Antal sider5
ISSN0300-0729
StatusUdgivet - 1999

Fingeraftryk

Nose
Lymph Nodes
Neoplasms
Tumor Burden
Multivariate Analysis

Citer dette

Horsmans, J. D., Godballe, C., Jørgensen, K. E., Bastholt, L., & Løntoft, E. (1999). Squamous Cell Carcinoma of the Nasal Vestibule. Rhinology, 37(3), 117-121.
Horsmans, J D ; Godballe, C ; Jørgensen, K E ; Bastholt, L ; Løntoft, E. / Squamous Cell Carcinoma of the Nasal Vestibule. I: Rhinology. 1999 ; Bind 37, Nr. 3. s. 117-121.
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abstract = "From 1978 to 1992, 66 patients (32 women and 34 men) were treated for carcinoma of the nasal vestibule at Odense University Hospital. The treatment was radiotherapy (41 patients), surgery (13 patients) or a combination of the two modalities (12 patients). Twenty-one patients (32{\%}) developed recurrence. Of these, 17 (81{\%}) were diagnosed within the first two years of follow up. The recurrence rate was found to be correlated to the anatomic site of the tumour-origin; septal site of origin meant higher risk of recurrence. Five-year disease specific and crude survival of all patients were 87.0{\%} and 58.5{\%}, respectively. Several variables (sex, age, anatomic site of origin, Wang-classification, tumour volume and regional lymphnode metastases at time of diagnosis) were evaluated as possible prognostic indicators. In univariate analysis, regional lymph node metastases at the time of diagnosis and anatomic site of origin of the tumour showed a significant influence on survival. In multivariate analysis, septal origin of primary tumour was a significant, independent predictive factor of recurrence and the presence of lymph node metastases at the time of diagnosis showed to be a highly significant prognosticator of both disease specific and crude survival (p < 0.0001). We conclude that patients with primary lymph node metastases and septal location of primary tumour need intensive primary treatment and close follow up.",
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Horsmans, JD, Godballe, C, Jørgensen, KE, Bastholt, L & Løntoft, E 1999, 'Squamous Cell Carcinoma of the Nasal Vestibule', Rhinology, bind 37, nr. 3, s. 117-121.

Squamous Cell Carcinoma of the Nasal Vestibule. / Horsmans, J D; Godballe, C; Jørgensen, K E; Bastholt, L; Løntoft, E.

I: Rhinology, Bind 37, Nr. 3, 1999, s. 117-121.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Squamous Cell Carcinoma of the Nasal Vestibule

AU - Horsmans, J D

AU - Godballe, C

AU - Jørgensen, K E

AU - Bastholt, L

AU - Løntoft, E

PY - 1999

Y1 - 1999

N2 - From 1978 to 1992, 66 patients (32 women and 34 men) were treated for carcinoma of the nasal vestibule at Odense University Hospital. The treatment was radiotherapy (41 patients), surgery (13 patients) or a combination of the two modalities (12 patients). Twenty-one patients (32%) developed recurrence. Of these, 17 (81%) were diagnosed within the first two years of follow up. The recurrence rate was found to be correlated to the anatomic site of the tumour-origin; septal site of origin meant higher risk of recurrence. Five-year disease specific and crude survival of all patients were 87.0% and 58.5%, respectively. Several variables (sex, age, anatomic site of origin, Wang-classification, tumour volume and regional lymphnode metastases at time of diagnosis) were evaluated as possible prognostic indicators. In univariate analysis, regional lymph node metastases at the time of diagnosis and anatomic site of origin of the tumour showed a significant influence on survival. In multivariate analysis, septal origin of primary tumour was a significant, independent predictive factor of recurrence and the presence of lymph node metastases at the time of diagnosis showed to be a highly significant prognosticator of both disease specific and crude survival (p < 0.0001). We conclude that patients with primary lymph node metastases and septal location of primary tumour need intensive primary treatment and close follow up.

AB - From 1978 to 1992, 66 patients (32 women and 34 men) were treated for carcinoma of the nasal vestibule at Odense University Hospital. The treatment was radiotherapy (41 patients), surgery (13 patients) or a combination of the two modalities (12 patients). Twenty-one patients (32%) developed recurrence. Of these, 17 (81%) were diagnosed within the first two years of follow up. The recurrence rate was found to be correlated to the anatomic site of the tumour-origin; septal site of origin meant higher risk of recurrence. Five-year disease specific and crude survival of all patients were 87.0% and 58.5%, respectively. Several variables (sex, age, anatomic site of origin, Wang-classification, tumour volume and regional lymphnode metastases at time of diagnosis) were evaluated as possible prognostic indicators. In univariate analysis, regional lymph node metastases at the time of diagnosis and anatomic site of origin of the tumour showed a significant influence on survival. In multivariate analysis, septal origin of primary tumour was a significant, independent predictive factor of recurrence and the presence of lymph node metastases at the time of diagnosis showed to be a highly significant prognosticator of both disease specific and crude survival (p < 0.0001). We conclude that patients with primary lymph node metastases and septal location of primary tumour need intensive primary treatment and close follow up.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Analysis of Variance

KW - Carcinoma, Squamous Cell

KW - Combined Modality Therapy

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Nasal Cavity

KW - Nose Neoplasms

KW - Prognosis

KW - Proportional Hazards Models

KW - Survival Analysis

KW - Survival Rate

KW - Treatment Outcome

M3 - Journal article

VL - 37

SP - 117

EP - 121

JO - Rhinology

JF - Rhinology

SN - 0300-0729

IS - 3

ER -

Horsmans JD, Godballe C, Jørgensen KE, Bastholt L, Løntoft E. Squamous Cell Carcinoma of the Nasal Vestibule. Rhinology. 1999;37(3):117-121.