Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology.

Motoko Sasaki, Koichi Tsuneyama, Takahito Saito, Hiroaki Kataoka, Jan Mollenhauer, Annemarie Poustka, Yasuni Nakanuma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2004-Feb
OriginalsprogEngelsk
TidsskriftLiver International
Vol/bind24
Udgave nummer1
Sider (fra-til)29-37
Antal sider8
ISSN1478-3223
DOI
StatusUdgivet - 1. feb. 2004

Fingeraftryk

Biliary Liver Cirrhosis
Sclerosing Cholangitis
Chronic Hepatitis
Trefoil Factor-3
Trefoil Factor-1
Liver
Liver Diseases
Homeostasis
Epithelium

Citer dette

Sasaki, Motoko ; Tsuneyama, Koichi ; Saito, Takahito ; Kataoka, Hiroaki ; Mollenhauer, Jan ; Poustka, Annemarie ; Nakanuma, Yasuni. / Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. I: Liver International. 2004 ; Bind 24, Nr. 1. s. 29-37.
@article{f596ee2057fb11ddb1a1000ea68e967b,
title = "Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology.",
abstract = "BACKGROUND/AIM: Trefoil factor family (TFF)1,2,3 are involved in a homeostasis/repair process of mucosal epithelia. In this study, the significance of TFF family and deleted in the malignant brain tumor-1 (DMBT1), a putative receptor of TFF2, in the intrahepatic biliary tree was investigated in normal and diseased livers. MATERIALS AND METHODS: Expression of TFF1,2,3 and DMBT1 were examined immunohistochemically in primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), chronic viral hepatitis (CVH), extrahepatic biliary obstruction (EBO), and normal livers. RESULTS: In normal livers, TFF1,3 and DMBT1 were infrequently detectable in large and rarely in small bile ducts, respectively. TFF2 was not detectable in large bile ducts. In large bile duct diseases (PSC and EBO), expression of TFF3 and DMBT1 were increased. In small bile duct diseases (PBC and CVH), expression of TFF2/DMBT1 was induced in moderately to severely damaged ducts irrespective of etiology. CONCLUSION: The intrahepatic biliary tree shows a site-characteristic expression and induction of TFF1,2,3 and DMBT1. In large bile ducts, TFF1,3 were constitutively expressed and increased in pathologic bile ducts. In small bile ducts, TFF2/DMBT1 is induced in damaged ducts irrespective of etiologies. However, the cytoprotective/repair property of TFF2/DMBT1 may not be enough to prevent the following bile duct loss in PBC.",
keywords = "Agglutinins, Bile Duct Diseases, Bile Ducts, Intrahepatic, Cholangitis, Sclerosing, Cholestasis, Digestive System Diseases, Hepatitis, Chronic, Hepatitis, Viral, Human, Humans, Liver Cirrhosis, Biliary, Mucins, Muscle Proteins, Neuropeptides, Peptides, Receptors, Cell Surface",
author = "Motoko Sasaki and Koichi Tsuneyama and Takahito Saito and Hiroaki Kataoka and Jan Mollenhauer and Annemarie Poustka and Yasuni Nakanuma",
year = "2004",
month = "2",
day = "1",
doi = "10.1111/j.1478-3231.2004.00883.x",
language = "English",
volume = "24",
pages = "29--37",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "1",

}

Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. / Sasaki, Motoko; Tsuneyama, Koichi; Saito, Takahito; Kataoka, Hiroaki; Mollenhauer, Jan; Poustka, Annemarie; Nakanuma, Yasuni.

I: Liver International, Bind 24, Nr. 1, 01.02.2004, s. 29-37.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology.

AU - Sasaki, Motoko

AU - Tsuneyama, Koichi

AU - Saito, Takahito

AU - Kataoka, Hiroaki

AU - Mollenhauer, Jan

AU - Poustka, Annemarie

AU - Nakanuma, Yasuni

PY - 2004/2/1

Y1 - 2004/2/1

N2 - BACKGROUND/AIM: Trefoil factor family (TFF)1,2,3 are involved in a homeostasis/repair process of mucosal epithelia. In this study, the significance of TFF family and deleted in the malignant brain tumor-1 (DMBT1), a putative receptor of TFF2, in the intrahepatic biliary tree was investigated in normal and diseased livers. MATERIALS AND METHODS: Expression of TFF1,2,3 and DMBT1 were examined immunohistochemically in primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), chronic viral hepatitis (CVH), extrahepatic biliary obstruction (EBO), and normal livers. RESULTS: In normal livers, TFF1,3 and DMBT1 were infrequently detectable in large and rarely in small bile ducts, respectively. TFF2 was not detectable in large bile ducts. In large bile duct diseases (PSC and EBO), expression of TFF3 and DMBT1 were increased. In small bile duct diseases (PBC and CVH), expression of TFF2/DMBT1 was induced in moderately to severely damaged ducts irrespective of etiology. CONCLUSION: The intrahepatic biliary tree shows a site-characteristic expression and induction of TFF1,2,3 and DMBT1. In large bile ducts, TFF1,3 were constitutively expressed and increased in pathologic bile ducts. In small bile ducts, TFF2/DMBT1 is induced in damaged ducts irrespective of etiologies. However, the cytoprotective/repair property of TFF2/DMBT1 may not be enough to prevent the following bile duct loss in PBC.

AB - BACKGROUND/AIM: Trefoil factor family (TFF)1,2,3 are involved in a homeostasis/repair process of mucosal epithelia. In this study, the significance of TFF family and deleted in the malignant brain tumor-1 (DMBT1), a putative receptor of TFF2, in the intrahepatic biliary tree was investigated in normal and diseased livers. MATERIALS AND METHODS: Expression of TFF1,2,3 and DMBT1 were examined immunohistochemically in primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), chronic viral hepatitis (CVH), extrahepatic biliary obstruction (EBO), and normal livers. RESULTS: In normal livers, TFF1,3 and DMBT1 were infrequently detectable in large and rarely in small bile ducts, respectively. TFF2 was not detectable in large bile ducts. In large bile duct diseases (PSC and EBO), expression of TFF3 and DMBT1 were increased. In small bile duct diseases (PBC and CVH), expression of TFF2/DMBT1 was induced in moderately to severely damaged ducts irrespective of etiology. CONCLUSION: The intrahepatic biliary tree shows a site-characteristic expression and induction of TFF1,2,3 and DMBT1. In large bile ducts, TFF1,3 were constitutively expressed and increased in pathologic bile ducts. In small bile ducts, TFF2/DMBT1 is induced in damaged ducts irrespective of etiologies. However, the cytoprotective/repair property of TFF2/DMBT1 may not be enough to prevent the following bile duct loss in PBC.

KW - Agglutinins

KW - Bile Duct Diseases

KW - Bile Ducts, Intrahepatic

KW - Cholangitis, Sclerosing

KW - Cholestasis

KW - Digestive System Diseases

KW - Hepatitis, Chronic

KW - Hepatitis, Viral, Human

KW - Humans

KW - Liver Cirrhosis, Biliary

KW - Mucins

KW - Muscle Proteins

KW - Neuropeptides

KW - Peptides

KW - Receptors, Cell Surface

U2 - 10.1111/j.1478-3231.2004.00883.x

DO - 10.1111/j.1478-3231.2004.00883.x

M3 - Journal article

C2 - 15101998

VL - 24

SP - 29

EP - 37

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 1

ER -