Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome

Dominik J Schaer, Boris Schleiffenbaum, Michael Kurrer, Alexander Imhof, Esther Bächli, Jörg Fehr, Holger J Moller, Soren K Moestrup, Andreas Schaffner

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum levels of the macrophage specific scavenger receptor CD163 were determined by enzyme-linked immunosorbent assay (ELISA) and were found to be highly increased in patients with RHS (median 39.0 mg/L). Significantly lower levels were determined in patients with sepsis (median 9.1 mg/L), acute mononucleosis (median 8.2 mg/L), Leishmania infection (median 6.7 mg/L) and healthy controls (median 1.8 mg/L). Follow-up of patients with a relapsing course of the disease revealed close correlations of sCD163 with clinical disease activity, serum ferritin and other markers of macrophage activity. Large sinusoidal accumulations of CD163 expressing macrophages actively engaged in phagocytosis of blood cells were detected in spleen sections of RHS patients. Our data suggests sCD163 to be a macrophage-specific marker in patients with disorders of inappropriate macrophage activation.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Haematology
Vol/bind74
Udgave nummer1
Sider (fra-til)6-10
Antal sider5
ISSN0902-4441
DOI
StatusUdgivet - jan. 2005

Fingeraftryk

Hemophagocytic Lymphohistiocytosis
Scavenger Receptors
Macrophages
Macrophage Activation
Serum
Neoplasms

Citer dette

Schaer, Dominik J ; Schleiffenbaum, Boris ; Kurrer, Michael ; Imhof, Alexander ; Bächli, Esther ; Fehr, Jörg ; Moller, Holger J ; Moestrup, Soren K ; Schaffner, Andreas. / Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. I: European Journal of Haematology. 2005 ; Bind 74, Nr. 1. s. 6-10.
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abstract = "Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum levels of the macrophage specific scavenger receptor CD163 were determined by enzyme-linked immunosorbent assay (ELISA) and were found to be highly increased in patients with RHS (median 39.0 mg/L). Significantly lower levels were determined in patients with sepsis (median 9.1 mg/L), acute mononucleosis (median 8.2 mg/L), Leishmania infection (median 6.7 mg/L) and healthy controls (median 1.8 mg/L). Follow-up of patients with a relapsing course of the disease revealed close correlations of sCD163 with clinical disease activity, serum ferritin and other markers of macrophage activity. Large sinusoidal accumulations of CD163 expressing macrophages actively engaged in phagocytosis of blood cells were detected in spleen sections of RHS patients. Our data suggests sCD163 to be a macrophage-specific marker in patients with disorders of inappropriate macrophage activation.",
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Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. / Schaer, Dominik J; Schleiffenbaum, Boris; Kurrer, Michael; Imhof, Alexander; Bächli, Esther; Fehr, Jörg; Moller, Holger J; Moestrup, Soren K; Schaffner, Andreas.

I: European Journal of Haematology, Bind 74, Nr. 1, 01.2005, s. 6-10.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome

AU - Schaer, Dominik J

AU - Schleiffenbaum, Boris

AU - Kurrer, Michael

AU - Imhof, Alexander

AU - Bächli, Esther

AU - Fehr, Jörg

AU - Moller, Holger J

AU - Moestrup, Soren K

AU - Schaffner, Andreas

PY - 2005/1

Y1 - 2005/1

N2 - Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum levels of the macrophage specific scavenger receptor CD163 were determined by enzyme-linked immunosorbent assay (ELISA) and were found to be highly increased in patients with RHS (median 39.0 mg/L). Significantly lower levels were determined in patients with sepsis (median 9.1 mg/L), acute mononucleosis (median 8.2 mg/L), Leishmania infection (median 6.7 mg/L) and healthy controls (median 1.8 mg/L). Follow-up of patients with a relapsing course of the disease revealed close correlations of sCD163 with clinical disease activity, serum ferritin and other markers of macrophage activity. Large sinusoidal accumulations of CD163 expressing macrophages actively engaged in phagocytosis of blood cells were detected in spleen sections of RHS patients. Our data suggests sCD163 to be a macrophage-specific marker in patients with disorders of inappropriate macrophage activation.

AB - Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte/macrophage activation lack lineage-restricted expression patterns and thus specificity. Serum levels of the macrophage specific scavenger receptor CD163 were determined by enzyme-linked immunosorbent assay (ELISA) and were found to be highly increased in patients with RHS (median 39.0 mg/L). Significantly lower levels were determined in patients with sepsis (median 9.1 mg/L), acute mononucleosis (median 8.2 mg/L), Leishmania infection (median 6.7 mg/L) and healthy controls (median 1.8 mg/L). Follow-up of patients with a relapsing course of the disease revealed close correlations of sCD163 with clinical disease activity, serum ferritin and other markers of macrophage activity. Large sinusoidal accumulations of CD163 expressing macrophages actively engaged in phagocytosis of blood cells were detected in spleen sections of RHS patients. Our data suggests sCD163 to be a macrophage-specific marker in patients with disorders of inappropriate macrophage activation.

KW - Adolescent

KW - Adult

KW - Antigens, CD

KW - Antigens, Differentiation, Myelomonocytic

KW - Biological Markers

KW - Case-Control Studies

KW - Enzyme-Linked Immunosorbent Assay

KW - Histiocytosis, Non-Langerhans-Cell

KW - Humans

KW - Infectious Mononucleosis

KW - Leishmaniasis

KW - Macrophage Activation

KW - Receptors, Cell Surface

KW - Sepsis

KW - Solubility

U2 - 10.1111/j.1600-0609.2004.00318.x

DO - 10.1111/j.1600-0609.2004.00318.x

M3 - Journal article

VL - 74

SP - 6

EP - 10

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 1

ER -