Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin

Mette Høj Lauridsen, Trine Welløv Boesgaard, Oluf Borbye Pedersen, Torben Hansen, Birgitte Hertz

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months. PNDM-patients should be screened for gene mutations regardless of current age.
Udgivelsesdato: 2009-Jun-1
OriginalsprogDansk
TidsskriftUgeskrift for læger
Vol/bind171
Udgave nummer23
Sider (fra-til)1923-4
Antal sider1
ISSN0041-5782
StatusUdgivet - 1. jun. 2009

Citer dette

Lauridsen, M. H., Boesgaard, T. W., Pedersen, O. B., Hansen, T., & Hertz, B. (2009). Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin. Ugeskrift for læger, 171(23), 1923-4.
Lauridsen, Mette Høj ; Boesgaard, Trine Welløv ; Pedersen, Oluf Borbye ; Hansen, Torben ; Hertz, Birgitte. / Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin. I: Ugeskrift for læger. 2009 ; Bind 171, Nr. 23. s. 1923-4.
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abstract = "A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months. PNDM-patients should be screened for gene mutations regardless of current age. Udgivelsesdato: 2009-Jun-1",
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Lauridsen, MH, Boesgaard, TW, Pedersen, OB, Hansen, T & Hertz, B 2009, 'Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin', Ugeskrift for læger, bind 171, nr. 23, s. 1923-4.

Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin. / Lauridsen, Mette Høj; Boesgaard, Trine Welløv; Pedersen, Oluf Borbye; Hansen, Torben; Hertz, Birgitte.

I: Ugeskrift for læger, Bind 171, Nr. 23, 01.06.2009, s. 1923-4.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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T1 - Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin

AU - Lauridsen, Mette Høj

AU - Boesgaard, Trine Welløv

AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

AU - Hertz, Birgitte

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N2 - A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months. PNDM-patients should be screened for gene mutations regardless of current age. Udgivelsesdato: 2009-Jun-1

AB - A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months. PNDM-patients should be screened for gene mutations regardless of current age. Udgivelsesdato: 2009-Jun-1

KW - Child, Preschool

KW - Diabetes Mellitus, Type 1

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KW - Female

KW - Glyburide

KW - Humans

KW - Hypoglycemic Agents

KW - Infant

KW - Insulin

KW - Mutation

KW - Potassium Channels, Inwardly Rectifying

KW - Treatment Outcome

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Lauridsen MH, Boesgaard TW, Pedersen OB, Hansen T, Hertz B. Spædbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin. Ugeskrift for læger. 2009 jun 1;171(23):1923-4.