Cytogenetic analysis of short-term cultures of one non-secreting and one prolactin-producing pituitary adenoma revealed simple clonal numerical abnormalities in both tumors. The karyotype of the non-secreting adenoma was 48,XX, +4, +9/49,XX, +4, +9, +20/46,XX. In the prolactin-secreting adenoma, three aberrant clones were detected, giving the karyotype 45,X, -Y/47,XY, +Y/45,XY, -21/46,XY. One cell had the chromosome complement 46,X, -Y, +9; no other nonclonal aberrations were detected. The only hitherto published case of pituitary adenoma analyzed by banding techniques (Rey et al. : Cancer Genet Cytogenet 23:171-174) also had only numerical clonal changes that included extra copies of chromosome 9. We conclude that pituitary adenomas may be karyotypically characterized by numerical aberrations and that trisomy 9 seems to be the best candidate for a primary chromosomal anomaly.
|Tidsskrift||Cancer genetics and cytogenetics|
|Status||Udgivet - sep. 1993|