Smooth muscle cells in atherosclerosis originate from the local vessel wall and not circulating progenitor cells in ApoE knockout mice

Jacob Fog Bentzon, Charlotte Weile, Claus S Sondergaard, Johnny Hindkjaer, Moustapha Kassem, Erling Falk

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Abstrakt

Recent studies of bone marrow (BM)-transplanted apoE knockout (apoE-/-) mice have concluded that a substantial fraction of smooth muscle cells (SMCs) in atherosclerosis arise from circulating progenitor cells of hematopoietic origin. This pathway, however, remains controversial. In the present study, we reexamined the origin of plaque SMCs in apoE-/- mice by a series of BM transplantations and in a novel model of atherosclerosis induced in surgically transferred arterial segments.
OriginalsprogEngelsk
TidsskriftArteriosclerosis, Thrombosis, and Vascular Biology
Vol/bind26
Udgave nummer12
Sider (fra-til)2696-2702
ISSN1079-5642
DOI
StatusUdgivet - 2006

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