Snus and risk of gastroesophageal reflux. A population-based case-control study: the HUNT study

Tina Malene Lie, Maria Bomme, Kristian Hveem, Jane Møller Hansen, Eivind Ness-Jensen

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Resumé

OBJECTIVE: Tobacco smoking is a risk factor for gastroesophageal reflux, but whether other tobacco products increase the risk is unclear. The aim of this study was to investigate if snus increases the risk of gastroesophageal reflux symptoms (GERS).

MATERIAL AND METHODS: The study was based on the third Nord-Trøndelag health study (HUNT3), a population-based study of all adult residents in Nord-Trøndelag County, Norway, performed in 2006-2009. The association between self-reported severe heartburn/regurgitation and snus use was assessed by logistic regression.

RESULTS: Compared to never snus users, daily snus users had a reduced risk of GERS (OR 0.77, 95% confidence interval [CI] 0.64-0.93), while previous snus users and those using <2 boxes of snus/month had an increased risk (OR 1.20, 95% CI 1.00-1.46 and OR 1.41, 95% CI 1.02-1.96, respectively). There was no association between age when starting using snus and GERS. Snus users who started using snus to quit or cut down on cigarette smoking, who started using both snus and cigarettes or cigarettes alone had an increased risk of GERS. Snus users <30 years of age had an increased risk of GERS (OR 1.49, 95% CI 1.02-2.16), while those aged between 50-60 and 60-70 years had a reduced risk (OR 0.67, 95% CI 0.49-0.93 and OR 0.51, 95% CI 0.28-0.94, respectively).

CONCLUSIONS: Daily snus users had a reduced risk of GERS. However, previous snus users and subgroups of snus users had an increased risk of GERS indicating reverse causality, such that snus use could increase the risk of GERS.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Gastroenterology
Vol/bind52
Udgave nummer2
Sider (fra-til)193-198
ISSN0036-5521
DOI
StatusUdgivet - 2017

Fingeraftryk

Gastroesophageal Reflux
Case-Control Studies
Population
Confidence Intervals
Smoking
Heartburn
Norway
Causality
Logistic Models
Health

Citer dette

Lie, Tina Malene ; Bomme, Maria ; Hveem, Kristian ; Hansen, Jane Møller ; Ness-Jensen, Eivind. / Snus and risk of gastroesophageal reflux. A population-based case-control study : the HUNT study. I: Scandinavian Journal of Gastroenterology. 2017 ; Bind 52, Nr. 2. s. 193-198.
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title = "Snus and risk of gastroesophageal reflux. A population-based case-control study: the HUNT study",
abstract = "OBJECTIVE: Tobacco smoking is a risk factor for gastroesophageal reflux, but whether other tobacco products increase the risk is unclear. The aim of this study was to investigate if snus increases the risk of gastroesophageal reflux symptoms (GERS).MATERIAL AND METHODS: The study was based on the third Nord-Tr{\o}ndelag health study (HUNT3), a population-based study of all adult residents in Nord-Tr{\o}ndelag County, Norway, performed in 2006-2009. The association between self-reported severe heartburn/regurgitation and snus use was assessed by logistic regression.RESULTS: Compared to never snus users, daily snus users had a reduced risk of GERS (OR 0.77, 95{\%} confidence interval [CI] 0.64-0.93), while previous snus users and those using <2 boxes of snus/month had an increased risk (OR 1.20, 95{\%} CI 1.00-1.46 and OR 1.41, 95{\%} CI 1.02-1.96, respectively). There was no association between age when starting using snus and GERS. Snus users who started using snus to quit or cut down on cigarette smoking, who started using both snus and cigarettes or cigarettes alone had an increased risk of GERS. Snus users <30 years of age had an increased risk of GERS (OR 1.49, 95{\%} CI 1.02-2.16), while those aged between 50-60 and 60-70 years had a reduced risk (OR 0.67, 95{\%} CI 0.49-0.93 and OR 0.51, 95{\%} CI 0.28-0.94, respectively).CONCLUSIONS: Daily snus users had a reduced risk of GERS. However, previous snus users and subgroups of snus users had an increased risk of GERS indicating reverse causality, such that snus use could increase the risk of GERS.",
author = "Lie, {Tina Malene} and Maria Bomme and Kristian Hveem and Hansen, {Jane M{\o}ller} and Eivind Ness-Jensen",
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Snus and risk of gastroesophageal reflux. A population-based case-control study : the HUNT study. / Lie, Tina Malene; Bomme, Maria; Hveem, Kristian; Hansen, Jane Møller; Ness-Jensen, Eivind.

I: Scandinavian Journal of Gastroenterology, Bind 52, Nr. 2, 2017, s. 193-198.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Snus and risk of gastroesophageal reflux. A population-based case-control study

T2 - the HUNT study

AU - Lie, Tina Malene

AU - Bomme, Maria

AU - Hveem, Kristian

AU - Hansen, Jane Møller

AU - Ness-Jensen, Eivind

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: Tobacco smoking is a risk factor for gastroesophageal reflux, but whether other tobacco products increase the risk is unclear. The aim of this study was to investigate if snus increases the risk of gastroesophageal reflux symptoms (GERS).MATERIAL AND METHODS: The study was based on the third Nord-Trøndelag health study (HUNT3), a population-based study of all adult residents in Nord-Trøndelag County, Norway, performed in 2006-2009. The association between self-reported severe heartburn/regurgitation and snus use was assessed by logistic regression.RESULTS: Compared to never snus users, daily snus users had a reduced risk of GERS (OR 0.77, 95% confidence interval [CI] 0.64-0.93), while previous snus users and those using <2 boxes of snus/month had an increased risk (OR 1.20, 95% CI 1.00-1.46 and OR 1.41, 95% CI 1.02-1.96, respectively). There was no association between age when starting using snus and GERS. Snus users who started using snus to quit or cut down on cigarette smoking, who started using both snus and cigarettes or cigarettes alone had an increased risk of GERS. Snus users <30 years of age had an increased risk of GERS (OR 1.49, 95% CI 1.02-2.16), while those aged between 50-60 and 60-70 years had a reduced risk (OR 0.67, 95% CI 0.49-0.93 and OR 0.51, 95% CI 0.28-0.94, respectively).CONCLUSIONS: Daily snus users had a reduced risk of GERS. However, previous snus users and subgroups of snus users had an increased risk of GERS indicating reverse causality, such that snus use could increase the risk of GERS.

AB - OBJECTIVE: Tobacco smoking is a risk factor for gastroesophageal reflux, but whether other tobacco products increase the risk is unclear. The aim of this study was to investigate if snus increases the risk of gastroesophageal reflux symptoms (GERS).MATERIAL AND METHODS: The study was based on the third Nord-Trøndelag health study (HUNT3), a population-based study of all adult residents in Nord-Trøndelag County, Norway, performed in 2006-2009. The association between self-reported severe heartburn/regurgitation and snus use was assessed by logistic regression.RESULTS: Compared to never snus users, daily snus users had a reduced risk of GERS (OR 0.77, 95% confidence interval [CI] 0.64-0.93), while previous snus users and those using <2 boxes of snus/month had an increased risk (OR 1.20, 95% CI 1.00-1.46 and OR 1.41, 95% CI 1.02-1.96, respectively). There was no association between age when starting using snus and GERS. Snus users who started using snus to quit or cut down on cigarette smoking, who started using both snus and cigarettes or cigarettes alone had an increased risk of GERS. Snus users <30 years of age had an increased risk of GERS (OR 1.49, 95% CI 1.02-2.16), while those aged between 50-60 and 60-70 years had a reduced risk (OR 0.67, 95% CI 0.49-0.93 and OR 0.51, 95% CI 0.28-0.94, respectively).CONCLUSIONS: Daily snus users had a reduced risk of GERS. However, previous snus users and subgroups of snus users had an increased risk of GERS indicating reverse causality, such that snus use could increase the risk of GERS.

U2 - 10.1080/00365521.2016.1245775

DO - 10.1080/00365521.2016.1245775

M3 - Journal article

C2 - 27797289

VL - 52

SP - 193

EP - 198

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 2

ER -