Splice switching oligonucleotides pseudoexons

Brage Andresen; Thomas Doktor; Lise Holm; Ulrika Simone Spangsberg Petersen; Gitte Bruun

Splice switching oligonucleotides pseudoexons

Brage Andresen (Opfinder), Thomas Doktor (Opfinder), Lise Holm (Opfinder), Ulrika Simone Spangsberg Petersen (Opfinder), Gitte Bruun (Opfinder)

Publikation: Patent

Abstract

The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.

Originalsprog	Engelsk
IPC	A61K31/7088, C12N15/11,C12N15/113
Patentnummer	AU2022213196 (A1)
Land/Område	Danmark
Prioritetsdato	26/01/2021
Prioritetsnummer	WO2022EP51790
Status	Udgivet - 10. aug. 2023

SDU link

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Citationsformater

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title = "Splice switching oligonucleotides pseudoexons",

abstract = "The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.",

author = "Brage Andresen and Thomas Doktor and Lise Holm and Petersen, \{Ulrika Simone Spangsberg\} and Gitte Bruun",

year = "2023",

month = aug,

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type = "Patent",

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TY - PAT

T1 - Splice switching oligonucleotides pseudoexons

AU - Andresen, Brage

AU - Doktor, Thomas

AU - Holm, Lise

AU - Petersen, Ulrika Simone Spangsberg

AU - Bruun, Gitte

PY - 2023/8/10

Y1 - 2023/8/10

N2 - The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.

AB - The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.

M3 - Patent

M1 - AU2022213196 (A1)

ER -

Splice switching oligonucleotides pseudoexons

Abstract

SDU link

Fingeraftryk

Citationsformater