Significance of atypia in conventional Papanicolaou smears and liquid-based cytology: a follow-up study

D Schledermann, D Ejersbo, B Hoelund

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2004-Jun
OriginalsprogEngelsk
TidsskriftCytopathology
Vol/bind15
Udgave nummer3
Sider (fra-til)148-53
Antal sider5
ISSN0956-5507
DOI
StatusUdgivet - 1. jun. 2004

Fingeraftryk

Cell Biology
Epithelial Cells

Citer dette

@article{86e8b530bd4e11deab49000ea68e967b,
title = "Significance of atypia in conventional Papanicolaou smears and liquid-based cytology: a follow-up study",
abstract = "The diagnosis of atypical squamous epithelial cells, borderline nuclear changes, is associated with some controversy, as it encompasses benign, reactive, as well as possible neoplastic conditions. The aim of this study was to evaluate the follow-up diagnoses of cytological atypia in conventional Papanicolaou smears (CP) and liquid-based samples by the ThinPrep Pap Test (TP). A total of 1607 CP smears from 1 January 2000 to 31 December 2000 and 798 TP samples from 1 January 2002 to 31 December 2002 diagnosed as atypia were included. The results show that the detection rate of atypia in cervical cytological samples was reduced by 41.3{\%} (P < 0.001) in TP compared with CP. Cytological and histological follow-up data showed the presence of neoplastic lesions in 34.7{\%} of patients screened by TP versus 22.3{\%} of patients screened by CP, corresponding to a 55.6{\%} increase in TP (P < 0.001). Follow-up diagnosis of mild dysplasia was seen more than twice as often in TP than in CP (12.8{\%} versus 5.0{\%}, P < 0.001). The prevalence of moderate and severe dysplasia was significantly increased with 26.7{\%} in TP compared with CP (21.9{\%} versus 17.2{\%}, P < 0.01). In conclusion, the ThinPrep Pap Test yielded a significant decrease in atypia rates compared with the conventional Papanicolaou test. In subsequent follow-up the percentage of neoplastic lesions was significantly increased in the ThinPrep Pap Test samples.",
keywords = "Adult, Cytological Techniques, Denmark, Epithelial Cells, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasms, Squamous Cell, Uterine Cervical Neoplasms, Vaginal Smears",
author = "D Schledermann and D Ejersbo and B Hoelund",
year = "2004",
month = "6",
day = "1",
doi = "10.1111/j.1365-2303.2004.00139.x",
language = "English",
volume = "15",
pages = "148--53",
journal = "Cytopathology",
issn = "0956-5507",
publisher = "Wiley-Blackwell",
number = "3",

}

Significance of atypia in conventional Papanicolaou smears and liquid-based cytology: a follow-up study. / Schledermann, D; Ejersbo, D; Hoelund, B.

I: Cytopathology, Bind 15, Nr. 3, 01.06.2004, s. 148-53.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Significance of atypia in conventional Papanicolaou smears and liquid-based cytology: a follow-up study

AU - Schledermann, D

AU - Ejersbo, D

AU - Hoelund, B

PY - 2004/6/1

Y1 - 2004/6/1

N2 - The diagnosis of atypical squamous epithelial cells, borderline nuclear changes, is associated with some controversy, as it encompasses benign, reactive, as well as possible neoplastic conditions. The aim of this study was to evaluate the follow-up diagnoses of cytological atypia in conventional Papanicolaou smears (CP) and liquid-based samples by the ThinPrep Pap Test (TP). A total of 1607 CP smears from 1 January 2000 to 31 December 2000 and 798 TP samples from 1 January 2002 to 31 December 2002 diagnosed as atypia were included. The results show that the detection rate of atypia in cervical cytological samples was reduced by 41.3% (P < 0.001) in TP compared with CP. Cytological and histological follow-up data showed the presence of neoplastic lesions in 34.7% of patients screened by TP versus 22.3% of patients screened by CP, corresponding to a 55.6% increase in TP (P < 0.001). Follow-up diagnosis of mild dysplasia was seen more than twice as often in TP than in CP (12.8% versus 5.0%, P < 0.001). The prevalence of moderate and severe dysplasia was significantly increased with 26.7% in TP compared with CP (21.9% versus 17.2%, P < 0.01). In conclusion, the ThinPrep Pap Test yielded a significant decrease in atypia rates compared with the conventional Papanicolaou test. In subsequent follow-up the percentage of neoplastic lesions was significantly increased in the ThinPrep Pap Test samples.

AB - The diagnosis of atypical squamous epithelial cells, borderline nuclear changes, is associated with some controversy, as it encompasses benign, reactive, as well as possible neoplastic conditions. The aim of this study was to evaluate the follow-up diagnoses of cytological atypia in conventional Papanicolaou smears (CP) and liquid-based samples by the ThinPrep Pap Test (TP). A total of 1607 CP smears from 1 January 2000 to 31 December 2000 and 798 TP samples from 1 January 2002 to 31 December 2002 diagnosed as atypia were included. The results show that the detection rate of atypia in cervical cytological samples was reduced by 41.3% (P < 0.001) in TP compared with CP. Cytological and histological follow-up data showed the presence of neoplastic lesions in 34.7% of patients screened by TP versus 22.3% of patients screened by CP, corresponding to a 55.6% increase in TP (P < 0.001). Follow-up diagnosis of mild dysplasia was seen more than twice as often in TP than in CP (12.8% versus 5.0%, P < 0.001). The prevalence of moderate and severe dysplasia was significantly increased with 26.7% in TP compared with CP (21.9% versus 17.2%, P < 0.01). In conclusion, the ThinPrep Pap Test yielded a significant decrease in atypia rates compared with the conventional Papanicolaou test. In subsequent follow-up the percentage of neoplastic lesions was significantly increased in the ThinPrep Pap Test samples.

KW - Adult

KW - Cytological Techniques

KW - Denmark

KW - Epithelial Cells

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Middle Aged

KW - Neoplasms, Squamous Cell

KW - Uterine Cervical Neoplasms

KW - Vaginal Smears

U2 - 10.1111/j.1365-2303.2004.00139.x

DO - 10.1111/j.1365-2303.2004.00139.x

M3 - Journal article

VL - 15

SP - 148

EP - 153

JO - Cytopathology

JF - Cytopathology

SN - 0956-5507

IS - 3

ER -