S‐mephenytoin, sparteine and debrisoquine oxidation: genetic polymorphisms in a Turkish population.

NE Basci*, K. Brosen, A. Bozkurt, A. Isimer, A. Sayal, SO Kayaalp

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Abstrakt

A mephenytoin test was carried out in 106 unrelated healthy Turkish volunteers. Racemic mephenytoin was coadministered with either debrisoquine or sparteine. The S/R mephenytoin ratio ranged from < 0.1 to 0.73 in 105 subjects, accordingly phenotyped as extensive metabolisers. One subject had an S/R mephenytoin ratio of 1.02, showing that he was a poor metaboliser of mephenytoin (0.94%, confidence interval 0.25% and 13.65%). In 48 subjects, the metabolic ratios of debrisoquine and sparteine were correlated significantly (rs = 0.61, P < 0.001). 1994 The British Pharmacological Society

OriginalsprogEngelsk
TidsskriftBritish Journal of Clinical Pharmacology
Vol/bind38
Udgave nummer5
Sider (fra-til)463-465
Antal sider3
ISSN0306-5251
DOI
StatusUdgivet - 1. jan. 1994

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