Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial

Johan Ursing; Poul-Erik Kofoed; Amabelia Rodrigues; Daniel Blessborn; Rikke Thoft-Nielsen; Anders Björkman; Lars Rombo

doi:10.1093/infdis/jiq001

Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial

Johan Ursing
, Poul-Erik Kofoed
, Amabelia Rodrigues
, Daniel Blessborn
, Rikke Thoft-Nielsen
, Anders Björkman
, Lars Rombo

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

In 2008, Guinea-Bissau introduced artemether-lumefantrine for treatment of uncomplicated malaria. Previously, 3 times the standard dose of chloroquine, that was probably efficacious against Plasmodium falciparum with the resistance-associated chloroquine-resistance transporter (pfcrt) 76T allele, was routinely used. The present study compared the efficacy and tolerability of a double standard dose of chloroquine with the efficacy and tolerability of artemether-lumefantrine.

Originalsprog	Engelsk
Tidsskrift	The Journal of Infectious Diseases
Vol/bind	203
Udgave nummer	1
Sider (fra-til)	109-16
Antal sider	8
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jiq001
Status	Udgivet - 1. jan. 2011

Dokumenter og links

10.1093/infdis/jiq001

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Ursing, J., Kofoed, P.-E., Rodrigues, A., Blessborn, D., Thoft-Nielsen, R., Björkman, A., & Rombo, L. (2011). Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial. The Journal of Infectious Diseases, 203(1), 109-16. https://doi.org/10.1093/infdis/jiq001

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abstract = "In 2008, Guinea-Bissau introduced artemether-lumefantrine for treatment of uncomplicated malaria. Previously, 3 times the standard dose of chloroquine, that was probably efficacious against Plasmodium falciparum with the resistance-associated chloroquine-resistance transporter (pfcrt) 76T allele, was routinely used. The present study compared the efficacy and tolerability of a double standard dose of chloroquine with the efficacy and tolerability of artemether-lumefantrine.",

keywords = "Adolescent, Amino Acid Substitution, Antimalarials, Artemisinins, Blood Chemical Analysis, Child, Child, Preschool, Chloroquine, Chromatography, High Pressure Liquid, DNA, Protozoan, Drug Combinations, Ethanolamines, Female, Fluorenes, Guinea-Bissau, Humans, Infant, Malaria, Falciparum, Male, Membrane Transport Proteins, Mutation, Missense, Plasmodium falciparum, Point Mutation, Polymerase Chain Reaction, Protozoan Proteins, Treatment Outcome",

author = "Johan Ursing and Poul-Erik Kofoed and Amabelia Rodrigues and Daniel Blessborn and Rikke Thoft-Nielsen and Anders Bj{\"o}rkman and Lars Rombo",

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Ursing, J, Kofoed, P-E, Rodrigues, A, Blessborn, D, Thoft-Nielsen, R, Björkman, A & Rombo, L 2011, 'Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial', The Journal of Infectious Diseases, bind 203, nr. 1, s. 109-16. https://doi.org/10.1093/infdis/jiq001

Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial. / Ursing, Johan; Kofoed, Poul-Erik; Rodrigues, Amabelia et al.
I: The Journal of Infectious Diseases, Bind 203, Nr. 1, 01.01.2011, s. 109-16.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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T1 - Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial

AU - Ursing, Johan

AU - Kofoed, Poul-Erik

AU - Rodrigues, Amabelia

AU - Blessborn, Daniel

AU - Thoft-Nielsen, Rikke

AU - Björkman, Anders

AU - Rombo, Lars

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N2 - In 2008, Guinea-Bissau introduced artemether-lumefantrine for treatment of uncomplicated malaria. Previously, 3 times the standard dose of chloroquine, that was probably efficacious against Plasmodium falciparum with the resistance-associated chloroquine-resistance transporter (pfcrt) 76T allele, was routinely used. The present study compared the efficacy and tolerability of a double standard dose of chloroquine with the efficacy and tolerability of artemether-lumefantrine.

AB - In 2008, Guinea-Bissau introduced artemether-lumefantrine for treatment of uncomplicated malaria. Previously, 3 times the standard dose of chloroquine, that was probably efficacious against Plasmodium falciparum with the resistance-associated chloroquine-resistance transporter (pfcrt) 76T allele, was routinely used. The present study compared the efficacy and tolerability of a double standard dose of chloroquine with the efficacy and tolerability of artemether-lumefantrine.

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KW - Amino Acid Substitution

KW - Antimalarials

KW - Artemisinins

KW - Blood Chemical Analysis

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KW - Child, Preschool

KW - Chloroquine

KW - Chromatography, High Pressure Liquid

KW - DNA, Protozoan

KW - Drug Combinations

KW - Ethanolamines

KW - Female

KW - Fluorenes

KW - Guinea-Bissau

KW - Humans

KW - Infant

KW - Malaria, Falciparum

KW - Male

KW - Membrane Transport Proteins

KW - Mutation, Missense

KW - Plasmodium falciparum

KW - Point Mutation

KW - Polymerase Chain Reaction

KW - Protozoan Proteins

KW - Treatment Outcome

U2 - 10.1093/infdis/jiq001

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ER -

Similar efficacy and tolerability of double-dose chloroquine and artemether-lumefantrine for treatment of Plasmodium falciparum infection in Guinea-Bissau: a randomized trial

Abstract

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater