TY - JOUR

T1 - Simple numerical chromosome aberrations in two pituitary adenomas

AU - Dietrich, C U

AU - Pandis, N

AU - Bjerre, P

AU - Schrøder, H D

AU - Heim, S

PY - 1993/9

Y1 - 1993/9

N2 - Cytogenetic analysis of short-term cultures of one non-secreting and one prolactin-producing pituitary adenoma revealed simple clonal numerical abnormalities in both tumors. The karyotype of the non-secreting adenoma was 48,XX, +4, +9[42]/49,XX, +4, +9, +20[2]/46,XX[6]. In the prolactin-secreting adenoma, three aberrant clones were detected, giving the karyotype 45,X, -Y[20]/47,XY, +Y[6]/45,XY, -21[3]/46,XY[21]. One cell had the chromosome complement 46,X, -Y, +9; no other nonclonal aberrations were detected. The only hitherto published case of pituitary adenoma analyzed by banding techniques (Rey et al. [1986]: Cancer Genet Cytogenet 23:171-174) also had only numerical clonal changes that included extra copies of chromosome 9. We conclude that pituitary adenomas may be karyotypically characterized by numerical aberrations and that trisomy 9 seems to be the best candidate for a primary chromosomal anomaly.

AB - Cytogenetic analysis of short-term cultures of one non-secreting and one prolactin-producing pituitary adenoma revealed simple clonal numerical abnormalities in both tumors. The karyotype of the non-secreting adenoma was 48,XX, +4, +9[42]/49,XX, +4, +9, +20[2]/46,XX[6]. In the prolactin-secreting adenoma, three aberrant clones were detected, giving the karyotype 45,X, -Y[20]/47,XY, +Y[6]/45,XY, -21[3]/46,XY[21]. One cell had the chromosome complement 46,X, -Y, +9; no other nonclonal aberrations were detected. The only hitherto published case of pituitary adenoma analyzed by banding techniques (Rey et al. [1986]: Cancer Genet Cytogenet 23:171-174) also had only numerical clonal changes that included extra copies of chromosome 9. We conclude that pituitary adenomas may be karyotypically characterized by numerical aberrations and that trisomy 9 seems to be the best candidate for a primary chromosomal anomaly.

KW - Adenoma

KW - Adult

KW - Aged

KW - Chromosome Aberrations

KW - Chromosome Banding

KW - Chromosomes, Human, Pair 4

KW - Chromosomes, Human, Pair 9

KW - Female

KW - Humans

KW - Karyotyping

KW - Male

KW - Pituitary Neoplasms

KW - Prolactinoma

KW - Trisomy

KW - Y Chromosome

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 8402547

VL - 69

SP - 118

EP - 121

JO - Cancer genetics and cytogenetics

JF - Cancer genetics and cytogenetics

SN - 0165-4608

IS - 2

ER -