Six Different Fat Tolerance Tests in Young, Healthy Subjects: Gender Dependent Postprandial Lipemia and Glucose

Ole Winther Rasmussen, Finn Friis Lauszus

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Background: exacerbated postprandial lipid responses are associated with an increaseed cardiovascular risk. Meals with different types of fat may effect postprandial responses differently. the aim og is tudy bwas to evaluate the postprandial lipemia in young healthy subjects after six oral fat tolerenctes (OFTT) with varying amoun of saturated fat. Methods: With six different types of fatin random order to tomatoes we measured postprandial lipemia, lipoprotein, glucose and insulin increments for eight hours in 14 young lean healthy students, seven of each gender. The area under the curve (AUC) was dtermined for the postprandial values. Results: The meals with six types of butters had similar postprandial response even if the saturated fat content varied with 50%.Gender significantly affected the TG responses, as time to pesk was 90 minutes in women and 180 min in men. Postprandial AUC was higherwith respect to TG (p<0.001), LDL-cholesterol (p<0.002), total cholesterol (p<0.027) nd glucose (pa0.009) in men compared to women . HDL cholesterol was lowest in men (AUC, p<0.001).No association with gender was found with free fatty acids and insulin AUCs. Conclusions: The six OFTT gave similar metabolic responses and postprandial lipemia was gender-specific. Replacement of saturated fat by mono- or polyunsaturated fat did not alter postprandial lipemia during single OFTT
TidsskriftPrensa Medica Argentina
Udgave nummer5
Sider (fra-til)102-110
StatusUdgivet - 28. okt. 2016