Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Clara Amalie Gade Timmermann, Esben Budtz-Jørgensen, Maria Skaalum Petersen, Pál Weihe, Ulrike Steuerwald, Flemming Nielsen, Tina Kold Jensen, Philippe Grandjean

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    Abstrakt

    The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed. In two Faroese birth cohorts (N=1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

    OriginalsprogEngelsk
    TidsskriftReproductive Toxicology
    Vol/bind68
    Sider (fra-til)164-170
    ISSN0890-6238
    DOI
    StatusUdgivet - 2017

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