Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives

P Jest, K E Pedersen, N A Klitgaard, J Rokkedal Nielsen, A Arentoft, Torben Johansen

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Resumé

Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.
OriginalsprogEngelsk
TidsskriftActa medica Scandinavica. Supplementum
Vol/bind714
Sider (fra-til)75-9
Antal sider5
ISSN0365-463X
StatusUdgivet - 1986

Fingeraftryk

Homeostasis
Salts
Sodium-Potassium-Exchanging ATPase

Citer dette

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abstract = "Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.",
keywords = "Adult, Blood Pressure, Diet, Sodium-Restricted, Homeostasis, Humans, Hypertension, Lymphocytes, Male, Middle Aged, Potassium, Sodium",
author = "P Jest and Pedersen, {K E} and Klitgaard, {N A} and {Rokkedal Nielsen}, J and A Arentoft and Torben Johansen",
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Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives. / Jest, P; Pedersen, K E; Klitgaard, N A; Rokkedal Nielsen, J; Arentoft, A; Johansen, Torben.

I: Acta medica Scandinavica. Supplementum, Bind 714, 1986, s. 75-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives

AU - Jest, P

AU - Pedersen, K E

AU - Klitgaard, N A

AU - Rokkedal Nielsen, J

AU - Arentoft, A

AU - Johansen, Torben

PY - 1986

Y1 - 1986

N2 - Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.

AB - Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.

KW - Adult

KW - Blood Pressure

KW - Diet, Sodium-Restricted

KW - Homeostasis

KW - Humans

KW - Hypertension

KW - Lymphocytes

KW - Male

KW - Middle Aged

KW - Potassium

KW - Sodium

M3 - Journal article

VL - 714

SP - 75

EP - 79

JO - Acta medica Scandinavica. Supplementum

JF - Acta medica Scandinavica. Supplementum

SN - 0365-463X

ER -