Splice switching oligonucleotides pseudoexons

Brage Andresen (Opfinder), Thomas Doktor (Opfinder), Lise Holm (Opfinder), Ulrika Simone Spangsberg Petersen (Opfinder), Gitte Bruun (Opfinder)

Publikation: Patent

Abstract

The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.

OriginalsprogEngelsk
IPCA61K31/7088, C12N15/11,C12N15/113
PatentnummerAU2022213196 (A1)
Land/OmrådeDanmark
Prioritetsdato26/01/2021
PrioritetsnummerWO2022EP51790
StatusUdgivet - 10. aug. 2023

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